4XHP,4XE7,4XHN,5EC0


Conserved Protein Domain Family
ASKHA_NBD_ParM_Alp7A-like
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cd24023: ASKHA_NBD_ParM_Alp7A-like 
nucleotide-binding domain (NBD) of Bacillus subtilis actin-like protein Alp7A and similar proteins from the ParM domain family
The family corresponds to a group of uncharacterized proteins similar to Bacillus subtilis actin-like protein Alp7A, a plasmid partitioning protein that functions in plasmid segregation. The subfamily also includes Bacillus thuringiensis ParM hybrid fusion protein.
Links
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Statistics
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PSSM-Id: 466873
Aligned: 79 rows
Threshold Bit Score: 157.878
Created: 20-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
nucleotide
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:4XHP; Bacillus thuringiensis ParM hybrid fusion protein in complex with MgADP, contacts at 4A
  • Structure:4XHN; Bacillus thuringiensis ParM in complex with Mg bound AMPPNP, contacts at 4A
  • Structure:5EC0; Bacillus subtilis Alp7A in complex with ADP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #    # #                                                                    
4XHP_A        12 LGGFDTGNiKAKISFLnek-------gnIESFAIPTVIAEAppakidlksapskkndyvnekdeDIELLHVRIISNSldg 84  Bacillus thurin...
5EC0_A         5 RMNVDFGNsMYMNLID------------GYFFELPTNVVEIskeaaegkf-----tsivedpadLKDRLLVSTVIDEt-- 65  Bacillus subtilis
WP_095348590   8 TGGIDVGNsDTKSYLNiltnpknflgnpGSLNTFPSIIAEKspv------------------dvSKNDLILNVIQTPlks 69  Lactococcus lactis
RKW04099       2 KLALDIGNsTVKGTLLddn------nvvVANLQYPSAVTTVsdrky--------------lnytSSDDVYIQVIESEleh 61  Streptococcus sp.
EDL66348      11 FLAVDIGNsWYKVLAStd--------gvVSEYQMPNAIALFddefyemp--------yeeedveIEENLIVEVKSPSvmn 74  Bacillus sp. SG-1
WP_144625392   8 RFNTDAGNsITASIINgn---------vQPVEEIPTAVVQLadnkakd----------yfpdkiSKSELRKSILLKVn-- 66  Bacillus veleze...
WP_081335425   5 RFNKDCGN-SVDMNIMd-----------GYLFDFPTNVVELqkeaadsff-----tdavtapeeFKKRILLSTTIQGee- 66  Achromobacter x...
QCQ57812      11 RFNADFGNsNNNFMVN------------GYYFEMPTNVAPIskqkaetyf-----vdsisepkdLLKKMLISTTIDGe-- 71  Bacillus phage ...
WP_026883178   5 RLNCDFGNsTNNFMVD------------GYYFELPTNVVEIteqranelq-----vnvitdpkeLLERLVVSIERVNe-- 65  Clostridium akagii
CRH66888       5 RFNVDFGNsMYMNLID------------GYYFEIPTNVVELseekaagyf-----tsniddpeeLLERLLISTTIEGe-- 65  Chlamydia trach...

Feature 1                                                                                        
4XHP_A        85 darsRAWYVGayakdqedrqeptvdemgktedkfsQKNKKLHLIPLFTSMAVAAArig--------keEVSVPFSGGMPi 156 Bacillus thurin...
5EC0_A        66 ---eRYFLVGelaepevlg-------nqhikklhnKVESHIPYVTFLAATAYYQAlkgkr----edneVTIEYFQTMLPi 131 Bacillus subtilis
WP_095348590  70 -tlgKLYYVGedaklrssnyh---ktfdiqsknisKVDEDLLSFLVFGSFAQYILkngimdswkgneiEIEAYLGVSLPi 145 Lactococcus lactis
RKW04099      62 --fpVITATGqraiempdyq------efdvtssgyKANNMITTALLFGGIAPYLEd------------HTELKVALSVPi 121 Streptococcus sp.
EDL66348      75 --krEIFYAGksaarqrnv--------sltsvnnqKVDEVRTYILLFSAAAYHALltsen---emdivYEIDQLAVSLPt 141 Bacillus sp. SG-1
WP_144625392  67 ---gQCYLVGdvarrvmgnd------lhingelhsKVKSNIPYIMWLATIAVYDAennqtn--eedteISIDYFSTMLPi 135 Bacillus veleze...
WP_081335425  67 --keRYFLVGdiaasqlla-------nnhinklhnKITSHIPYITFLAAIAYYHAlhakd---kkdntIEIDYFSTMLPi 134 Achromobacter x...
QCQ57812      72 ---eQYFLVGevavpktls-------nvhvkrmhdKIKSPIPYVSFLSAVAYYHAlkgek----dsneIEIDYMSMMLPi 137 Bacillus phage ...
WP_026883178  66 ---kKYYLVGemaelskls-------nshvgnmhdKIKSVIPYVSFLSAIGYYDAikgdg----kgkdIEIEYMSCMLPi 131 Clostridium akagii
CRH66888      66 ---eRFFLVGeiaenevlg-------nnhikklhnKVESHIPLVTFLAATAYYQAikgek----ndneVTIEYFQTMLPi 131 Chlamydia trach...

