Conserved Protein Domain Family
AprE

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COG1404: AprE 
Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]
Statistics
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PSSM-Id: 441014
Aligned: 824 rows
Threshold Bit Score: 90.9282
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_038564066    1 MAQGGEAVKRFSLLFISMFIIIGFQPVQAAEQRTVIIELEGDVSAYREYLEMHYPFIEIVEEFDTLFQGLALRATDAQLG 80  
WP_015177267  417 LKHVGALQQNLYLVATNMGLAPCALGSGDSDGFGQAAGLDYVEESAVGEFMLGSLPKRDVQASGVESVQEINLSDEPAEL 496 
WP_015171926   85 ARQAIQESRPFFSLTEVEIATQLPQVLLQELLELPTYQWLDKPQGTRSTVRPVSGVYTAIADSDEFEAVPEAAQAGFATT 164 
WP_050695373    1 ---------------------------------MVNPMHVFTPHPPRPHHVCVGWVGRAARVLTAAASVLALVVGALVLV 47  
WP_058258581    1 ---------------MKKYPTIIFGLVFIILSSMCIRNMSLADTYINIKNGEKVKDFEAGSLYKIKYKDKVKDVIVFNNG 65  
WP_050695285    1 --------------------------------MTHAQHTTPAAPRSPHPPRPLSGWVGRAARVLAAAASVLALAVGALVL 48  
WP_015191248      --------------------------------------------------------------------------------     
WP_011611949      --------------------------------------------------------------------------------     
WP_089612120   14 PVKGEYLIKFKEGYEGEKQVRNLSEIERFKHSKWVPKDNLLIFTFDEQAEKTHTMSEILDELNEDQTVEAVIPVFEDEEG 93  
AFZ23461          --------------------------------------------------------------------------------     
WP_038564066   81 KLSEHSHLLNIHQVHTYKAETRKsdvpfvtqefl---------------------------------------------- 114 
WP_015177267  497 AASESTVESDRGEAEPEPAEVGFrsstqptseldvgfrsstqatesvettevavsvseaesvsqtttqvmdseasese-- 574 
WP_015171926  165 TIHQDRQRILVLEASDFEAPAVDphrlkqslagricpalrdaqgmirylvplsvdlwfrpetprdrveailaalqlrlve 244 
WP_050695373   48 PASARADDVITTQEYFSYYHLDTarakg---------------------------------------------------- 75  
WP_058258581   66 KTEDYSASKHGSYFKSSKISEPLeklikedenqeltvaiwfkdidqtaiekeakellkiddinkidnktlqkyievkrel 145 
WP_050695285   49 VPARALADDVITTQEYFSYYHLDtarakg--------------------------------------------------- 77  
WP_015191248      --------------------------------------------------------------------------------     
WP_011611949      --------------------------------------------------------------------------------     
WP_089612120   94 FRRLVVPNRLLVAYHPGLKDALIdklagtysiaeqsrfgnwlilelpegveltsasenledipei--------------- 158 
AFZ23461          --------------------------------------------------------------------------------     
WP_038564066      --------------------------------------------------------------------------------     
WP_015177267  575 ----------------------------------------vesdvvvnetesaaisasgvessatplsaalhphdlddri 614 
WP_015171926  245 pvtetlaamgyyravipgcpvdtdplravlevvqlagqyeeirfaepeqiglndfgpdtthlagresdfeavgrywnhdv 324 
WP_050695373      --------------------------------------------------------------------------------     
WP_058258581  146 akvkyeslnkryydk--------ylpneevvfisnyapliivnikiykilklsefddilsfqlvekdekkeetsysipni 217 
WP_050695285      --------------------------------------------------------------------------------     
WP_015191248    1 --------------------------------------------------------mssltrnrsnisssaiaiqpihal 24  
WP_011611949    1 -------------------------------------------------------------------------mpeissi 7   
