Conserved Protein Domain Family
PRK09238

?
PRK09238: PRK09238 
bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated
Statistics
?
PSSM-Id: 236424
Aligned: 382 rows
Threshold Bit Score: 1050.15
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
119387292   3 LYTDYLTEIETR-KGQGLHPKPIEDGAlVAELIAQIEDAGSEyRDDSLNFFIYNTLPGTTSAAGVKAAFLKKIIVGEAIV 81  
196158221   3 LYSEYLAEIETRkTELGLNPKPIDSAElLSEIIAQIKDTTNEhREDSLKFFIYNTLPGTTPAAGVKAQFLKEIVLGEEKV 82  
146299711   3 IYKDYIQEIEER-KNQGLHPKPIDSAElLSEIIAQIKDTNNEyREDSLKFFIYNTLPGTTSAAGEKAKFLKEIILGQSVV 81  
159186297   3 LYLDYLAEIKSR-ETLGLAPKPIDDGAlTAEIIELIEDTSSEyRAdALKFFIYNTLPGTTSAAGVKAAFLKQIILGEVLV 81  
254295052   3 LYNDYLNEIANR-KNEGLNPKPIDDGAlVKEIISQIKDTQNEhRESSLKFFIYNTLPGTTSAAGEKALFLKEIILGDASV 81  
148555644   3 IYLDYLAEIESR-KIQGLAPKPIDDGGlVFEIIAIIRDAGSEhRADALKFFIYNTLPGTTSAAAVKAGFLKQIILGDAVV 81  
71280538    3 LYSEYIKEIESRkTDLGLAPLPIDSADlLSEIIAQIKDSANAhREESLNFFIYNTLPGTTSAAGVKATFLKEIILAESVV 82  
256421115   3 RYNEYLKEIEER-KGQELHPKPIDGAElLNEIIEQIRDLANVhRKDSLNFFIYNVLPGTTSAAGVKAKFLKEIILGTAKV 81  
255035002   3 IYQDYIKEIEER-KTQGLHPKPIDSAElLGEIIAQIKDQANEyRDDSLKFFIYNTLPGTTSAAGVKARFLKEIILGESVV 81  
159044604   3 LYTAYLEEIAAR-KEQGLQPKPIDDAAlTSEIIAQIKDPAHEhRAdSLQFFIYNTLPGTTSAAGAKAQFLKEIILGESVV 81  
119387292  82 PEIAPAFAFELLSHMKGGPSVEILLDLAL--GEDaaIAQQAAEVLKTQVFLYDAdMARLGMAYEAGNAVAKDILESYAKA 159 
196158221  83 EEITPEFALELLSHMKGGPSVEALLDLAL--SDDeaVANPAAEVLKTQVYLYEAdTERLETAYKAGNAIAKDVLESYAKA 160 
146299711  82 AEITPAFAFELLSHMKGGPSIEVLLDLALgnDAA--IAKEAAKVLKTQVFLYEAdTDRLVEAFKNNNTIAKEILESYAQA 159 
159186297  82 PEITPSFALELLSHMKGGPSIKVLLDVALgnDAA--IDAKAGEVLKTQVFLYDAdMFRLRDAYKEGSAIARDVLESYAKA 159 
254295052  82 EEISTDFAFELLSHMKGGPSVEVLLDIAL--GDDaaIAGKAADVLKTQVFLYDAdTARLADAYKAGNAIAADILKSYAKA 159 
148555644  82 PEITPAFALELLSHMKGGPSVEVLLDIAL--GDApaIAALAGEVLKTQVFLYDAdMHRLSEAFGAGNAIARDILESYAKA 159 
71280538   83 AEITPTFAFELLSHMKGGPSIEVLLDLAL--SDDaaVAKEAAEVLKTQVFLYDAdTARLEAAFKAGNALAKEILESYAQA 160 
256421115  82 EEITPAFAFELLSHMKGGPSIEVLLDLALgnDAA--IAKEAAKVLKTQVFLYDAdTDRLKEAFKNENPIAREIIESYAQA 159 