Feature 1                                                                                        
4XHP_A       157 edyklrg-----eeqilemLYGEHTVEFLdg----tyEGKKIKITINDGTMNvEGVSSVLAIlfdivngeiv-------- 219 Bacillus thurin...
5EC0_A       132 wllkkldkfsemqkrmaskFLGTHQVKVLtl-----gLEKELTIKVEDAACRiESEVARWAIkknfdledk--------- 197 Bacillus subtilis
WP_095348590 146 sdgvnkh-----nqyvdglTRGPHTFVINkg-----eRSLTVNLTVKKAIALaEGEAGVYIFqhptptirkqieelifkt 215 Lactococcus lactis
RKW04099     122 veaktig----lmdlykktLEGKHRILVFrd-----nEVSQVTITITLAVVInEGQAGFFGMfdtidddfrrsldll--- 189 Streptococcus sp.
EDL66348     142 tqykek------keqlkqrLIGSHTVILHkvpgvpepKEVCVKIKINDVIVGaEGACAYLGLtrdqetlgik-------- 207 Bacillus sp. SG-1
WP_144625392 136 felqsaekfsmvkeemaerFIGEHSFEVLtt-----gCEKKITVKVERSKCYeESLVAKYAIqyktnldan--------- 201 Bacillus veleze...
WP_081335425 135 wllkkestfgaaqkamanrFLGDHTFTVHtp-----gFENTLKVVVDESACLkEGESARFALkkdltlkdr--------- 200 Achromobacter x...
QCQ57812     138 wlvkrelkfsvaqnkmsdrFLKEHIVTVHtp-----gMERTLKINVKQAKCRiESEIARHSIkyrmvkkddnakai---- 208 Bacillus phage ...
WP_026883178 132 wllkreqkfsgaqkrmegrFIGEHTVKIMtf-----gMEKELKIIVKNVKCRiESEVARHAIkykmvkgaadknt----- 201 Clostridium akagii
CRH66888     132 wllkklnkfsemqenmatrFAGEHQVKILtf-----gMEKEIKIEVKASKCRvESEVARWAIkknfdledn--------- 197 Chlamydia trach...

Feature 1                             ####                        #    #                         
4XHP_A       220 -----evegmdaeigESYAINDLGAGTSDNAFFEDgelnkKLSTNTDLGT-NKYIDEILKNIKERFMeneilksddtdei 293 Bacillus thurin...
5EC0_A       198 -------dyaeqfknYDVVFCDLGGGTDDLVLLPAglkppKSRDSFVSNT-APFLAHLEKLRKEKLLehfdsvrelekfi 269 Bacillus subtilis
WP_095348590 216 igqndfdpyeeflkyANIQTLDGGGATFDSANFYDk----NGVKFFDPTAsRSLAEGAMTAFNETYYygtqkglqlpdat 291 Lactococcus lactis
RKW04099     190 -yhhlgedsdpisefEDFLIVDIGEGTTDLAVFRNkkfnpDFSYSVTKGY-GNLLEDAIALAARENLtiesrkdlqkllt 267 Streptococcus sp.
EDL66348     208 ------ddglvkdsaKGILIGDLGGDSVDFVGIKNsk-pvASVEGEHFGI-NQFLDIIIQKVSKNELykfdsrseleekl 279 Bacillus sp. SG-1
WP_144625392 202 -------paatkfagFRTILVDLGGGTIDVVLLGTaldkpKKRSDFKTIT-EAPFLGLIKELREGALrsyfksareletf 273 Bacillus veleze...
WP_081335425 201 -------edaneyveCETVMVDIGGGSIDVVILPEglkaaNSRESFQSIE-GIPYLAHIDKLRKEKFlelftdlrafdqf 272 Achromobacter x...
QCQ57812     209 --siekrksaaqfenSKVVLIDIGGGSTDAVCLGVglttpTSRDSFKVID-INPYLGYIEEFRAEKLleefrslrsfenf 285 Bacillus phage ...
WP_026883178 202 --itiekrnnidfadDPIVLADIGGGSTDTVKLGKgltapQSRESFQVID-IEPFLGEIERLRKEKLlenfhdlrglekf 278 Clostridium akagii
CRH66888     198 -------keaeqfknYDVVLVDLGGGTDDLVLLPAglkapKNRDSFDYYT-NVPFLSHLEDLRKSKLieyfeevralekf 269 Chlamydia trach...

