Conserved Protein Domain Family
BRINP
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pfam19052: BRINP (this model, PSSM-Id:408822 is obsolete and has been replaced by 465961)
BMP/retinoic acid-inducible neural-specific protein
This entry represents the BMP/retinoic acid-inducible neural-specific protein (BRINP) family, including BRINP1/2/3. They are predominantly and widely expressed in both the central nervous system (CNS) and peripheral nervous system (PNS). They inhibit neuronal cell proliferation by negative regulation of the cell cycle G1/S transition.
Links
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Statistics
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PSSM-Id: 408822
Aligned: 12 rows
Threshold Bit Score: 775.453
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013994799 334 ESEEFQSFVGRLPTHYAVNTSVVEHLWRMDGGLLQRYRQLETTSGLLLDKARRAANKLFSLSKRCRHQPRIVLQRERPLR 413 Atlantic salmon
XP_017334774 441 ESDEFKAFLTRLPQNFYLNASAIHHLWLLDGMFQRRYELLESTMKSLFRRAQRVVYKLFSLSKRCEKQPLIKLPHERPRS 520 channel catfish
XP_017326638 298 QSDEFQAFMVRLSTHAALNLSSVWRAWRSDAALQKRYRKLENDAVFLLNKAQGCAAKLFGLSRRCRSQPKIILPRERRLG 377 channel catfish
XP_018113970 317 ESVEFRSFLKNLPTDRFLNSSAVSKLWNADPALIRRYEQLRTSFKQLVTRSERQMRRLINLSKYCQRQPQYTLLRERSVD 396 African clawed ...
EPQ07113     416 ESEEFQTLLKRLPDDRFLNSTTISQFWAMDAGLQHRYQQLGASLKMLFKKMHRIVSRLFNLCKRCHRQPRFRLPKERSLS 495 Brandt's bat
KFP65193     242 PAEEFQALVKRLPGDRFLNRTAISHFWAMDLDVQHRYQQLGTSLKLLSRKTHRLIRRLFNLSKRCHRQPRFKLPKERSLP 321 Red-legged seriema
XP_014437159 267 krEELQALVRRLPEDRFVNVTTISQYWAMDLDVQHRYQQLGASLKLLLKKTRRIVQRLFNLCRHCHRQPRFRLPKERALP 346 Chinese soft-sh...
XP_006011953 240 EAEELNLFIKKLPTDRFLNSSTISHRWAIDSGLQRRHQQLEASLALLSKKAQRIVRRLFNLCKRCQKQPRFKLPRERSFR 319 coelacanth
XP_029687278 255 ESEEFQNFVGNLPTNHAVNISGVELLWRADANLPQRYRQLETSSNQLFAKARRTANKLFSLSKRCQKQPRIVLQRPRALK 334 torafugu
NP_001107909 314 ESEDFQNFVRRLPTFYALNTSAVQYFWKMDSGVQQRFQLLETNTQQLLSKAQRIVSKLFKLSKRCRTQPKISVPRERPLS 393 zebrafish
XP_015210925 305 DSEEFKMFLARLPQNYFLNISTIHHLWSMDTSFQRRYEQLENSMKGLLKRAQRVVYKIFSLSKRCQKQPQVILPRERPQI 384 spotted gar
XP_006634696 322 NSDEFKSFVKRLPLDHLLNMSTIFQLWSKDMSLQRLYEKLEGSMKHIYSKAQKMIQKLFNLSKRCDKQPQYRLPRERPLT 401 spotted gar

XP_013994799 414 YWLSYILSLLYCSENDHIGLYSVETRSCSCPYHHPPCQGPIPCSVGEGPRCTSCSSENRTRCSSCNPGFTLG-QGLCRPA 492 Atlantic salmon
XP_017334774 521 YWLNYFQSLLYCSENNQMGFFSEELHTCICTYDQYSCQRPTPCSVGEGPACASCASDNYTRCGSCNTGYMLS-QGSCRPM 599 channel catfish
XP_017326638 378 YWLQHSLSLLYCSEAESPGIYSEVTHSCVCPGGHLSCQGLIPCSVGTGSRCASCSPENRTRCSSCNSGFALS-QGLCRPA 456 channel catfish
XP_018113970 397 YWLHRTQSFLYCSATLIPGTFLEASHSCTCTVQHSTCQGPIPCIQGPGPLCSLCSSVHHSQCASCNTGYILTaQGLCTPS 476 African clawed ...