255035002  82 EEISPAFAFELLSHMKGGPSISVLLDLALgeDAE--IAKQAADVLKTQVFLYDAdTDRLKEAFKSGSEIAKEILESYAKA 159 
159044604  82 AEITPDFAFELLSHMRGGPSVEVLLDIALgdDAS--LAAQAAEVLKTQVFLYEAdTDRLKAAHEAGNAVATGILQSYARA 159 
119387292 160 EFFTELPGIEEEIKVVTYIAaEGDISTDLLSPGNQAHSRSDRELHGQCMISPEAQREIQALQKQHPDKRV----MLIAeK 235 
196158221 161 EFFTKLPDVPEKIEVVTYIAaEGDISTDLLSPGNQAHSRADRELHGKCMITPEAQQEIVELGKKHPNAKV----MLIAeK 236 
146299711 160 EFFTKLPEVADEIKVVTFIAgEGDISTDLLSPGNQAHSRSDRELHGQCMITPQAQQEIKALQAQHPDKSV----MLIAeK 235 
159186297 160 EFFTKLPDVDDEIKIVTFIAaEGDISTDLLSPGNQAHSRSDRQLHGQCMISPEAQAEIVALQQQHPDKRV----MLIAeK 235 
254295052 160 EFFTKLPDIEEEIKVVTYIAgEGDISTDLLSPGNQAHSRSDRELHGKCMITPEAQTEIQELQKKHPEARV----MLIAeK 235 
148555644 160 EFFTKLPEVEDEIEVVTFIAgEGDISTDLLSPGNQAHSRSDRELHGQCMISPEAQQAIVALKAQHPGKRV----MLIAeK 235 
71280538  161 EFFTKLPNVEEKVEVVTYIAgEGDISTDLLSPGHQAHSRADRELHGQCMSTPEAQAEILALQVKHPNAKV----MLIAeK 236 
256421115 160 EFFTKLPEVPEEIKVVTFIAgEGDISTDLLSPGNQAHSRSDRELHGKCMITPAAQAEIKKLQAEHPDKSV----MLIAdK 235 
255035002 160 EFFTKLPEVPEEIKIVTFIAgEGDISTDLLSPGNQAHSRSDRELHGQCMITPKAQQEIKLLQEEHPDKSV----MLIAeK 235 
159044604 160 EFFTTLPEIEDEIEVVTYIAaEGDISTDLLSPGNQAHSRSDRELHGKCMISEAAQK---EIEALKLQ-HPgkrvMLIAeK 235 
119387292 236 GTMGVGSSRMSGVNNVALWTGKKAsPYVPFVNIAPVVAGTNgISPIFLTTVGVTGGIGIDLknwvrktdedgkpilnndg 315 
196158221 237 GTMGVGSSRMSGVNNVALWAGEPTsPYIPFVNKAPIVAGTNgIAPIFLTTVDVTGGIGLDLknwvkktdengeivrdang 316 
146299711 236 GTMGVGSSRMSGVNNVALWTGKQAsPYIPFVNIAPIVGGTNgISPIFLTTVDVTGGIGLDLknwvkkvdadgnvirnend 315 
159186297 236 GTMGVGSSRMSGVNNVALWTGKQAsPYVPFVNYAPIVAGTNgISPIFATTVDVTGGIGINLknwvkklgedgkpilnndg 315 
254295052 236 GTMGVGSSRMSGVNNVALWAGKQAsPYVPFVNIAPVVAGTNgISPIFLTTVGVTGGIGLDLknwvkktdangnvvkdeng 315 
148555644 236 GTMGVGSSRMSGVNNVALWTGKQQsPYVPFVNYAPVVAGTNgISPIFATTVDVTGGIGINLknwvkqtgpdgnpilnndg 315 
71280538  237 GTMGVGSSRMSGVNNVALLAGKKAsPYVPFINIAPVVAGTNgISPIFLTTVDVTGGIGLDLknwvkkvdangnavvdang 316 
256421115 236 GTMGVGSSRMSGVNNVALWTGKQAsPYVPFVNIAPIVGGTNgISPIFLTTVDVTGGIGIDLknwvkkvdengklirneag 315 
