Conserved Protein Domain Family
PhoA

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COG1785: PhoA 
Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
Alkaline phosphatase is part of the Pathway/BioSystem: Folate biosynthesis
Statistics
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PSSM-Id: 441391
Aligned: 412 rows
Threshold Bit Score: 230.113
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AFZ24373       1 MISFLgkyqrslalA-MAs-LLCplLLvf--------gNPA----------------VQ--PALAAGNGINVIIMIGDGM 52 
WP_011232175   4 SKRRTa----------L---LIA--VLsaglalhq--------------aeqdawaaPA--KQSKPSEVKNVVLFVGDGM 52 
WP_012876236   3 LKSKV---------VyLL--LAI--ALvmsvp--------------------laivrGA--GNRSPVRARSVIFLMGDGM 47 
WP_013370018   6 MKKSI---------LaLS--AVT--VLtvpll-sadipTAFaaatstkstvaeskaqKA--VSAKADTPKNVILFIGDGM 69 
WP_083835729   5 GARRGw----------VAtgGAA--LLaag------laAGGvapgglatgqddvqrgGG--GRGPSGTAKNVVLVVGDGL 64 
WP_044276475   1 -MRRL-----------Li--ILLalALlt-------asFSP-----------------V--YSQTEVQTGNVIFFHPDGS 40 
WP_014742192   9 LQRRT---------LpLC--LAA--TLvgggvvv-----------------llpgaaSA--GGDGRGHPRSVIFVNGDGM 56 
WP_082040101   1 --------------------------Mpaad------------------------qgrV--ATTQGIPTGNVIFMHPDGT 28 
WP_106892078   1 -MRSA-----------L---LCF--ALasa-------------------------vvpT--LAFAKAPAASAMFLHPDGM 36 
WP_105185466  12 LAGRAtg------vLaVA--VAA--LLastvsgasmaqVRVadrpvtltaesvntpeVAgyDINTKGRARNVIFIQGDGM 81 
AFZ24373      53 GWEMARAAAVAKGgpfytagkgSGLSFQTLtgYGQVTTYGTtiqsntpstpnnlakstgnsaldgtnqvtglspvrpgfs 132
WP_011232175  53 GTAHRNAIRLATKgi------aGELEMDDMpySGLVHTNSA--------------------------------------- 87 
WP_012876236  48 GATQRDAIQLVTVgp------yGRLTMDQLpyTGMMSTNSV--------------------------------------- 82 
WP_013370018  70 GEASRNAIRLATVgk------sGLLEMDKMpiTGLVSTSSG--------------------------------------- 104
WP_083835729  65 SIAARDAIRLSTVgk------dGLLAMDQLryAGWTATDSA--------------------------------------- 99 
WP_044276475  41 GLNHWNAARMYWYgp------dGELHWDQLpeMAIYRGHMS--------------------------------------- 75 
WP_014742192  57 AAAHREAARLDQEgf------dGQLAMDSLpiAGLQTTDAR--------------------------------------- 91 
WP_082040101  29 GLSHWAAHRMYFHgl------dGTSNWDLLpqMAVYRGHLE--------------------------------------- 63 
WP_106892078  37 GANTWNVLRMKEVgp------dGRLAWDALpaLAIYVGPVD--------------------------------------- 71 
WP_105185466  82 GVAHRELLRLALKgq------nGDLVMNKMqvTGLVHTDSA--------------------------------------- 116
AFZ24373     133 lqptpfnpgttangdtllpgnlagyDVtkggpapwiplspanpgtydkeyikySYPDSANTATTLYTGVKSYN-NAMGVD 211
WP_011232175  88 -------------------------DSk------------------------sFITDSAAAATAIASGVKTYN-GAISVD 117
WP_012876236  83 -------------------------DPk------------------------tFVTDSAAGATAWAIGRKTYN-GAIAVD 112