EPQ07113     496 FWWNRIQSFLYCGESTFPGTFLEQSHSCSCPYDQSSCQGPIPCALGEGSACAHCARDNSTRCGGCNPGYVLV-QGLCRPE 574 Brandt's bat
KFP65193     322 YWWSRAQSLLYCSETTVPGTFLEESHSCTCPSDQPSCQGSIPCALGEGPACASCAEDNSTRCGTCNHGYVLT-QGFCRPE 400 Red-legged seriema
XP_014437159 347 YWWSRIQSCLYCSESSPPGTFLEDSHSCTCPSEPASCQGPIPCALGEGPACAACAEENSTRCGACNPGYVLS-QGLCRPE 425 Chinese soft-sh...
XP_006011953 320 YWLTYVQSQLYCSDNSLLGTFHEETHSCTCPYEQTLCQGPVPCVIGEGDACTTCAPDNTTRCGSCNPSYSLV-QGFCRPE 398 coelacanth
XP_029687278 335 FWLNYALSILYCSENNQVGVYSEENHSCSCPYVHPSCQVLIPCSVGDGQRCASCSSENRTRCSSCNPGFTLT-QGICRPA 413 torafugu
NP_001107909 394 YWLRYILSIMYCSENNQIGSYMEETRTCSCHYEHPSCQGVIPCSVGDGPHCASCSYENRSRCASCNPGYMLS-QGTCRNT 472 zebrafish
XP_015210925 385 YWLNHFQSLLYCSENNQLGLFSEETHTCICAYGQNTCQLATPCMLGEGLACATCAADNHTRCGSCNSGYVLS-QGACKHL 463 spotted gar
XP_006634696 402 YWLKKVQSLLYCSENNLSGTFNEELQSCACPMEQDSCQGILPCVVGDGASCSSCAQENPALCGSCNPGYVLI-LGSCRPE 480 spotted gar

XP_013994799 493 VPDPTDPYLGLESDrdLQDLELCYLLQHRDPRITLHGIFVSNDIRLNAWFDPSWRKRMLLTLKSNRYKSNRVHMLLGVAL 572 Atlantic salmon
XP_017334774 600 VADSTDNYLGFETD--LQDLELRYLLQRSDRRLEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSNLVHMLLGISL 677 channel catfish
XP_017326638 457 APSPTKQYLGTEME--MHDLELRDLLEQRDAHLALSAIFVSSDVKLNTWFEPSWRKRMLLTLKSNKSKSSRVHMLLGISA 534 channel catfish
XP_018113970 477 VPESSEPYLGTEGT--LQDLEIKYLLLKRDGRLRAPAFFISGDLRLGVWFQMGGRKRMLLTCKSNKHWPRQLHMLLGLSL 554 African clawed ...
EPQ07113     575 VAESLENFLGLETD--LQDLELKYLLQKWDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 652 Brandt's bat
KFP65193     401 VADSLEHYLGLETD--LQDLELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 478 Red-legged seriema
XP_014437159 426 VADSLEHYLGLETD--LQDLELKYLLQKRDSRLEVHSIFISNDMRLGGWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 503 Chinese soft-sh...