Feature 1                                                                                        
4XHP_A       294 espfktredfiqrlvmpevekmieddtykptfsvkwgdvkenvtDIVMDGMLKYAEDQKASLMKFWFkt----naDKNIV 369 Bacillus thurin...
5EC0_A       270 ysnig---------------------ktkmerrdgntgqkfdltDIIKKSLKEYTEIKIAQAENTFPapk--dkvYKYLY 326 Bacillus subtilis
WP_095348590 292 alinl----------------------fnrptdhltsrnkrawsEYWNQARKNLIEKLIDFISEVSSka----nfDLIYA 345 Lactococcus lactis
RKW04099     268 t------------------------------tnkrrqerklkweGYVRPTKAEFIEKVVNTILKTYGtrd---yfDAIIF 314 Streptococcus sp.
EDL66348     280 yagq------------------------sewyvepfagvrkdisKYVIPQLKSMAIKYLELFDRVRSssneikgaSRYIA 335 Bacillus sp. SG-1
WP_144625392 274 ivrnfn--------------------ndsyiwedsktgetvdlsTIIQTALRNYTDEIISIVLNMYPtleq-gerYKYVY 332 Bacillus veleze...
WP_081335425 273 ildnys--------------------kqkfvlknentgesidltSTIKSSLREYVEILLAKLNDVAPppa--nklRKYVY 330 Achromobacter x...
QCQ57812     286 ivknys--------------------kqtyklknentgieidltDKVTEMLSEYAGLLVPQVLNEFIpass-devLKFVY 344 Bacillus phage ...
WP_026883178 279 iirnys--------------------kekyifrdentgkyyeftDQINEVLQEYASVLVTKFLNAFVpen--getIKFVY 336 Clostridium akagii
CRH66888     270 iytnin--------------------ksklerrdgntgktydltDTIKKSLKEYATIKITQSESAFPapk--dsvYKYVY 327 Chlamydia trach...

Feature 1         ###                      ##                                                    
4XHP_A       370 VGGGv---------------------LFGYAGLRDLKe-----------------qDGFILPKNiqe----------saY 401 Bacillus thurin...
5EC0_A       327 FGGVg---------------------EVLEESISVVTeeryg---------rdiseSNHIVAEDa-------------rL 363 Bacillus subtilis
WP_095348590 346 FGGGi--------------------aTLNKDFFGNEDnwlnlavnnklhdiygdnaPFMITVDGei-----------grY 394 Lactococcus lactis
RKW04099     315 VGGGfaaltgyrvdgqgihmdddtlfIELNKELTKLNks----------------vGLLFGIPEey-----------sqG 367 Streptococcus sp.
EDL66348     336 VGGAa---------------------KLAQKQIQEAAvrwse----------kgrpINLYFPEDl-------------eK 371 Bacillus sp. SG-1
WP_144625392 333 FGGVa---------------------PILSKYIIEALqtryt----------envvKEYHHIEPdht----------srF 371 Bacillus veleze...
WP_081335425 331 CGGVa---------------------PTLEVAIMNSMrekig---------eerteKYHKVPEDs-------------rH 367 Achromobacter x...
QCQ57812     345 FGGEa---------------------PILEPYIKENLlkhmn---------eeaanNNHFFLDDiiedkdnevfaptarT 394 Bacillus phage ...
WP_026883178 337 FGGEt---------------------PILKPFIKIALlkhms---------elaaeKNHLFLDEiieddrkeifkpndrT 386 Clostridium akagii
CRH66888     328 IGGVa---------------------PVIEEAIQEVAeeryg---------reiaeTNHIVHPEa-------------rK 364 Chlamydia trach...

Feature 1                
4XHP_A       402 FTSRSYLI 409 Bacillus thuringiensis serovar kurstaki str. YBT-1520
5EC0_A       364 LNLYGLEV 371 Bacillus subtilis
WP_095348590 395 ANTFGLSM 402 Lactococcus lactis
RKW04099     368 INERGLTQ 375 Streptococcus sp.
EDL66348     372 LNVLGLMI 379 Bacillus sp. SG-1
WP_144625392 372 LNLYGLET 379 Bacillus velezensis
WP_081335425 368 LNLFGLEI 375 Achromobacter xylosoxidans
QCQ57812     395 INLNALEL 402 Bacillus phage vB_BtS_B83
WP_026883178 387 INLTALEI 394 Clostridium akagii
CRH66888     365 VNLFGLEI 372 Chlamydia trachomatis

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