1AJS,7AAT,1YAA,3TAT,1AY4,3BWN,1LK9,1LKC,1IJI,1WST,1C7N,1D2F,1B8G,1BW0,1XI9,2Z1Z,2GB3,2O0R,1YIY,1W7N,3B46,1V2D,1GCK,1J32,1O4S,1GDE


Conserved Protein Domain Family
AAT_like
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cd00609: AAT_like 
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Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
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Statistics
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PSSM-Id: 99734
Aligned: 342 rows
Threshold Bit Score: 93.5599
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1IJI_A; L-Histidinol Phosphate Aminotransferase catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1AJS_A     33 VNLGVGAYrtddcqpwvlpvvrkve---qriannsslnheylpilGLAEFRTCASRLAlgddspa-lqekrvGGVQSLGG 108 pig
AAK73815   31 ADLVIGAYrdqnglpyplkvvrkae----rrivdmgldkeyppmtGLLNFVEEAVKLAygntv----pleriAASQGLSG 102 Trypanosoma brucei
AAK73817   31 VNLGVGAYrdesgkpwilpavkeaea--iissdlskynkeyppvaGFPLFLEAAQFLMfgkdska-aqegriASCQSLSG 107 Giardia intestinalis
3TAT_A     29 VNLSIGLYynedgiipqlqavaeae---arlnaqphgaslylpmeGLNCYRHAIAPLLfgadhpv-lkqqrvATIQTLGG 104 Escherichia coli
NP_284642  29 VNLSIGIYfddegkmpvlesvsrae----taraaapapspylpmeGLDTYRSAVQHLLfgkdnpa-laqgriATVQTLGG 103 Neisseria meningit...
NP_220154  31 INLLLGTYerekkryggfssvrkaq----svffddekdknylpikGSSTFLEEMAALCfgevd-----asrwVGVQAIGG 101 Chlamydia trachoma...
1AY4_A     29 IDLGVGVYkdatghtpimravhaae----qrmletettktyaglsGEPEFQKAMGELIlgdgl----ksettATLATVGG 100 Paracoccus denitri...
AAH29504   30 PNKIFLAYrvcmtneghpwvslvvqktrlqisqdpslnyeylptmGLKSFIQASLALLfgkhsqa-ivenrvGGVHTVGD 108 human
NP_603239  35 INATIGSLynedeklavydvvesvy----rnlppedlyayatnviGEDDYLEEVIKAVffddykealkelhiASIATTGG 110 Fusobacterium nucl...
NP_218663  33 SSSEIVSYaptagipalrerwarr-----lcardpvlcpdepdvaAMQSAAEQGEHSCaavf------pkmsLPIVLPGL 101 Treponema pallidum...

Feature 1                                                                                     
1AJS_A    109 TGALRIGAEFLarwyngtnnkdtPVYVSSPTWENHNGVFTTAgfkDIRSYrywdtekrgldl-----qgflsdlenapeF 183 pig
AAK73815  103 TGSLSLGATLLrqvv----pedtPVYVSNPTWSNHVSIFGIVghkNIREYryyspstheldf-----vgliedlnvapqG 173 Trypanosoma brucei
AAK73817  108 TGSLHIGFEFLhlwm-----pkaEFYMPSTTWPNHYGIYDKVf-nKLKVPykeytylrkdgeleidfsntkkdiqsapeK 181 Giardia intestinalis
3TAT_A    105 SGALKVGADFLkryf-----pesGVWVSDPTWENHVAIFAGAg-fEVSTYpwydeatngvrf-----ndllatlktlpaR 173 Escherichia coli
NP_284642 104 SGALKVGADFLhrwf-----peaRAYVSDPTWDNHCGIFEGAg-fEVGTYpyydpatvgvkf-----demtaffntlpeN 172 Neisseria meningit...
NP_220154 102 TGALHLGASVYanas-----lagKVYIPSQTWGNHSRIFAHQg-lALEYYpyydqetkeldl-----qglkailrsapeT 170 Chlamydia trachoma...
1AY4_A    101 TGALRQALELArman-----pdlRVFVSDPTWPNHVSIMNFMg-lPVQTYryfdaetrgvdf-----egmkadlaaakkG 169 Paracoccus denitri...
AAH29504  109 SGAFQLGVQFLrawh----kdarIVYIISSQKELHGLVFQDMgftVYEYSvwdpkklc-------------mdpdillnV 171 human
NP_603239 111 TGAISNTVKNYmdt-------gdKVLLPNWMWGTYKNIVIENg-gKIETYqlfnengdfnfed----fknkvlelakiqK 178 Fusobacterium nucl...
NP_218663 102 TAALSCAMDLFvga-------gqTVLVPAPRWENYDLMLAVRcaaTPVPFslfragrfdlsa-----ckealdaqasdgV 169 Treponema pallidum...