255035002 236 GTMGVGSSRMSGVNNVALWTGKQAsPYVPFVNIAPIVGGTNgISPIFLTTVDVTGGIGIDLknwvkktdehgnvvrneng 315 
159044604 236 GTMGVGSSRMSGVNNVALWTGKQAsPYVPFVNIAPVVAGTNgISPIFMTTVGVTGGIGIDLknwvkkvdgdgnpilnndg 315 
119387292 316 npileQKYSVETGTVLTINTRDKKLYD-ETGtrDLVDVASAFTPQKVEFMKAGGSYAIVFGKKLQTFAAETLGIEPTPVF 394 
196158221 317 dpvleEAYSVATGTVLTIDTKAKKLFn-GSE--ELADVSASFTPQKMEFMKAGGSYAVVFGKQLQSFAARTLGVEAPAVY 393 
146299711 316 epileQTYSVATGTVLTINIKEKKLYN--GDq-ELIDISKAFTPQKMEFIKAGGSYAIVFGKKLQTLAAKVLDVEAPLVY 392 
159186297 316 npileQKYSVETGTVLKIDAKNRKLRD-ENGt-ELVDLASSFTPQKMEFMKAGSSYAIVFGKKLQTFAAQTLGVEATQVF 393 
254295052 316 dvvleEAYSVATGTVLTINTKEKKLYN-GDK--ELADISSAFTPQKVEFMKAGGSYAVVFGKKLQTFAAATLGQELKSAY 392 
148555644 316 npvleEKFSVETGTVLKIDVRNKKLRGeDGA--ELVDIASSFTPQKMEFMKAGSSYAIVFGKKLQTFAARTLGVEPVPVF 393 
71280538  317 davleEAYSVATGTVLTIDTKAKKLYN-GDK--ELADISSAFTPQKVEFMKAGGSYAVTFGKKLQTFAAETLGLATPPVY 393 
256421115 316 ehileEVYSVATGTVLTINTKKKKLYN--GDk-ELIDISKALTPQKMEFIRAGGSYAIVFGKKIQTIAAKLLNIEIPPVF 392 
255035002 316 dpvleEVYSVATGTVLTINTKTKKLYNgEQE---LIDISKALTPQKKEFIRAGGSYAIVFGKKIQTVAAKILGIEPTPVF 392 
159044604 316 npileQKYSVDTGTVLKIDTKARKLMSaDGGe-ELADVSSAFSPQAVEFMKAGGSYAVVFGKKLQTLAAETLGVEPTPVF 394 
119387292 395 APNKEISREGQGLTAVEKIfnrnaVG-VTPGK----VLHAGSDVRVRVNIVGSQDTTGLMTAQELEAMAAtvISPILDGA 469 
196158221 394 AQSKEVSHEGQGLTAVEKI-----FNrNAVGVnsdaPLHAGSDVRVKVNIVGSQDTTGPMTCQELESMAAstISPTVDGA 468 
146299711 393 APSKEVSYEGQGLTAVEKI-----FNkNAVGIapgkVLHAGSDVRVEVNIVGSQDTTGLMTAQELESMAAtvISPIVDGA 467 
159186297 394 APNKEISIEGQGLTAVEKI-----FNrNAVGVtpgkVLHAGSDVRVKVNIVGSQDTTGLMTAQELEAMAAtvISPLVDGA 468 
254295052 393 APAKEISHKGQGLTAVEKIfnknaVG-TTPGA----TLHAGSDVRVEVNIVGSQDTTGLMTCQELESMAAtvISPIVDGG 467 
148555644 394 AANKEITVEGQGLTAVEKI-----FNrNAVGVtpgkVLHAGSDVRVKVNIVGSQDTTGLMTAQELEAMAAtvISPLVDGA 468 
71280538  394 ATSKEISHEGQGLTAVEKIfnnnaVG-VTSET----PLHAGSDVRVKVNIVGSQDTTGPMTCQELEAMAAstISPLVDGA 468 
256421115 393 AQPKEISHEGQGLTAVEKI-----FNrNAVGTtpgkVLHAGSDVRVEVNIVGSQDTTGLMTAQELESMAAtvISPIVDGA 467 
