6DFT


Conserved Protein Domain Family
DS
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pfam01916: DS (this model, PSSM-Id:396479 is obsolete and has been replaced by 460382)
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Deoxyhypusine synthase
Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.
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Statistics
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PSSM-Id: 396479
Aligned: 221 rows
Threshold Bit Score: 232.294
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6DFT_F                31 VLNAYPNI-GLEATNLGRARRIVQRAlndNGMDGNKVMLAYTSNLISSGLRDTFACLARENRIGAVVTTAGGVEEDVIKC 109 Trypano...
WP_012939763          17 lIKELYKSgGFTAKDLAVAVDIFEEM---IKDEECTVFLSFPACIIATGTRGVIKELVKRRLVDVIVTTCGTLDHDLARI 93  Archaeo...
jgi:Aboo_0041         23 lmDELYSSgGFVAKHLAVAEKILLKM---FK-EENTTFLSFPACIIATGTRGVIKEIVRRKLVDVIITTCGMLDHDIARS 98  Aciduli...
Q6KZL5                25 LIGMFGRSgGFTAKKIYEGYEIIKEM---FN-DDETTFLSFPADIISTGTRGIINELVKRKLVDVIITTNGTLDHDIART 100 Picroph...
Q9HL74                25 LMDQFSSIgGFTAAKIHEAYEIIKDM---FS-EDNTTFLSFPADIISTGLRGLINEVVKRKLVDVIITTSGTLDHDIART 100 Thermop...
EQB66656              27 fvsqcnASgGFTSSKIAVAHSIMEKI---VK-EENTTFLSFPADIISTGTRGVIIDMIKKGLVDVIITTTGTIDHDIARS 102 Thermop...
EQB69201              27 lISQFLESgGFTSSKIGVAYEILKEM---VE-EENTTFLSFPADIISTGTRGIINEMVKRKMVDVIITTCGTLDHDIARS 102 Thermop...
Q74MF0                18 LIKQFSSIgGFQAQELYRGYEILKEM---FD-NAEYKILSFPADIIATGIRGIIKELIKRKMFDLVITTCGTLDHDLARL 93  Nanoarc...
jgi:Nmar_0648         22 ifqELSQSgGFESVNLSTGVDILSEM---ISDKQCLKFISFVGAVVSTGLRGILKDMLKNKWFDVAITTCGALDHDIARH 98  Nitroso...
goetting:Ngar_c06230  30 ifssMTRSgGFESRNLADGVDILRRM---IDDKSCTKFMSFVGALMSTGARGIIRDMVRNKMCDVIITTCGALDHDIARA 106 Candida...

6DFT_F               110 LgD-TLVGDFALNDHALRNNGLNRVGNLLVPNDNY-RNFEDFFVPLLRRLHE-QQrDsRWttktTPSQIIAEIGAALEsv 186 Trypano...
WP_012939763          94 W-KdYYHGSFMLDDVELYKKGIHRIGNVLTPKESYgLILEEKLQPIFEDIYNeGK-R-RI----STRELIWEVGKRIEge 166 Archaeo...
jgi:Aboo_0041         99 F-KnYYHGSFLMDDTALHREGVNRLGNVLVPNESYgVVMENFMMPILEELYK-EK-K-EW----GGRELIDEFAKRMn-- 168 Aciduli...
Q6KZL5               101 Y-RdYYAGTFNFSDAMLRDLGINRLGNVFVPDESYgSIIEEKVMPILDELYK-EK-K-EW----SGYELIWELGKRIn-- 170 Picroph...
Q9HL74               101 Y-RnYYCGSFSYSDIELRDLGINRLGNVLVPDESYgEIIEEKVMESLEKLYA-KK-K-EW----ATVDLIHEVGLDIn-- 170 Thermop...
EQB66656             103 F-SdYFCGSFEYDDIKLKDMGINRLGSVFVPDESYgSLIEEFMMKQLDTLYK-EK-K-TW----SPSEILARIGRNMd-- 172 Thermop...
EQB69201             103 F-RdYYCGSFDYNDRELKDLGINRLGSVVIPDESYgEIMEEFMQKELEKLYK-ES-K-KW----TTWKLIEKIGLAIk-- 172 Thermop...
Q74MF0                94 E-KdYYLGYFEADDIELREKNIFRLGNIFIPEENYgLAIENILKKALPYIYN-KK-K-EL----STYEFVWLLGEYLEnh 165 Nanoarc...
jgi:Nmar_0648         99 F-ShYKEGSFTMDDNELADQDIHRLGNVLVPMDSYgPLIEEKMQTFLEEEYQnGV-K-EM----TTAEICKMIGKHL--- 168 Nitroso...
goetting:Ngar_c06230 107 Y-DkYYAGDFRMDDGMLLDKDIHRLGNVLVPMGNYgPLIEEKIQKCLADMYKeGK-R-SV----STYEITDYIGSTL--- 176 Candida...