WP_013370018 105 -------------------------DN--------------------------LVTDSAAAATAIATGVKTYN-GAIGMD 132
WP_083835729 100 -------------------------DPd------------------------dAVTDSAAAATAFATGVRTYN-GAVAVD 129
WP_044276475  76 -------------------------DR--------------------------LVGTSNGGATVHAFGYKVLGpGSFGKD 104
WP_014742192  92 -------------------------DPe------------------------dTITDSAASASAWATGVKTYN-GAISVD 121
WP_082040101  64 -------------------------NL--------------------------VAGTSHGSATTHAFGFKVDAfGSFGMD 92 
WP_106892078  72 -------------------------DS--------------------------VNASSNAGATTHAYGVRTHL-ESFGLD 99 
WP_105185466 117 -------------------------DTa------------------------qAVTDSAAAATAYATGVRSYN-GAIGVD 146
AFZ24373     212 I--Y----EQ---K-----L-------KTIVEIAKEQGKSTGVVTSVPISHATPGAAVSFVNRRSKYDsdydpnkanqdS 270
WP_011232175 118 L--Q----GK---P-----V-------ETILEQAKKAGKATGLVTTAQVTDATPAAFAAHTANRSAQS-----------D 165
WP_012876236 113 A--Q----GK---P-----W-------PTLLEEAKQAGKSVGLVTTSQVTDASPAAFGAHVEDRDEQS-----------E 160
WP_013370018 133 L--N----KK---P-----V-------TTIMELAKKAGMSTGVVTTSQVTDATGAAFGAHVEKRSAQS-----------E 180
WP_083835729 130 V--D----GN---P-----V-------RTLLEHAKALRKATGLVTTAQVTDATPAAFGAHVPDRGTQT-----------E 177
WP_044276475 105 GgiDpeepGSegrP-----IlslsgypGSIMREAAAAGMPVGIVNDGDLPEPGTGAFLAEVGDRNLSN-----------E 168
WP_014742192 122 V--D----GA---P-----L-------PTIGQEAQQAGLATGIVTTAQVTDASPAAFFSNSVDRSAQD-----------D 169
WP_082040101  93 G--D----GNl-nPptnraInslsgfrGSLMREAANAGIPVGVVNDGHIGEPGTGAFLAEVGNRDNWQ-----------E 154
WP_106892078 100 R--A----GDv--Pknae------gqrLSIARQAMQAGRKLVLINSSSITEPGTAAFLASIKDRDDEA-----------G 154
WP_105185466 147 V--N----GK---P-----V-------TNLLERARAAGKSTGLVTTAQVTDASPGAFSAHVANRSDQS-----------E 194
AFZ24373     271 ILQQALln-------fQPNVILGGGHPLDHQnst-------------------ssGPvcnnTSyTyiKASTYKELTGkta 324
WP_011232175 166 IAKQYIeq-------tKVDVILGGGEDYWYPagnpgyyp--------dhpaedpeEA----SK-Gt-QGNLVERAKQ--- 221
WP_012876236 161 IARQYLes-------sKVDVILGGGEDYWYPkgdpgafp--------dhpkedpeEG----SK-Gn-RGNLVREAKR--- 216
WP_013370018 181 IAKQYLek-------sKLDVILGGGEDFWYPagtpgkhp--------dapaedpeEA----SK-Gt-QGNLVEQAKK--- 236
WP_083835729 178 IARQLVev-------sRPDVILGGGEDWWYPtgdegayp--------ddpadprpEV----SR-St-IGNLVERAQE--- 233
WP_044276475 169 IARQFLdgrpgfegeplPKVLLGGGEGFFLPsdtpacgeeitldcyvhvdqvngrGP----AR-Dd-GRNLLKEAAD--- 239
WP_014742192 170 IARQYLqv-------sQPQVILGGGEDWWLPagdegtyap-------ragdtedpEV----SR-St-QGDLVAQAEG--- 226
WP_082040101 155 ITRQMIlgrtg-mndtAPWVIMGGGEADALPigattvhrnvn--qergaaapnlrLS----LR-Td-NLNLIDAWNG--- 222
WP_106892078 155 IAAQLLa--------aGPDIMLGGGEQFFLPagkq----------------grhgAG----LR-Qd-GRDLVKEAEA--- 201
WP_105185466 195 IARQIIeq-------sRVDVVLGGGEDWWYPagnpgawp--------dnpptdptEQ----SK-Gt-KGNLVDRAKQ--- 250
AFZ24373     325 lsneaacsapassnpnnRyG-------------YTFLERGpnatQTLlntAAsV------NpntGGKLFGLYGargqDGN 385