255035002 393 APSKEISNEGQGLTAVEKI-----FNkNAVGVtpgkILHAGSDVRVEVNIVGSQDTTGLMTAQELESMAAtvISPIVDGA 467 
159044604 395 APAKEISHEGQGLTAVEKI-----FNaNARGVtpgkVLHAGSDVRVQVNIVGSQDTTGLMTSQELEAMAAtvLSPTVDGA 469 
119387292 470 YQSGCHTASVWDAKAQANIPKLMAFMNNFGLITARDPKGvyhamtdVIHKVLNDITVDDwAIIIGGDSHTRMSKGVAFGA 549 
196158221 469 YQSGCHTASVWDKKAQANIPKLMSFMNNFGVITARDPKGvyhamtdVIHKVLNDITVDDrAIIIGGDSHTRMSKGVAFGA 548 
146299711 468 YQSGCHTASVWDKKAQANIPKLMKFMNDFGLITARDPKGvyhsmtdVIHKVLNDITIDEwAIIIGGDSHTRMSKGVAFGA 547 
159186297 469 YQSGCHTASVWDKKAQANTPKLMSFMHNFGVITGRDPKGvyhsmtdVIHKVLNDITVDDrAIIIGGDSHTRMSKGVAFGA 548 
254295052 468 YQSGCHTASVWDIKARENIPKLMSFMNKFGMITARDPADkyapltdVIHKVLNDLTVDDwDIIIGGDSHTRMSKGVAFGA 547 
148555644 469 YQSGCHTASVWDKKAQANIPKLMSFMNNFGLITARDPKGayhpmtdVIHKVLNDITVDDwAIIIGGDSHTRMSKGVAFGA 548 
71280538  469 YQSGCHTASVWDSKAKANIPKLMAFMNKFGLITARDPKGvyhamtdVIHKVLNDITVDDrAIIIGGDSHTRMSKGVAFGA 548 
256421115 468 YQSGCHTASVWDKKAQANIPKLMKFMNEFGLITARDPKGeyhsmtdVIHKVLNDITVDEwAIIIGGDSHTRMSKGVAFGA 547 
255035002 468 YQSGCHTASVWDKKAQANIPKLMKFMNDFGLITARDPKGeyhsmtdVIHKVLNDITVDEwAIIIGGDSHTRMSKGVAFGA 547 
159044604 470 YQSGCHTASVWDLKAQANTPRLMAFMHKFGLITARDPKGvyhsmtdVIHKVLNDITVSDwDIIIGGDSHTRMSKGVAFGA 549 
119387292 550 DSGTVALALATGEATMPIPESVKVTFKGTMQPHMDFRDVVHATQAQMLKQ-CGDNVFQGRVIEVHIGTLLADQAFTFTDW 628 
196158221 549 DSGTVALALATGEAAMPIPESVKVTFKGSMKEHMDFRDVVHATQAQMLKQfAGENVFQGRVIEVQIGTLLADQAFTFTDW 628 
146299711 548 DSGTVALALATGEASMPIPESVKVTFKGDMKGYMDFRDVVHATQAQMLHQfGGENVFQGRIIEVHIGTLTADQAFTFTDW 627 
159186297 549 DSGTVALALATGEATMPIPQSVKVTFKGTMQPYMDFRDVVHATQAQMLQQ-HGDNVFQGRIIEVHIGTLLADQAFTFTDW 627 
254295052 548 DSGTVALALATGEATMPIPESVKVTFKGTLKDHMDFRDVVHATQAQMLAQ-FGDNVFQGHVIEVHIGTLLSDQAFTFTDW 626 
148555644 549 DSGTVALALATGEATMPIPQSVKVTFKGKMQPHMDFRDVVHATQAQMLQQcGGENVFQGRIIEVHIGTLLADQAFTFTDW 628 
71280538  549 DSGTVAIALATGESAMPIPESVKVTFKGNMQGHMDFRDVVHATQAQMLKQfGGENVFQGRIIEVHIGTLLADQAFTFTDW 628 
256421115 548 DSGTVALALATGEASMPIPESVKVTFKGEMKDHMDFRDVVHATQAQMLQkfAGENVFQGRVIEVHIGTLPADQAFTFTDW 627 
255035002 548 DSGTVAIALATGEASMPIPESVKVTFKGSMKEHMDFRDVVHATQAQMLQQfGGENVFQGRIIEVHIGTLPADQAFTFTDW 627 
