Conserved Protein Domain Family
BEX
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pfam04538: BEX (this model, PSSM-Id:398300 is obsolete and has been replaced by 461346)
Brain expressed X-linked like family
This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.
Links
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Statistics
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PSSM-Id: 398300
Aligned: 64 rows
Threshold Bit Score: 59.5741
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001503090   1 MERVDKENEGKPE-NQGNSENEG-KPEDevdtedegksdeegkpavegqpghqgkpqnegqpddeaqpedegkqdkqgks 78  horse
XP_003802562  14 MDNTNQENEEKa--EKEQDANKG-EP-Lah-------------------------------------------------- 39  small-eared galago
Q9BXY8        14 VENVNQENDEKd--EKEQVANKG-EP-Lal-------------------------------------------------- 39  human
ELK17708       1 MEKANQENRKKKKdEKGQDANKG-EP-Lg--------------------------------------------------- 27  black flying fox
XP_003435428  14 MENTDQENKKYd--EKEQSTNKG-EP-Lal-------------------------------------------------- 39  dog
XP_006082363  14 VENANQENEIKd--EKEQDANKG-EP------------------------------------------------------ 36  little brown bat
XP_012668634  14 MENAQKKHEGKe--EKDQVANKGeEP-Lal-------------------------------------------------- 40  small-eared galago
XP_006163610  14 VENGNKEDEGKd--EKEQDANKG-EP-Mgr-------------------------------------------------- 39  Chinese tree shrew
XP_006166113  14 MENAQKANE-----EQEQVANKG-EP-Vtl-------------------------------------------------- 36  Chinese tree shrew
XP_008508744  14 MKNTNQENEKK-D-EKEQDANKG-EHLAl--------------------------------------------------- 39  Przewalski's horse

XP_001503090  79 edegkpqggegkresqakpeserraaekrpAEDYVPRKAKRKTDRG-TDDSPKDYQEDLQERHLGSEEMMREcGDMSRAQ 157 horse
XP_003802562  40 -----------------------------pL---EYSVPRGNRRRFrVRQPILQYRWEVMHRLGEPQARMRE-ENMERIG 86  small-eared galago
Q9BXY8        40 -----------------------------pLNVSEYCVPRGNRRRFrVRQPILQYRWDIMHRLGEPQARMRE-ENMERIG 89  human
ELK17708      28 -----------------------------iKEAGGYYVPRGNSRQFpVRHPILQYRWDVIQRFGEPQARMRE-ENMERIG 77  black flying fox
XP_003435428  40 -----------------------------pLETGEYCVPRVNRRRFrVRQPILQYRWDVFQRLEEPQGRMRE-ENMEKIG 89  dog
XP_006082363  37 ---------------------------------GEYCVPRGNRRRFrVRQPVLQYRWDGGQRLGEPQARMRQ-ENRERVG 82  little brown bat
XP_012668634  41 -----------------------------pLETGEYCVPRGNRRRFrARQPILQYRWDMMHRLGEPQARMRE-DNMERIG 90  small-eared galago
XP_006163610  40 -----------------------------pLEAGEHCVPRGNRRRFrVRQPVLQYRWDTLHRLGVPQARMRK-ENMERFG 89  Chinese tree shrew
XP_006166113  37 -----------------------------pLEAREHCVPRGNRRRFrVRQPILQYRWDLMHRLGEPQARMRE-ENMGRFG 86  Chinese tree shrew
XP_008508744  40 -----------------------------pLETGECGVPRGNRGQIhVRQSILQYRWDMIQRLEEPQARMRE-ENMERIG 89  Przewalski's horse

XP_001503090 158 EELRKK-QKMGGFHWMQ--------RDVQDPFAPR 183 horse
XP_003802562  87 EEMRQLmEKLREKQLSHslravstdPPHHDHRDEF 121 small-eared galago
Q9BXY8        90 EEVRQLmEKLREKQLSHslravstdPPHHDHHDEF 124 human
ELK17708      78 EQMRQLmRKLRVKQLSHslpavstdLCHHDHHNKF 112 black flying fox
XP_003435428  90 EEMRQLmQKLKEKQFSHslqavstdPPHRDHQDEF 124 dog
XP_006082363  83 EEMRQLmEKLRGKQLSHslravstdPPHHDHHDEF 117 little brown bat
XP_012668634  91 EEVRQLmEKLREKQLSHslqavstdPPHHDHHDEF 125 small-eared galago
XP_006163610  90 EEVRHLmEKLREKQLSHslqavsldPPHHGHRDEF 124 Chinese tree shrew
XP_006166113  87 EEVRHLmEKLREKQLSHslravsldPPHHGHRDEF 121 Chinese tree shrew
XP_008508744  90 EEVRQLrEKQLSHSLRAvs----tdPPHHDHHDEF 120 Przewalski's horse
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