Conserved Protein Domain Family
pcna

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TIGR00590: pcna 
proliferating cell nuclear antigen (pcna)
All proteins in this family for which functions are known form sliding DNA clamps that are used in DNA replication processes. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273158
Aligned: 9 rows
Threshold Bit Score: 346.274
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O02115   1 MFEAKLANAGLLKKIVESIKDLVTDAPFDCSETAMSLQAMDSSHVALVSLKLEVGLFDTYRCDRTINLGLSLANMSKALK 80  Caenorhabditis elegans
P15873   1 MLEAKFEEASLFKRIIDGFKDCVQLVNFQCKEDGIIAQAVDDSRVLLVSLEIGVEAFQEYRCDHPVTLGMDLTSLSKILR 80  Saccharomyces cerevis...
P17918   1 MFEARLIQGSILKKVLEALKDLINEACWDVSSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK 80  house mouse
P53358   1 MFEARLIQGSNLKKVQEALKDIVTEASWDCTSSGISLQAMDSSHVSLVQLTLRADGFENFRCDRNLAMGINMTSMAKIMK 80  Styela clava
P17917   1 MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILK 80  fruit fly
Q43266   1 MLELRLVQGSLLKKVLEAIRELVNDANFDCSGTGFSLQAMDSSHVALVALLLRAEGFEHYRCDRNLSMGMNLNNMAKMLR 80  Zea mays
Q03392   1 MLEARFQQAALLKKLLDAIKELVTDANFDCNDNGISLQAMDSSHVALVSMLIKSDGFEPYRCDRNIALGINLNALSKVLR 80  Schizosaccharomyces p...
P11038   1 MFEAEFKTGAVLKRLVETFKDLLPHATFDCDNRGVSMQVMDTSHVALVSLQLHAEGFKKYRCDRNVPLNVSINSLSKIVK 80  Autographa californic...
P31008   1 MLEAKLNNASILKKLFECIKDLVNDANVDADESGLKLQALDGNHVSLVSLHLLDSGFSHYRCDRERVLGVNIASLNKVFK 80  Plasmodium falciparum K1
O02115  81 CANNDDTCMLkYEENEGDSIIFTFADPKRDKTQDVTVKMMDIDSEHLGIPDQD--YAVVCEMPAGEFQKTCKDLSTFSDS 158 Caenorhabditis elegans
P15873  81 CGNNTDTLTL-IADNTPDSIILLFEDTKKDRIAEYSLKLMDIDADFLKIEELQ--YDSTLSLPSSEFSKIVRDLSQLSDS 157 Saccharomyces cerevis...
P17918  81 CAGNEDIITL-RAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQE--YSCVIKMPSGEFARICRDLSHIGDA 157 house mouse
P53358  81 CAGNDDIITL-RAEDNADMLELIFESSKGDKYSQYEMKLMDLDCEQLGIPEQD--YSCCVTLPSQEFGRICRDLSQIGEC 157 Styela clava
P17917  81 CANNEDNVTM-KAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETD--FSCVVRMPAMEFARICRDLAQFSES 157 fruit fly
Q43266  81 CAGNDDIITI-KADDGSDTVTFMFESPKQDKIADFEMKLMDIDSEHLGIPDSE--YQAIVRMPSSEFMRICKDLSSIGDT 157 Zea mays
Q03392  81 CAQNEDLVTL-KAEDTPEVLNLVFESEKNDRISDYDVKLMDIDQEHLGIPDIE--YDATITMPAAEFQRITRDLLTLSDS 157 Schizosaccharomyces p...
P11038  81 CVN-ERSSVLmKAEDQGDVMAFVFN--NDNRICTYTLKLMCIDVEHLGIPDSD--YDCVVHMSSVEFAQVCKDMTQFDHD 155 Autographa californic...
P31008  81 LCGANESVVI-SSKDDEDNLNFVFENNKEDKVTNFSLKLMSIELDSLNIPDCEegFDAEVELSSKELTNIFRNLSEFSDT 159 Plasmodium falciparum K1
O02115 159 LNITATKAGIVFTGKGDIGSSVVTYSPSSNTD-DETEAVTLEVKDPVNVNFSIKYMNQFTKATALSDRVRLSLCNDVPVV 237 Caenorhabditis elegans
P15873 158 INIMITKETIKFVADGDIGSGSVIIKPFVDME-HPETSIKLEMDQPVDLTFGAKYLLDIIKGSSLSDRVGIRLSSEAPAL 236 Saccharomyces cerevis...
P17918 158 VVISCAKNGVKFSASGELGNGNIKLSQTSNVD-KEEEAVTIEMNEPVHLTFALRYLNFFTKATPLSPTVTLSMSADVPLV 236 house mouse
P53358 158 VVITCTKDGVQFSAKGDLGAGKIKLKQNTGSDiKEEEQVTVEISEPVQLTFAIKYLNLFAKASPLSPSVCLSMSNNVPLV 237 Styela clava
P17917 158 VVICCTKEGVKFSASGDVGTANIKLAQTGSVD-KEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLV 236 fruit fly
Q43266 158 VVISVTKEGVKFSTSGEIGSANIVCRQNQTID-KPEEATIIEMQEPVSLTFALRYMNSFTKASSLSEQVTISLSSELPVV 236 Zea mays
Q03392 158 VTINASKEGVRFSCKGDIGNGSTTLKQHTDLS-DQDQSIEISLTQAVTLTFSLKYLAQFTKATPLATRVTLSMSNDVPLL 236 Schizosaccharomyces p...
P11038 156 IIVSCSKKGLQFRANGDIGSADVQMSADNENF------SVLKAKQTVTHTFAGDYLCHFAKAAPLAPTVTIYMSEELPFK 229 Autographa californic...
P31008 160 VFIEIDSNCIKFTTKGIVGDAEVALKPRDSTS-EDDIGVTIKSKKKIKQSFAIKYLNLFSKSNILADVVVLGLSDSRPIE 238 Plasmodium falciparum K1
O02115 238 VEYPIEEn---------GYLRFYLAPKIDDDE 260 Caenorhabditis elegans
P15873 237 FQFDLKS----------GFLQFFLAPKFNDEE 258 Saccharomyces cerevisiae S288c
P17918 237 VEYKIADm---------GHLKYYLAPKIEDEE 259 house mouse
P53358 238 VEYKVADm---------GHIKYFLAPKIEDEE 260 Styela clava
P17917 237 VEYAIKDl---------GHIRYYLAPKIEDNE 259 fruit fly
Q43266 237 VEYKIAEm---------GYIRFYLAPKIEDDE 259 Zea mays
Q03392 237 VEYK-MEs---------GFLRFYLAPKIGEED 258 Schizosaccharomyces pombe 972h-
P11038 230 LEYCIKDv---------GVLACFLAPKIVNND 252 Autographa californica nucleopolyhedrovirus
P31008 239 FKYEIKDtspdsdtlkiGFVKFFLAPKMDDDM 270 Plasmodium falciparum K1
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