159044604 550 DSGTVALALATGEATMPIPESVKVTFKGKMADHMDFRDVVHATQAQMLAQ-HGDNVFQGRVIEVHIGTLLADQAFTFTDW 628 
119387292 629 TAEMKAKASICISQDETLIESLEIAKSRIQIMIDKGMENAAGTlhgliakaDKRIAEIRS--GEKPALAPDENAKYFAEV 706 
196158221 629 SAEMKAKASICISDNETMVASLELAKSRIQIMIDKGMDNEANMlqglidlaDKRIAEIKS--GEVPALAPDDNAKYYAEV 706 
146299711 628 TAEMKAKASICISEDDTLIESLEIAKGRIQIMIDKGMDNDKHVlqglinkaDKRIAEIKS--AEKPALTPDANAKYYAEV 705 
159186297 628 TAEMKAKASICISEDETLIESLEIAKSRIQIMIDKGMDNAAQTlkglidkaDQRIAEIRSg-ETPAL-KPDANAKYFAEV 705 
254295052 627 SAEMKAKASICISESDTLVESLEIAKSRIQIMIDKGMDNEGKVlqglidkaDKRIAGIKSgaQPP--LNPDDNAKYFAEV 704 
148555644 629 TAEMKAKASICISDDETLIGSLEIAKARIQIMIDKGMDNAAGTlanliakaDTRIAEIRl--GEKPALSPDDNAKYFAEI 706 
71280538  629 SAEMKAKASICISEDETLIQSLELAKSRIQIMINKGMENEAKTlnglialaDKRIEGIKS--GETPALAPDDNATYYAEV 706 
256421115 628 TAEMKAKASICISEDDTLIQSLEIAKGRIQIMIDKGMDNSRQVlqglinraDKRIAEIKS--GEKPALTPDENAKYYAEV 705 
255035002 628 TAEMKAKASICISEDDTLIESLEIAKNRIQIMIDKGMENHKQVlqglinraEKRIAEIKS--GEKPALTPDVNAKYYAEV 705 
159044604 629 TAEMKAKASICISNDDTLIESLEIAKQRIQVMIDKGMDNDVQMlagliakaNARIAEIRS--GEKPALKPDDTARYFAEV 706 
119387292 707 VVDLDLIDEPMIADPDvnnadvskryTHDTIRPVSYYGA-RkKVDLGFVGSCMVHKGDIKIVAQMLKNLEkSqgkvEFKA 785 
196158221 707 VIDLDQIDEPMIADPDvnnedvskryTHDVIRPVSYYDG-K-PVDLGFVGSCMVHKGDMQIIAQMLRNLEkLngsvEFKA 784 
146299711 706 VVDLDLIAEPMIADPDvnnadvskryTHDTIRPLSFYGGvK-KVDLGFIGSCMVHKGDMKILAQMLKNVEaQtgkvEFNA 784 
159186297 706 VVDLDIINEPMIADPDvnnndvsrryTHDTIRPVSYYGAt-kKVDLGFVGSCMVHKGDVKIVAQMLRNMEkTegkvEFKA 784 
254295052 705 VIDLDEIVEPMIADPDvnnedvskryTHDTIRPVSYYGG-TkTVDLGFIGSCMVHKGDMKILSEMLQNLEkQngkvEFQA 783 
148555644 707 VVDLDVIDEPMIADPDvnnpdvskryTHDTIRPVSYYGGtK-KVDLGFIGSCMVHKGDMKILAQMLKNIEaAegkvEFKA 785 
71280538  707 VIDLDVIDQPMIADPDvnnedaskryTHDVIRPVSYYAD-K-SVDLGFVGSCMVHKGDMQIIAQMFRNMEaQgnkiEFKA 784 
256421115 706 VIDLDAIVEPMIADPDvnnddvakryTHDTIRALSYYSG-EkKVDLGFVGSCMVHKGDLKIVSQMLRNLEnQngkvEFNA 784 
255035002 706 VIDLDVIVEPMIADPDvnnkdvskryTHDTIRPISFYGD-EkKVDLGFVGSCMVHKGDLKIVSQMLKNLEeQqgkvEFHA 784 