XP_006011953 399 VADSMEQYIGFEGE--LRDLEVKYLLQKRDSRIEVHAIFISNDVRLNSWFDPSWRKRMLLTFKSNKYKTNLVHMMLGLSL 476 coelacanth
XP_029687278 414 VPDPTDPYLGLESDrdLQDLELRYLlQRRDPRIGLHAVFVSNDMRINTWFDPSWRKRMLLTLKSNRVKSNRVHILLGIAL 493 torafugu
NP_001107909 473 IPDSTDNYIGFETD--LQDLELRYLLQKMDGRISIHAMFISNDVRLNNWFDPSWRKRMLLTLKSNKFKSSHVHMLLGISL 550 zebrafish
XP_015210925 464 VADSTENYLGFETD--LQDLELKYLLQKADRRLEVHAIFISNEMRLNSWFDPSWRKRMLLTLKSNKYKSNLVHMFLGISM 541 spotted gar
XP_006634696 481 VSDSPEHYLGLETD--FQDLEMKYLLQKHDSRIEVHAIFISNDMKLNSWFDPSWRKRMLLTLKSNKYRSNLVHMLLGLTV 558 spotted gar

XP_013994799 573 QVCLTKNSSLEPALSMFV-NPFGGSHSESWTMPIGQHGYPDWERTKLDI-PLDCYNWTLTLGNRWKSFFETVHFYLRSRI 650 Atlantic salmon
XP_017334774 678 QICLTKNSTLEPALTLFI-NPFGGSHSESWLIPVNENKFPNWQSTKLDL-PLECFNWTLTLGNKWKTFFETIHIYLRSHI 755 channel catfish
XP_017326638 535 QICMTKNSTLELTLSVSV-NPFGGSHSESWTMPMNQNGYPDWEKTRLDT-PIDCYNWTLTLGNRWKSFFETVHFYLRSRT 612 channel catfish
XP_018113970 555 RLCLAGNGTRDPQVTIYV-NPFGGSHSESWLLPAGEPGYPSWEKTWDTDgGDRCQNWTLILGHRWRSFFETVHFYLRSSP 633 African clawed ...
EPQ07113     653 QICLTKNSTLEPVMAIYV-NPFGGSHSESWFMPVNEAHFPDWERTNVDA-AAQCQNWTITLGNRWKTFFETVHVYLRSRI 730 Brandt's bat
KFP65193     479 QICLTKNSTLEPVMAIYV-NPFGGSHSESWFMPINEGSFPDWERTNVDA-SAQCQNWTLTLGNKWKTFFETVHVYLRSRI 556 Red-legged seriema
XP_014437159 504 QICLTKNSTLEPVMAVYVaP----XHSESWFMPVKEGGFPDWERTNVDA-SAQCQNWTLTLGNKWKTFFETVHVYLRSRI 578 Chinese soft-sh...
XP_006011953 477 QICLTVNSTLEPVLAVYV-NPFGGSHSESWFMPVNEEHFPSWERTNFDL-ALQCSNWTLILGNRWKTFFETVHIYLRSRI 554 coelacanth
XP_029687278 494 QVCLTRNSTLEPALSVFV-NPFGGSHSESWTMPIGQHGYPDWERTKLDL-PLDCYNWTLTLGNRWKSFFETVHFYLRSRT 571 torafugu
NP_001107909 551 QICLTKNSTLEPLLSVYI-NPFGGSHSESWIMPIDQNNYPDWERTKLDI-PLDCYNWTLTLGNKWKTFFETVHIYLRSRV 628 zebrafish
XP_015210925 542 QICLTKNSTLEPVLSLYV-NPFGGSHSESWYVPVNENSFPDWERTKIEL-PLECFNWTLTFGNKWKTFFETIHIYLRGRV 619 spotted gar
XP_006634696 559 QICLTRNSTLEPVLSVYI-NPFGGSHSESWFLPISENHFPDWERTTLDG-FPQCTNWTLTLGNKWKTFFETVHIYLRSRI 636 spotted gar

XP_013994799 651 RDsvpgLAPGPevrghrnaSTVSLESPEGTVEPmvassSQSMGYMKINSMQLFGYSMHFDPDTIQDLILQLDYPYTQGSQ 730 Atlantic salmon
XP_017334774 756 KT----SGPTA--------NESVYLEPLEMADP-----SRNLGYMKINSIQVFGYSMHFNPEAIRDLILQLDYPYTQGSQ 818 channel catfish
XP_017326638 613 QS----DGAQG---------NETVDSEVANRNA-----SQHVGYVKINSIQLFGYIVHFDPEAIRDLILQLDYPYTQGSQ 674 channel catfish
XP_018113970 634 LEd---EEEEE--------DSSEWTKKQTLDDK-----SEDPEYVRIDGLQAFGYSVPFDPEAIRGLAHQLEQP---GSR 694 African clawed ...
