1LMB,1ADR,1B0N,1ZUG,2OR1


Conserved Protein Domain Family
HTH_XRE

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cd00093: HTH_XRE 
Click on image for an interactive view with Cn3D
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
Statistics
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PSSM-Id: 238045
Aligned: 557 rows
Threshold Bit Score: 31.7546
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:non-specific DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:non-specific interactions with DNA backbone, mostly by positively charged sidechains.
  • Citation:PMID 1387915
  • Structure:1LMB_4 interacts with DNA backbone

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   #                            #                           
1LMB_4     15 ARRLKAIYEkkknelgLSQESVADKMGMGqSGVGALFNGin-aLNAYNAALLAKILk--VSVEEF 76   bacteriophage lambda
93717      27 GTRIAEVARl-----lDSRRALAKQVGIHeTQLYRYIKGin-aAAPELLSAIAKAGr--VSLDWL 83   Bacteriophage D3112
4455040    19 AARLRKLREqa---gsPTYRDLARDAHYSiASLSSAAAGrq-lPSLAVTLAYVRVCg--GDEREW 77   Streptomyces lincolnensis
5823635     4 INNLKKIRIak----gITQLEAAEAIGISySLLSKMEAGyrgsSDKTKIKVANFYGk-sVGEIFF 63   Bacteriophage A118
7379958    29 ALNLVEERSrl----gYSRKNFAEQTGCSaESLRLYESGqv-nIPADFLLAAVQLG---VDIQFV 85   Neisseria meningitidis Z2491
7515533    15 VEALRRARSr-----gVTYRELAEATGVDeTLLARYVSGrv-mPGARQAERIWKGL---LDILGP 70   Aeropyrum pernix
7521592    14 IRMLRILKKt------YTYEDLSKITGLPiTVLNRYVKGkv-lPSVERAKELEEQL---GKYLDL 68   Pyrococcus abyssi
NP_354820  13 GRRLRAVRAaf---diDDRDVFASRLVISkSGLAHYERGer-vPDAELLSAYHREFg--VNISWL 71   Agrobacterium tumefaciens str. C...
NP_461316  10 RADIKSALEkr----gITLRDLSRQAGLSpDSLRNVFTRs---WPRAERIIADALG---ITPKEI 64   Salmonella typhimurium LT2
NP_559743  14 VGYLKSVKAll----gITYKELAAVLGIPeSVLSRYATGdm-lPSVETAREMLEKLearYHISSV 73   Pyrobaculum aerophilum

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