Conserved Protein Domain Family
bHLH_dnHLH_ID1
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cd19691: bHLH_dnHLH_ID1 
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins
ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.
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Statistics
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PSSM-Id: 381534
Aligned: 6 rows
Threshold Bit Score: 96.4091
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:HLH region of bHLH forms homo- and heterodimers
  • Comment:Based on the structure evidence that Homo sapiens ID-2 (4AYA) forms a homodimer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  ##  ## ##  #            ##  ## ## ### ##  #   #
P41134        62 VNVLLYDMNGCYSRLKELVPTLp-qNRKVSKVEILQHVIDYIRDLQLELNSES 113 human
AFK11302      44 MSMFLYDMNSCYSKLKELVPTLp-qNKKVSKVEILQHVIDYIWDLQVELDTHP 95  elephant shark
XP_006009385  41 INVFLYDMNGCYSKLKELVPTLp-qNKKVSKVEILQHVIDYISDLQLELDTQP 92  coelacanth
AAB62940      43 MTMFLQDMNSCYSKLKELVPTLp-tNKKASKMEILQHVIDYIWDLQVELESKK 94  zebrafish
NP_989921     43 AAALLYDMKGCYSRLRALVPTLp-rHRRVSKVELLQHVIDYIWDLQLALQPGP 94  chicken
ABW74716      26 EERLLYDMKGCYSRLSQLVPTLantGRKASRMEILQHVIDYILDLQVALDEGP 78  sea lamprey

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