EPQ07113     731 KS----LDDSS--------NETIYYEPLEMTDP-----SKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQ 793 Brandt's bat
KFP65193     557 KS----LDDSS--------NETIYYEPLEMADP-----SKNLGYMKINSLQVFGYSLPFEPDAIRDLILQLDYPYTQGSQ 619 Red-legged seriema
XP_014437159 579 KS----LEDSS--------NETVYYEPLEMADP-----SKNLGYMKINSLQVFGFSLPFDPDAIRDLILQLDYPYTQGSQ 641 Chinese soft-sh...
XP_006011953 555 KP----SEVNG--------NESVFYEPLELVDP-----SRNLGYMKINTIQVFGYSMHFDPEGIRDLILQLDFPYTQGSQ 617 coelacanth
XP_029687278 572 RD----FGVASg-------NKTMYYDSVEGAEQ-----SN-IGYMKVNSMQLFGYSVYFDPEAIQDLILQIDYPYTQGSQ 634 torafugu
NP_001107909 629 KT----ASPQG--------NGTVHFEPLEYMDS-----SRNLGYMKINSMQVFGYSMHFDPDAIQDLILQLDYPYTQGSQ 691 zebrafish
XP_015210925 620 KT----QSANS--------SDSIYYEPLEFLDS-----SRNLGYMKINSIRVFGYSMHFDPEAIRDLILQLDYPYTLGSQ 682 spotted gar
XP_006634696 637 KT----TNSNG--------NETTYYEPLELTDP-----SRNLGYLKVNSVRSYGFSMPFDPEAIRDLILQLDYPYTQGSQ 699 spotted gar

XP_013994799 731 DSALLQLVEIRYRVNRLSPPGAQPMDLFSCLLRHRLKLSSSEVTRILASLQAFSVRQPNSVEYEATKLCS 800 Atlantic salmon
XP_017334774 819 DSALMQLQDIRDRVNRLSPPGQQPLDLFSCLLRHRLKLTVNEVMRIHSSLQAFSARLPNPLDYETTKLCS 888 channel catfish
XP_017326638 675 DSALQELMEIRYRVNRLSPAGPTPLDLFSCLLRHRLKLSTSEVSRILAALQAFGAKHRYYTEYEAVKLCS 744 channel catfish
XP_018113970 695 ESAVPEMQELRKRVNFLSPPGIRKLDLFTCLLRHRLKMSSNEVARIQGQLNSFSTQPPNISTYETTKLCS 764 African clawed frog
EPQ07113     794 DSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNAVEYETGKLCS 863 Brandt's bat
KFP65193     620 DSAMLQLLEIRDRVNRLSPPGKTRLDLFTCLLRHRLKLANNEVARIQSSLRAFNTKLPNAVEQEMGKLCS 689 Red-legged seriema
XP_014437159 642 DSALLQLLELRDRVNRLSPPGKTRLDLFSCLLRHRLKLANNEVGRIQSSMQAYSAKLPSPVALTQRERGT 711 Chinese soft-shelled turtle
XP_006011953 618 DSALLQLLEIRDRVNNLSPPGKHRLDLFTCLLRHRLKLSTSEVVRIQASLQAFNAKLPNSVEYETTSLCS 687 coelacanth
XP_029687278 635 DSALLQLVELRYRVNRLSPPGAAHVDLFACLLRHRLKLSGADVTRILAALQAFSARQPNYVEYEANKLCS 704 torafugu
NP_001107909 692 DSALLQLLEIRDRVNRLSPPGQQPLDLFACLLRHRLKLSTTDVVRIQTALQAFSAKQPNSMEYETTKLCS 761 zebrafish
XP_015210925 683 DSALLQLLEIRDRVNKLSPPGQQRLDLFACLLRHRLKLTTTEVVRIHSSLQAFGARLPNSLDYETTKLCS 752 spotted gar
XP_006634696 700 HSALLQLLEIRDRVNMLSRQGKQRLDLFSCLLRHRLKLSASEVVRIRDSLQSFAAKLPHAVDYELAKLCS 769 spotted gar
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