WP_011232175 222 -----------------L-G-------------YTYVRTA----DEL---KQ-A------S---GRKLLGLFA----NEE 249
WP_012876236 217 -----------------L-G-------------YTYVTDR----QEL---MA-A------R---GPKVLGLFA----NEE 244
WP_013370018 237 -----------------L-G-------------YSYVTDQ----AEM---KA-A------K---GSKLLGLFA----NEE 264
WP_083835729 234 -----------------V-G-------------YTYVSTA----AEL---EA-A------D---ADRLLGLFA----NEE 261
WP_044276475 240 -----------------L-G-------------YVVIRTR----AEF---DA-LweriqaEpdyAPMVLGLFA----RDD 276
WP_014742192 227 -----------------L-G-------------YEYVSTA----AEF---AA-A------D---SDQLLGLFA----NEE 254
WP_082040101 223 -----------------M-GsgnasndpalrddFIVVRTR----AEF---EI-LrqalaaNptyAPRVLGLFA----FQD 272
WP_106892078 202 -----------------A-G-------------YVVVFTR----EEL---AA-Lpr-------dAKKVLGLFA----AEA 231
WP_105185466 251 -----------------L-K-------------YQYVTNA----AEL---GK-V------N---KGKVLGLFA----NEE 278
AFZ24373     386 IPVSSskgdysttglgqftlfssttsanqtpnpDTirpl-spgEt---------------Nasfi-----areINENP-- 442
WP_011232175 250 MFQQR----------------------------PE--------Ge---------------Gd------------VYNPvv 266
WP_012876236 245 MFQQR----------------------------PE--------Ge---------------Ga------------VYSPvv 261
WP_013370018 265 MFQAH----------------------------NKl------------------------Gn------------SYNPtv 280
WP_083835729 262 MFEQA----------------------------PE--------Gq---------------Gd------------EYAPvv 278
WP_044276475 277 IFNDTt---------------------------EErlialglvDdsmkg-------tkegRliiwgs-rpgtpGYNPP-- 319
WP_014742192 255 MFQQR----------------------------PE--------Gq---------------Gd------------EFAPvv 271
WP_082040101 273 TFNDRn---------------------------EQdlinrgfvRagvapgtigpapfkqsRlvlwgdfdpaepGFNPP-- 323
WP_106892078 232 TFNELs---------------------------EAkmr--------------------kqKlt--------pfQPQAP-- 254
WP_105185466 279 MFEYH----------------------------NE--------Ge---------------Gd------------LYDPsv 295
AFZ24373     443 TLADMTQAALTVLGK--------DP----DGFWLMVEGGDVDWAAHDDNMDNLIGTMNDFDKAVQTTINWINN--NGgws 508
WP_011232175 267 PLPDMTKKALDVLSQ--------NK----KGFFLVVEEEAIDEMSHENNGSLMIKAGQQLDEAVAVAKQYAKR--HR--- 329
WP_012876236 262 SLPEMTQKAIDILSR--------NP----RGFFLFVEQEAIDEMGHNNNSELLMKAGQELDKSVGVALDYAKE--SG--- 324
WP_013370018 281 SLPDMTAKAIDVLSK--------NK----KGFFLMVEEEGTDEMAHDNEGELTIKAGQQLDKAVKVAKDYAKA--HP--- 343
WP_083835729 279 PLATMTAKALDVLSQ--------DR----HGFFLLVEEEGVDEMAHANNGALTLAAGQALDETVAVVRDFAQR--HR--- 341
WP_044276475 320 TAAEMTQMALELLRR--------HSeiagKPFFLVSEVESVDNLPNNANAIGGLRALKAADDTIGVIRQFIAE--NP--- 386
WP_014742192 272 PLADMTTKALDVLSE--------DE----DGFFLLVEEEAVDEMSHANNGTRMLQAMRSLDAAVEVAEAYVAE--HP--- 334
WP_082040101 324 TFAEMTEVTLTILNRaaasrtqpDQ----RRFFLVAEQESIDNFGNNTNAIGMLHAMQDTDRAIGAALNFQRSagNE--- 396