Feature 1                                                                                     
1AJS_A    184 SIFVLHa---cAHNPTGTDptpeqwkqi-----asvmkrrfLFPFFDSAYQgfasgnlekdaw--airyfvsegfeLFCA 253 pig
AAK73815  174 SIIVLHa---cAHNPTGVDpskdqwati-----advfverkLIPFFDSAYQgfasgsldeday--airhfakrgmeMLLA 243 Trypanosoma brucei
AAK73817  182 SIFLFHa---cAHNPSGIDfteaqwkel-----lpimkekkHIAFFDSAYQgfatgsfeadaf--avrmfvdagveVLVA 251 Giardia intestinalis
3TAT_A    174 SIVLLHp---cCHNPTGADltndqwdav-----ieilkareLIPFLDIAYQgfgagmeeday---airaiasaglpALVS 242 Escherichia coli
NP_284642 173 SVLILHp---cCHNPTGVDmseqqwdev-----lhiiktrkLIPFMDIAYQgfggdldsday---avrkavemelpLFVS 241 Neisseria meningit...
NP_220154 171 SLVLLHc---cCHNPTGKDiplsewpei-----itiikerdLIPFFDMAYLgfasgieedrr---pvrlcieagvtTFVA 239 Chlamydia trachoma...
1AY4_A    170 DMVLLHg---cCHNPTGANltldqwaei-----asilektgALPLIDLAYQgfgdgleedaa---gtrliasripeVLIA 238 Paracoccus denitri...
AAH29504  172 VEQIPHgcvlvMGNIIDCKltpsgwakl-----msmikskqIFPFFDIPCQglytsgleedtr--ilqyfvsqgfeFFCS 244 human
NP_603239 179 NVVLILne--pSHNPTGFRmtyeewvnll--dffksikdtnIIVIRDVAYFeyddrgeeetkklrklligmpknilFMYA 254 Fusobacterium nucl...
NP_218663 170 IRLILNf----PHNPSGYTpteeeaqqlyevvyayadagcaVLVICDDAYSgfeyeaslmrgsffarfaqahknicALKI 245 Treponema pallidum...

Feature 1         #                                                                           
1AJS_A    254 QSFSKNfglyNERVGNLTVVakepd--------silrVLSQMQKIvrvtwsnpPAQGARIVARTLsdpelfh---ewtgn 322 pig
AAK73815  244 QSFSKNmglyAERVGVISAVvsdas--------rkeaVRSRLEVIarsyystpPVHGARIAHLVMsdkelra---eweqe 312 Trypanosoma brucei
AAK73817  252 QSFSKNfglyGERIGCLHVVhagvegsveknkalsaaMVSGMTLQirktwsmsAIHGAYIVQVIVhdkrllq---mfydn 328 Giardia intestinalis
3TAT_A    243 NSFSKIfslyGERVGGLSVMcedae--------aagrVLGQLKATvrrnysspPNFGAQVVAAVLndealka---swlae 311 Escherichia coli
NP_284642 242 NSFSKNlslyGERVGGLSVVcpnke--------eadlVFGQLKFTvrriysspPAHGAYIAADVMnspelya---lwqne 310 Neisseria meningit...
NP_220154 240 GGASKIfslyGSRVGFFGAIhqdkl--------dlnrILSFLEEQirgeysspAREGVAIVTSILsnpylrq---ewele 308 Chlamydia trachoma...
1AY4_A    239 ASCSKNfgiyRERTGCLLALcadaa--------trelAQGAMAFLnrqtysfpPFHGAKIVSTVLttpelra---dwmae 307 Paracoccus denitri...
AAH29504  245 QSLSKNfgiyDEGVGMLVVVavnnq--------qllcVLSQLEGLaqalwlnpPNTGARVITSILcnpallg---ewkqs 313 human
NP_603239 255 FSLSKSlsiyGMRIGAQIAVssdee--------viqeFKDALPFScrttwsniPKGGMKLFATIMknpelk----anflk 322 Fusobacterium nucl...
NP_218663 246 DGLTKEeyawGLRVGFLSCAglalgv------sqyqaFEKKVMGMiraslsctATLTQTLALRLLaeedepaglgsatar 319 Treponema pallidum...