6DFT_F               187 rpndCGSSLIYWCYRNDIPVFSPAFTDGSMGD-MIYFYNySRKgLVVDPVPDVRRLRQLGCKStnvGRITCIVLGAGLPK 265 Trypano...
WP_012939763         167 --enADSSIVYWCYKNKIPVFVPGITDGAFGSqLWLFYQ-THKdFIVDVLKDEDELSEIIFNA---KRSGALIVGGGISK 240 Archaeo...
jgi:Aboo_0041        169 ----NEDSILYWAHKNKIPIYVPGITDGSFGSqLWSFRE-MHPdFRVDVLKDEHELADIIFDA---KKTGALMIGGGISK 240 Aciduli...
Q6KZL5               171 ----NESSIIYNAYKNRIPVFIPGMTDGSVGSqLWSFYE-MNRdFRINLLEDEHKLSDIIFDA---KKTGAIMIGGGISK 242 Picroph...
Q9HL74               171 ----SESSIIYNAAKNNIPVFVPGITDGSFGSqLWSFYE-QHHdFKINLLEDEHRLSDIIFDA---KKTGAIMIGGGISK 242 Thermop...
EQB66656             173 ----HPDSILSAAAEKNVPIFIPGIPDGSVGSqFWSFYE-THRdFNLDILMDQHLISDIVFTS---DRAGAIMIGGGISK 244 Thermop...
EQB69201             173 ----NDDSILYNAAKNHIPIFVPGITDGSFGSqLWSFKE-MNSdFIVDVLQDEHDLSDIIFDA---KKTGALMIGGGISK 244 Thermop...
Q74MF0               166 --pkKEESIIYWAYKNRIPIIIPGITDGAVGTqILLFRQ-EHRdFNVNVWLDEEFLLNQFFGD---KNIGALMLGGGISK 239 Nanoarc...
jgi:Nmar_0648        169 ----GEDSFLYWAYKNHISVVVPGIMDGAVGSqIWLFTQ-KHNdFKLNMAGDADLLSGYIFKA---EKSGAFMIGGGISK 240 Nitroso...
goetting:Ngar_c06230 177 ----DKSSFLYWAHKNRIPVIVPGIVDGAVGSqVWFFYQ-QHKdFKVDILKDQSKLSDIVFEA---KRSGAFMIGGGISK 248 Candida...

6DFT_F               266 HHLL-----RNvQADAVVYVTTGSDADGCESSCNVMADRANGLLSPNCDVVRVHGDATIISPLLLL 326 Trypanosoma brucei
WP_012939763         241 HHTIwwnqfKD-GLDYVVYITTAVEWDGSLSGARVREAISWGKVSESAKSVNVYGDATVLLPLIVA 305 Archaeoglobus profundus
jgi:Aboo_0041        241 HHTIwwnqfRD-GLDYAVYITTAVEWDGSLSGARVREAVSWGKVREDAKYVTVEGDATVLLPLLIT 305 Aciduliprofundum boon...
Q6KZL5               243 HHTIwwnqfRD-GLNQAVYITTAQEYDGSLSGAKLEEAISWKKVREDARFVNIYGDATVILPLIVA 307 Picrophilus torridus ...
Q9HL74               243 HHTIwwnqfRD-GLDYAVYVTTAQEYDGSLSGAKLEEAISWKKVRPDARYVNVYGDATVIMPVLLA 307 Thermoplasma acidophi...
EQB66656             245 HHTIwwnqfRG-GLDYAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAEFVNVYGDATVLLPIIVA 309 Thermoplasmatales arc...
EQB69201             245 HHTIwwnqfRG-GLDSAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAKFVNVYGDITALLPLLVg 309 Thermoplasmatales arc...
Q74MF0               240 HHTIwwaqfSN-GLKYAVYVTSAVELDGSLSGARTREAISWGKIDKKAKHVTIWGDVTIILPLLVg 304 Nanoarchaeum equitans
jgi:Nmar_0648        241 HHTLwwnqyRE-GLDYAFYITTAQEFDGSLSGALVREAISWGKVTQKAKQSTLHAEVTTILPFIYA 305 Nitrosopumilus mariti...
goetting:Ngar_c06230 249 HHTLwwnqfRG-GLDYAVYITTAPEWDGSLSGALVAEAISWGKVTAKARQVTIHGEATTLLPFIYA 313 Candidatus Nitrososph...
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