WP_089612120  159 -----------------------------------------------------dyiepvyygvndaeeistndvrwnlns 185 
AFZ23461        1 -----------------------------------------------------------mgygvsqitaevagfsdital 21  
WP_038564066  115 ----gtsaagvtgkgVKVGVIDTGI-DYTHPDLK-----K--N-YKGG--------FD--VV--Dw-DD----------- 157 
WP_015177267  615 pglahlrnqtlgdprITIVVIEGNP-DHSLSCFQ-----Sa-E-I-SkvfpywedtpE--PI--Ss-EEyatfraiedsd 680 
WP_015171926  325 iqlgaahqltqgsdkVTIFVIDSGV-DTEHPAIApvlrpDwqR-V------------DlnFTl-SdpESa---------- 379 
WP_050695373   76 ----------ytgkgVTIALIDGPV-DTSAPELK-----G--AnI-T----------Dk--SrcTi--E----------- 111 
WP_058258581  218 nanylrnnlnlrgsgIKVGIVEINYaDKSNSQLN-----D--RnII----------FD---V--S--DAv---------- 263 
WP_050695285   78 ----------ytgkgVTIALIDGPV-DTSAPELK-----G--AnI-T----------Dk--SrcTi--E----------- 113 
WP_015191248   25 sglrslysetfgdpqICIAVLDSSV-DQSHPCFE-----Ga-N-L-Tql-------qT--LV--Sg-FA----------- 72  
WP_011611949    8 pgikqlwaktkgnseVCVAVLDGLV-DLKHPCFE-----Ga-N-L-Tql-------pS--LV--Qg-QAt---------- 56  
WP_089612120  186 inindawtitkgnpeILIAVIDGKP-DISHPSLK-----Q--S-FQQGls----ddWD--FA------------------ 232 
AFZ23461       22 pglqslwaeslgnprICVAVLDGLV-DQSHPCFD-----Ga-Q-F-Trl-------pT--LV--Sg-VA----------- 69  
WP_038564066  158 -------------------DPME-TtpeEGevtiHGTHVAGIIGANG-----KMKGIAPDAEIYSYRA-LGP-G--G--- 205 
WP_015177267  681 rtkkekeeslkaafpetliQRLK-V---DD----HTCHVTSIIVGQEn---tPSAGIAPHCRLINLSL-TSGiAe----e 744 
WP_015171926  380 ------------------lSPQEiS---VS----HGTQVTSVAIAQGpengeIVRGIAPLCRVLPIKI-SGS-M--G--- 427 
WP_050695373  112 -------------------PSPA-S---KS----HGTAMASFLVSR-------DYGVAPDATLHAYQA-RAS-Ed----p 151 
WP_058258581  264 -------------------ASQD-T---GS----HATKVASIIVGR-------TQGIVPDATVYMTAAk-NR-------- 300 
WP_050695285  114 -------------------PSAS-N---RT----HATSLASFLVSH-------DYGVAPDATLHTYQV-ANK-Ss----v 153 
WP_015191248   73 -------------------KSGS-V---AQ----HGTHIASIIFGQPn---sSVPGIAPGCRGLTVPV-FAD-Gq-Eglv 119 
WP_011611949   57 -------------------PQSE-M---SL----HGTHVASIIFGQPn---sSVSGIAPHCRGLIVPI-FSD-Y--Hr-- 100 
WP_089612120  233 ----------------------DnSi-fSS----HSTQILSILTGQRd----dLQGISPLSRIISLSVnL-N-A------ 273 
AFZ23461       70 -------------------DQGT-A---SQ----HGTHVTSVIFGQHg---sPIRGIAPGCRGLIVPV-FTN-GsqGgvt 117 
WP_038564066  206 T-G-T-SVQ---V---IAAIEKA-V---E-DKMD--IINLSLGSSVng--pDW--PTSLAVNK-AVEMGVSVVTANGNEG 264 
WP_015177267  745 Y-I-S-PLN---L---ARAFEQA-L---D-LGAN--IIHCGICHPTktgegEE--LFAKAVQK-CLDNNILIVGPAGNGL 805 
WP_015171926  428 Y-GlR-AAA---I---RQAI--AlLqpgE-RG----ILNLSWRTNG------EhiGIREALQE-ADRRGFATVTSAGNYS 485 
WP_050695373  152 SgG-TcQKGeemLntfGKLINQA-I---D-DGAQ--IISISKGGDDt----TF--ELKWAIAR-AMREGVIIVNSAGNTG 216 
WP_058258581  301 ------LED-------YEKIEWL-M---D-QGVS--VINYSAGYSTgaglySD---MAKwIDHlSFQHNITFVKSSGNGG 357 
WP_050695285  154 SpG-ScSADgkrLdsySKVINQA-I---D-DGAQ--IISISQSSTDh----RD--ELKWTIAR-AMSLGVIIVNSAGNTG 218 
WP_015191248  120 P-C-S-QLD---L---ARAITQA-V---E-QGAN--VINISGGQLTqsgepDP--FLTNAIQL-CRENNVLIVAATGNDG 180 
WP_011611949  101 R-T-S-QLN---L---ARAIEQA-V---N-AGAN--IINISGGELTdygeaED--WLNRAVSL-CQNNNVLLVAAAGNDG 161 