Feature 1                                                                                     
1AJS_A    323 vKTMADRILSMRSELRARLEalktpgtw----------nhitdqigMFSFTGln--------pkQVEYLINqkHIYLLPs 384 pig
AAK73815  313 lKEMVNRVRSMRQGVYEGLMklgtpgtw----------ehiinqkgMFSYMGls--------rpQCERLCEk-RVFVLPv 373 Trypanosoma brucei
AAK73817  329 vKEMSARIHRMRSLLHASLAkrktpgpgskg-----twdhiltaigMFTFTGlt--------peHVDYLKEkwSIYLVKa 395 Giardia intestinalis
3TAT_A    312 vEEMRTRILAMRQELVKVLStempernf----------dyllnqrgMFSYTGls--------aaQVDRLREefGVYLIAs 373 Escherichia coli
NP_284642 311 vYMMRDRIRAMRQKLYDVLTaqipdrdf----------tyfikqrgMFGYTGls--------veQVRRLRDefAVYLLDs 372 Neisseria meningit...
NP_220154 309 lNGIRQSLEEIRSSFVIAMRnvaghsfd-----------fiasqkgFFGYPGfs--------keQVLFLREelGIYTTAg 369 Chlamydia trachoma...
1AY4_A    308 lEAVRSGMLRLREQLAGELRdlsgsdrf----------gfvaehrgMFSRLGat--------peQVKRIKEefGIYMVGd 369 Paracoccus denitri...
AAH29504  314 lKEVVENIMLTKEKVKEKLQllgtpgsw----------ghiteqsgTHGYLGln--------sqQVEYLVRkkHIYIPKn 375 human
NP_603239 323 eKQGYMNLLNERANIFLKEAkeenlkv-------------lpyksgFFVTVPvget-----vdkIIEDLESk-NIFVIKf 383 Fusobacterium nucl...
NP_218663 320 eRHQFFQLMCARYREVQRVVrdltwsttecgaavplrveflpcnsgYFTCIRcigfsaetlrqyLLEQCGIg-TVAIDEq 398 Treponema pallidum...

Feature 1                              
1AJS_A    385 ---GRINMCglttKNLDYVATSIHE 406 pig
AAK73815  374 ---GRANLAaltpSTMDFLVKSIDD 395 Trypanosoma brucei
AAK73817  396 --gGRMSMCglteSNCDYVAEAIHD 418 Giardia intestinalis
3TAT_A    374 ---GRMCVAglntANVQRVAKAFAA 395 Escherichia coli
NP_284642 373 ---GRMCVAglntSNTDYVARAFAE 394 Neisseria meningitidis Z2491
NP_220154 370 ---GRFNLNgitdKNINRVTHGFAQ 391 Chlamydia trachomatis D/UW-3/CX
1AY4_A    370 ---SRINIAglndNTIPILARAIIE 391 Paracoccus denitrificans
AAH29504  376 ---GQINFScinaNNINYITEGINE 397 human
NP_603239 384 dtgIRIGLCsvpkRKIKGLAKKIKD 408 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
NP_218663 399 --hLRVAFSalelPAIERVLRAVVH 421 Treponema pallidum subsp. pallidum str. Nichols

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