159044604 707 VVDLDQIVEPMIADPDvhnadvskryTHDTIRPISYYGAeK-KIDLGFVGSCMVHKGDVKIVAQMLRNLEkAngevKFKA 785 
119387292 786 PLVVAAPTYNIIDELKAEGDWEILQKYSGfefddllpkskarteyenilYLERPGCNLCMGNQEKAAKGDTVLATSTRLF 865 
196158221 785 PLVVAPPTYNIVDELKAEGDWEVLAKYAGfefddakpkeaartkydnilYLERPGCNLCMGNQEKAEPGDTVIATSTRLF 864 
146299711 785 PLVVAPPTYNIVDELKAEGDWEVLQKYSGfefddnapkgaarteyenmlYLERPGCNLCMGNQEKAAKGDTVMATSTRLF 864 
159186297 785 PLVVAAPTYNIIDELKAEGDWEILQKYSGfefddvnpktsnrteydnilYLERPGCNLCMGNQEKAAKGDTVLATSTRLF 864 
254295052 784 PLVVAPPTYNIVDELKAEGDWDVLKKYAGfefddtapkaaarteyenmlYLERPGCNLCMGNQEKAAKGDTVMATSTRLF 863 
148555644 786 PLVVAPPTYNIVDELKAEGDWEILQKYSGfefddenpkaasrteyenilYLERPGCNLCMGNQEKAAKGDTVLATSTRLF 865 
71280538  785 PLVVAPPTYNIVDELKAEGDWDILQKYSGfefddavpknaartkyenimYLERPGCNLCMGNQEKAEPGDTVIATSTRLF 864 
256421115 785 PLVVAAPTYNIIDELQVEGDWEILQKYSGfefndnapkgaarteyenmmYLERPGCNLCMGNQEKAAKGDTVMATSTRLF 864 
255035002 785 PLVVAAPTYNIIEELKSEGDWDVLQKYSGfefddnapkvaarteyenmmYLERPGCNLCMGNQEKAAKGDTVLATSTRLF 864 
159044604 786 PLVLAAPTYNIIDELKEEGDWDVLQKYAGfefddsapkekarteyenilYLERPGCNLCMGNQEKAAKGDTVLATSTRLF 865 
119387292 866 QGRVvedtaEKKGESLLASTPVVVLSAILGRTPSAEEYKAAVEGIDLTrfapplekPETSRSVH-F 930 
196158221 865 QGRVvadsdEKKGESLLGSTPLVVLSTVLGRFPTTEEYKQAVEGIDLTkfappsedlavkpkfead 930 
146299711 865 QGRVvedkeGKKGESLLSSTPVVVLSTILGRTPTIEEYTAAVDGINLTkfapsnkslvm------- 923 
159186297 865 QGRVvedsaEKKGESLLASTPVVVLSAILGRTPSIEEYRSAVEGIDLTk----------------F 914 
254295052 864 QGRVvedtdNKKGESLLASTPVVVLSTILGRVPNMEEYKAAVEGINLTsyappln----------- 918 
148555644 866 QGRVvedsaNKKGESLLASTPVVVLSTILGRTPSADEYKAAVDGIDLTkfappkaa---------- 921 
71280538  865 QGRVvadtaEKKGESLLGSTPLVVLSTMLGRFPSIEEYKSAVEGIDLT-----------RFAPPtH 919 
256421115 865 QGRVvedsdRKKGESLLASTPVVVLSAILGRIPNMEEYKAAVVGIDLTk------fAPP------L 918 
255035002 865 QGRVvedseRKKGESLLASTPVVVLSAILGRIPNISEYKAAVEGIDLTk------fAPP------I 918 
159044604 866 QGRVvadseTKKGESLLGSTPVVVLSAILGRTPTVEEYKTAVEGINLTk----------------F 915 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap