1V9F


Conserved Protein Domain Family
rluA_subfam
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TIGR00005: rluA_subfam 
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pseudouridine synthase, RluA family
In E. coli, RluD (SfhB) modifies uridine to pseudouridine at 23S RNA U1911, 1915, and 1917, RluC modifies 955, 2504 and 2580, and RluA modifies U746 and tRNA U32. An additional homolog from E. coli outside this family, TruC (SP|Q46918), modifies uracil-65 in transfer RNAs to pseudouridine. [Protein synthesis, tRNA and rRNA base modification]
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Statistics
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PSSM-Id: 161659
Aligned: 17 rows
Threshold Bit Score: 335.832
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V9F_A  12 ENQLGQRLDQALAEMFPDYSRSRIKEWILDQRVLVNg-KVCDKPKEKVLGGEQVAi-nAEIe-EEARFEPQDIP----LD 84  Escherichia coli
P44433  20 EDESGQRIDNYLLAKLKGVPKSLIYRIVRKGEVRVNkgRIKPEYKLQTGDVVRIPpvrVAEknDAPISKNLNKVaaleNQ 99  Haemophilus influenza...
P47451   6 VVTTTKRLDSLLASLLN-LSRVKVVKLIMNGQIKVNekLTFKNS-LIVAKDDVIKv-eIHDe-TTSDFITSVEPynlkLE 81  Mycoplasma genitalium...
P47610  11 KESENQRIDQFCLKILPLIKRSDFFKYLRLGKVLLNktKPQVNTRLKTKDEIAFLfdiNPYlqTNNDYLSLDLVkd-kLK 89  Mycoplasma genitalium...
P54604  14 EKQDGQWLFSVLKTALK-ASKPVIQDWMSHQQIKVNheSVLNN--MIVKKGDRVFi-dLQEs-EASSVIPEYGe----LD 84  Bacillus subtilis sub...
Q10786  10 DGLAGMRVDTGLARLLG-LSRTAAAALAEEGAVELN--GVPAGKSDRLVSGALLQv-rLPEapAPLQNTPIDIEg---MT 82  Mycobacterium tubercu...
P72970   1 -------MLDFYSQRYLHSERQAWQERIEQGQIEVDg--KTVDPTYPLQAGQTLTy--WRSpwVEPEVPLQLS------- 62  Synechocystis sp. PCC...
Q12362  94 ERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLN--DEPANLDTIIRDGDLIT---HKV--HRHEPPVTSKP----ID 162 Saccharomyces cerevis...
P75485   6 SVTTAQRLDTFLATLLN-LSRVKVAKLIVDGLVSVNgkKITKNG-WLVQPEDRVHv-nWSEe-LFEKVPVEVQPydfpLD 81  Mycoplasma pneumoniae...
P23851  15 ADEAGQRIDNFLRTQLKGVPKSMIYRILRKGEVRVNkkRIKPEYKLEAGDEVRIPpvrVAEreEEAVSPHLQKVaalaDV 94  Escherichia coli

1V9F_A  85 IVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYYPpia-----dvPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVE 159 Escherichia coli
P44433 100 ILFEDDCLIILNKPSGIAVHGGSGLNFG-VIEALRALRPea--------rFLELVHRLDRDTSGILLIAKKRSALRNLHE 170 Haemophilus influenza...
P47451  82 VLFEDKDLMVINKPSGLLTHPTTFNEKASLLAACIFHNNk---------nPVYLVHRLDRDTSGAIVVCKNQASLLNLQN 152 Mycoplasma genitalium...
P47610  90 IIFEDENIIVVDKPTGIVCQPDKKHSIINLSNMLLKHCGyrqfdsnklnFYPQFAHRIDRNTSGIVIGAKTNKALKELNK 169 Mycoplasma genitalium...
P54604  85 ILFEDNHMLIINKPAGIATHPNEDGQTGTLANLIAYHYQing-----etCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQ 159 Bacillus subtilis sub...
Q10786  83 ILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAGYritt--sgvhERQGIVHRLDVGTSGVMVVAISERAYTVLKR 160 Mycobacterium tubercu...
P72970  63 VLHRDEDLWAIDKPSGLPVLPGGDFVYHTVLEQLKIQYPq---------eSLFPLHRLGTGTSGLLLLGRSTLGRRELSR 133 Synechocystis sp. PCC...
Q12362 163 IVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLG----------YSVHPCNRLDKPTSGLMFLAKTPLGADRMGD 232 Saccharomyces cerevis...
P75485  82 ILYEDEQIMVVNKPNGLISHPTSFNESESLLGAALFHCNh---------qPVFLVHRLDRDTSGVIMLAKNQSSLLHLQK 152 Mycoplasma pneumoniae...
P23851  95 ILYEDDHILVLNKPSGTAVHGGSGLSFG-VIEGLRALRPea--------rFLELVHRLDRDTSGVLLVAKKRSALRSLHE 165 Escherichia coli