WP_106892078 255 RFDDMLAFALDRVRD--------AE----QGYLIVGNEEGTDNLSGENNVPATLEAAAGADRAIRLALNEHAK--NP--- 317
WP_105185466 296 RLPVMATKAIDLLSR--------DR----DGFFLFIEEEGIDEMAHHSNAKLMIKAGAELDRTVKIALDFAAR--TP--- 358
AFZ24373     509 KNLLLVTADHDHY-LTLn------------NDFPS-----KLT-AQdp------------------dVSRGl----kFNa 547
WP_011232175 330 DTLVLVLADHECGgLTIetpggtde----------------------------------sgdgktisGEDGpf------- 368
WP_012876236 325 DTLVLVTGDHECCgLTLegpddpk---------ypdedgrEIKgn--------------------isGEDGpf------- 368
WP_013370018 344 DTLVLVTADHETGgLAIegedaed------------------------------------esgegvsKEDGpf------- 380
WP_083835729 342 NTLVVVVGDHETGgLAVenvdpe----------------desgdPAstdpg------------vlqslEDGpf------- 386
WP_044276475 387 NTLLLTAADSDAGgMQIfspa--------pvdgNS-----RVT-TStgnptgf--------glnqgfpLDGi-----EGq 439
WP_014742192 335 DTLLIVTGDHECGgLTIedvdpedes----------gpggtlpqETaatg-------------gtesGEDGpf------- 384
WP_082040101 397 RTLILTAADSDAGnMTVlsgenvvpagsprSGILPpgtapNITgTVtsnpsavpttgttppstavtnfVDGv-----EGr 471
WP_106892078 318 ALTVVVCSDSDNGgMNAts------------ddLD-----ELPrpl------------------pkrSENGsllssdQGq 362
WP_105185466 359 GTLVLVVGDHETGgLAIenvdpnd------------------------------------engsgeqSEDTv-------- 394
AFZ24373     548 k--dI-Tf----------NkhnptdaghfwgSDPSKKYLWGSHSRRIVPVYYQGAYstTLTrflgqgfqmtdssgtynvp 614
WP_011232175 369 ---pI-Ars---------------------tQTFALDWTTTGHTAADVPLTAMGPGaeRFT------------------- 404
WP_012876236 369 ---kV-Ars---------------------sYRFKTDWTTTGHTPVDVPVSAYGPYadRLV------------------- 404
WP_013370018 381 ---tV-Kgs---------------------dEKFYIDWTTGGHTSVDVALTAMGPGssQFS------------------- 416
WP_083835729 387 ---pV-Ags---------------------dLQFTIDWTTSGHTGAATPLTAEGPGaeRLA------------------- 422
WP_044276475 440 ntapFlAapdafgneldfA----------------IGWVGTNDVAGGIVSRAEGLNaeLLRte----------------- 486
WP_014742192 385 ---lV-Ags--------------------edYDFALDWTTTGHTGAPTVVTAAGPGseQLT------------------- 421
WP_082040101 472 qspmFvTepdqfgnrmqfG----------------IIWPGSADYHGGILSRAAGLNagMLNsh----------------- 518
WP_106892078 363 ---pYlSaadargkripfY----------------VVWASNSDMAGGTVARGIGPGasVIH------------------- 404
WP_105185466 395 ---aI-Ahs---------------------nLKMVADWTTNGHTGAATPVTASGPGaqRLA------------------- 430
AFZ24373     615 girGVIDQSQIFQTMKTAL-T----SL 636
WP_011232175 405 ---GIYENTRIHDILEQLLfG----KS 424
WP_012876236 405 ---GNYENTHLHEVLQQAL-Gl---GP 424
WP_013370018 417 ---GNYPNTAIHDKLVKLL-Ql---KK 436
WP_083835729 423 ---RSQRNTDVFDVVLDAMhG----RR 442
WP_044276475 487 -frSRFDNTDVYRLMYATLfGellpAS 512
WP_014742192 422 ---GYYPNTHLHEVLREVLlG------ 439
WP_082040101 519 -fsARFDNIDVYRMKHATLfGrllnYP 544
WP_106892078 405 ---GTIDSTTIYQALRLGLfPqp---- 424
WP_105185466 431 ---GFIKNTQVHDAVLKAM-Gf---RR 450
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