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Frog skin active peptide family signal and propeptide This family contains a number of defence peptides secreted from the skin of amphibians, including the opiate-like dermorphins and deltorphins, and the antimicrobial dermoseptins and temporins. The alignment for this family consists of the signal peptide and propeptide regions and does not include the active peptides.Family members such as the peptide leucine arginine (pLR) belongs to a class of cyclic peptides isolated from frog skin. Its primary sequence is similar to the reactive loop of plant Bowman-Birk inhibitors (BBI), and the circular sunflower trypsin inhibitor-1 (SFTI-1) and to HV-BBI, an isolated peptide from amphibian skin with trypsin-inhibitory activity. pLR is a highly potent trypsin inhibitor, with therapeutic potential. A study describing immunomodulatory properties of pLR showed that the peptide is a potent activator of histamine release. Other members such as Phylloseptins are antimicrobial peptides of 19-20 residues and carry an amidated C-terminus. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",