Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains
This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Feature 1:ATP binding site [chemical binding site]
Evidence:
Comment:based on structures of the HATPase domain of human Hsp90, Escherichia coli DNA gyrase B, and other related proteins, bound with ATP, ADP or their analogs; contacts at 4A
Jiyao W et al.(2023). "The conserved domain database in 2023.",