1V9F_A 160 SLQRREITREYEAVAIGh-M-TAGGTVDEPISRHPTKRTHMAVHPM----GKPAVTHYRIMEH--FRVHTRLRLRLETGR 231 Escherichia coli
P44433 171 QLRVKTVQKDYLALVRGqwQ-SHIKVIQASLLKNELSSGERIVRVSe--qGKPSETRFSIEER--YINATLVKASPVTGR 245 Haemophilus influenza...
P47451 153 QLQNRTLKRYYVALVHFpfN-ALTGSINAPLARVNNNKVMFKIAQTa--kAKQAITKFKVINQ--NEKAALISLELLTGR 227 Mycoplasma genitalium...
P47610 170 VFKNNHLTKRYKGLVFGqfN---HLGLQTAYWKKDNNNGIVTVKWKpfpeAKKISTFFENSSYiaQKDMSLITIRLISGR 246 Mycoplasma genitalium...
P54604 160 QLEKKTLKRTYTAIAEGklR-TKKGTINSPIGRDRSHPTRRRVSPG----GQTAVTHFKVMASnaKERLSLVELELETGR 234 Bacillus subtilis sub...
Q10786 161 AFKYRTVDKRYHALVQGhpD-PSSGTIDAPIGRHRGHEWKFAITKN----GRHSLTHYDTLEA--FVAASLLDVHLETGR 233 Mycobacterium tubercu...
P72970 134 QFREHICRKIYRTVIGPc-DlPEKFECHQAIGKIPYPQLGYIYAASs--hGKPAQSYGRILAR--SPEKTWLEVEIRTGR 208 Synechocystis sp. PCC...
Q12362 233 QMKAREVTKEYVARVKGefP-IGIVEVDKPVRSVNPKVALNAVCEMsdenAKHAKTVFQRVSY--DGQTSIVKCKPLTGR 309 Saccharomyces cerevis...
P75485 153 QLQQRVMKRYYLALVHFplD-SLSGTISAPLERVGNNKVMWKVGNSsn-kAKNAFTKFTVLNQ--NEKAALIKCELLTGR 228 Mycoplasma pneumoniae...
P23851 166 QLREKGMQKDYLALVRGqwQ-SHVKSVQAPLLKNILQSGERIVRVSq--eGKPSETRFKVEER--YAFATLVRCSPVTGR 240 Escherichia coli

1V9F_A 232 THQIRVHMAHITHPLVGDPVYGGRPRPPKGAseafiSTLRKFDRQALHATMLRLYHPIS--------GIEME-------- 295 Escherichia coli
P44433 246 THQIRVHTQYAGHPIALDDKYGDKDFDKQMN-----ELG--LNRLFLHAFSIRFEHPKN--------GETLR-------- 302 Haemophilus influenza...
P47451 228 THQIRVHLKFIQHPVYNDPLYGIKSE------------KKDSYGQFLHANRICFIHPTL--------NKPMD-------- 279 Mycoplasma genitalium...
P47610 247 THQIRACLNLFSNQLVGDKKYSLIQFK---------NRNNKYKHQALHAYELVFPKLETs------kFPILTn------- 304 Mycoplasma genitalium...
P54604 235 THQIRVHLASLGHPLTGDSLYGGGSK------------LLN--RQALHANKVQAVHPIT--------DELIV-------- 284 Bacillus subtilis sub...
Q10786 234 THQIRVHFAALHHPCCGDLVYGADPKl---------AKRLGLDRQWLHARSLAFAHPAD--------GRRVE-------- 288 Mycobacterium tubercu...
P72970 209 PHQIRIHLASLGYPLLGDRLYGPGGVPINCR-----TARPSDGGYTLHSYQLGFLHLHT--------QQAIK-------- 267 Synechocystis sp. PCC...
Q12362 310 THQIRVHLQYLGFPIANDPIYSNPDIWGPDLg---rGGLQNYDDIVLKLDAIGKTNPAEswihphseGEYLLgrqceece 386 Saccharomyces cerevis...
P75485 229 THQIRVHLQFIKHPVYNDPLYGLKSE------------QATEYGQYLHAQQISFIHPTL--------NKEMG-------- 280 Mycoplasma pneumoniae...
P23851 241 THQIRVHTQYAGHPIAFDDRYGDREFDRQLT-----EAGTGLNRLFLHAAALKFTHPGT--------GEVMR-------- 299 Escherichia coli

1V9F_A 296 ---WHAPIPQDMVELIEVMR 312 Escherichia coli
P44433 303 ---FNASLDHQMKAILQKLR 319 Haemophilus influenzae Rd KW20
P47451 280 ---FHAPLEPKFSTKLKSLN 296 Mycoplasma genitalium G37
P47610 305 --ySLMQFKSKIVPWFEYLI 322 Mycoplasma genitalium G37
P54604 285 ---AEAPFPADMKNLCRTYF 301 Bacillus subtilis subsp. subtilis str. 168
Q10786 289 ---IVSPYPADLQHALKILR 305 Mycobacterium tuberculosis
P72970 268 ---LTAPLPPELITPEVKTI 284 Synechocystis sp. PCC 6803 substr. Kazusa
Q12362 387 aemYTDPGTNDLDLWLHAFR 406 Saccharomyces cerevisiae S288c
P75485 281 ---FEAQLDKTFSDKLDNLN 297 Mycoplasma pneumoniae M129
P23851 300 ---IEAPMDEGLKRCLQKLR 316 Escherichia coli
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