WP_089612120  274 QyyhQ-RAEa--Iy-yLKSIMEArLl--DvQpVKrvVANCSWKTSGd----vR--IIREAIQE-AAAAGVIFVTSAGNEN 340 
AFZ23461      118 P-C-S-QID---L---ARAITQA-V---E-QGAN--VINISGGQLAassesDK--LLANAVRL-CADNNVLIVAAAGNDG 178 
WP_038564066  265 Pa-nW-T--VGSPAT----A----T---KAL-SVGAVTTpqktavlyerfykklipilplqgavewkqrrslpimdggtg 328 
WP_015177267  806 G---E-Y--WCLPGV----L----P---GTL-PVGAMDL----------------------------------------- 826 
WP_015171926  486 AgerQiAndLHYPSAhgyrY----PylrS-LcVVAASTV----------------------------------------- 519 
WP_050695373  217 Ad--A-N--YNQLSG----R----S---GVV-GVSAITS----------------------------------------- 238 
WP_058258581  358 Dn--S-Y--ITDPGM----A----Y---NGI-TVSSIND----------------------------------------- 379 
WP_050695285  219 Ad--N-N--EQQLSW----W----S---GVV-GVSAITS----------------------------------------- 240 
WP_015191248  181 C---A-C--LHFPAA----I----A---SVL-AVGAMNA----------------------------------------- 201 
WP_011611949  162 C---E-C--LHVPAA----L----P---TVL-AAGAMGE----------------------------------------- 182 
WP_089612120  341 Ts----G--AHYPSD----YsktiN---GVF-SVAALAP----------------------------------------- 365 
AFZ23461      179 C---D-C--LHVPAA----L----E---SVL-AVGAMDF----------------------------------------- 199 
WP_038564066  329 erqlpdatgkivifkrgkipfaekariaeranavavliyndgsgpleasiqdggkpvsipvaavtrqDglwllknkqtaq 408 
WP_015177267  827 -------------------------------------------------------------------G------------ 827 
WP_015171926  520 -------------------------------------------------------------------E------------ 520 
WP_050695373  239 -------------------------------------------------------------------D------------ 239 
WP_058258581  380 -------------------------------------------------------------------N------------ 380 
WP_050695285  241 -------------------------------------------------------------------D------------ 241 
WP_015191248  202 -------------------------------------------------------------------Q------------ 202 
WP_011611949  183 -------------------------------------------------------------------N------------ 183 
WP_089612120  366 -------------------------------------------------------------------S------------ 366 
AFZ23461      200 -------------------------------------------------------------------S------------ 200 
WP_038564066  409 lsakqielqNRM-------AAFSSRGPvtrn-waiKPE---ISAPG--------AP-------VWS-T-VPQSGYQAL-Q 459 
WP_015177267  828 ---------SPP-------AHYSNWGG--------NYTeegIMAPG--------DD-------IWG-A-QLATEKPRLrT 866 
WP_015171926  521 ---------NRR-------ASYSYFGSe-------SIT---LAAPG--------GEagsagsaIYV-A-SPRGQHAYV-W 563 
WP_050695373  240 ---------GKF-------AKYSSWGN--------GVT---TAAFG--------GP-------ATFrD-YITGNAKTG-E 275 
WP_058258581  381 ---------NSFnepnwndDSFSNYSSfleieggyKPD---LSAPG--------ED-------I-SvA----G-FLGS-N 426 
WP_050695285  242 ---------GKF-------ADYSSWGN--------GVT---TAAIG--------GP-------VTArN-YETGSNESK-S 277 
WP_015191248  203 ---------SQP-------MRFSNWGE--------AYQtngILAPG--------EN-------ILG-A-VPGGGTAAK-T 240 
WP_011611949  184 ---------GQP-------LDYSNWGE--------NYQtqgILALG--------EN-------ILG-A-EPGGGTRQL-S 221 
WP_089612120  367 ---------GRK-------ADYSNYSP--------TVT---ISAPGgagqpfddDD-------IYC-AdL-NNSTAFV-A 409 
AFZ23461      201 ---------GNP-------IGFSNWGE--------VYRsqgILAPG--------EN-------ILG-A-IPGGGTATR-S 238 
WP_038564066  460 GTSMAAPYVAGALALVKEAH------PEW--TD-EQ--------------QI---------------GAL---------- 491 
WP_015177267  867 GTSGAAPIVTGIAALLMSLQlqegkpVD----A-EAvrtal--------------------------------------- 902 
WP_015171926  564 GTSFAAPHVAGLLGLMFARN------PQL--SA-PEaiacl----qrtaqSLpasep-----aplghGIVnayaavmavp 625 
WP_050695373  276 GTSVAAALTSGMLALARQKW------PDA--TA-NQllqvl----thtglNPnhqwd-----kytgyGAIn--------- 328 
WP_058258581  427 GTSFSAAHVTGVIAQILQSS------PDLifKPcAlnailkagtlhktanDYnfysmipdysnregaGVIdakgayqsan 500 
WP_050695285  278 GTSNAAPLVAGMLALARQKW------PDA--TA-NQilqvl----trtglNPnhqwd-----kytgyGAAs--------- 330 
WP_015191248  241 GTSFAAPIVSGIAALLLSIQlqrgekPD----P-HAirdai----lqsalPCdpakssd--srrclvGKLnisgayalit 309 
WP_011611949  222 GTSFATPVVSGVAALLMSLQlqreekPD----S-QKvrtal----lktavPChaqek-----rrclvGQMnisgaiahit 287 
WP_089612120  410 GTSFAAPHVAGVIALMLSVN------PAL--DI-ESisdil----vrtavPIseqnpgn--wqylgaGKLda-------- 466 
AFZ23461      239 GTSFATPIVSGLVALLLSIQlqrgqkPD----P-HAirdai--------------------------------------- 274 
WP_038564066  492 --------------------------------------------------------LTTAQLLKKPNGQHYDPIEQGMGK 515 
WP_015177267  903 ----------------------------------------------------lktaIPCDPKVVEEPERCLRGFVNIGGA 930 
WP_015171926  626 lpqevsenppaeppqeihhagkinlntataeelaklslmndwridhllryrqtqgplqsiwdllyagafdlwtirhlqdq 705 
WP_050695373  329 --------------------------------------------------------GGALVNTDPSQYPDENPLAQKEGG 352 
WP_058258581  501 asnyiqvqldnglfpysypitinytsspvrivlnwhkqnsilnngsidlrnisdmdlyiidpngqivaasttannntemv 580 
WP_050695285  331 -------------------------------------------------------iSDLVNTDPSQYPDENPLAQKEGGS 355 
WP_015191248  310 kgkikqmsheklenvmm------------qpsetdntiaqlqpsemlmvtgnetntAVTPSECATCGGKSEASEGSEAKQ 377 
WP_011611949  288 getmseseqdnsngieascgcestpeaslpgsvglenslptpadngvvaagvveagVTASQPLSSTNTSNTSNNQISAMP 367 
WP_089612120  467 -------------------------------------------------------gKAMDEIRKNNEIITEPTDTDIPDQ 491 
AFZ23461      275 ----------------------------------------------------lktaLPCNLQKSLDSRRCLVGSLNIAGV 302 
WP_038564066  516 MQPSKAISTPVIIENPLLRFGKIDTKQDAEYVLTVHNVSNVRQQLQFDQPKAVSGIRWKVPMSVDLSPHETKRLNI 591 
WP_015177267  931 MKLLFGRPSFTISFAGDRVTRTERGGYAMATATAAPASIAAAMTDTAVSPALQPATPATLTEEPVTAAATPADTGT 1006
WP_015171926  706 vsl------------------------------------------------------------------------- 708 
WP_050695373  353 SNPTVEEVQDYADGLADPRYVGSHDSYVYRGIDETLLNLVDPDSSAPIHLGTSPKYHRK----------------- 411 
WP_058258581  581 eftptvkgtytvivdgyilentyevfglawyqk------------------------------------------- 613 
WP_050695285  356 KPTASEVQDYADGLIPPSDDITLDPSYSYRGTDETLLWLPENGTPIHLGTSPKYHRK------------------- 412 
WP_015191248  378 APQIPLAYALGELGTDFGTQARQDSFMQAIPAGMNLLDYLDQNPWEAQSLIWTLNLDATPIYAIMPMGAYANVVYE 453 
WP_011611949  368 NNSQSNNSNGITPSQPPQDVTNIVYVIGTLGYDFGTEARRDSFKQLMPAVTIGNTQIPANPYDARQMVDYLANNLS 443 
WP_089612120  492 HGGPKINITIADDTFDNIDTDLFAKEICNRACMEINQLSGNWVLGSNVRITINDSNGSSVILNYTI---------- 557 
AFZ23461      303 EALIKKEGIQQMSNQEEVMIQPSEVNNIEQEVINQLTEPVMQIPNLQESSYSIPMMNLQPASANVVPSSVAPSECT 378 
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