4PGM


Conserved Protein Domain Family
pgm_1
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TIGR01258: pgm_1 
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phosphoglycerate mutase, BPG-dependent, family 1
Most members of this family are phosphoglycerate mutase (EC 5.4.2.1). This enzyme interconverts 2-phosphoglycerate and 3-phosphoglycerate. The enzyme is transiently phosphorylated on an active site histidine by 2,3-diphosphoglyerate, which is both substrate and product. Some members of this family have are phosphoglycerate mutase as a minor activity and act primarily as a bisphoglycerate mutase, interconverting 2,3-diphosphoglycerate and 1,3-diphosphoglycerate (EC 5.4.2.4). This model is designated as a subfamily for this reason. The second and third paralogs in S. cerevisiae are somewhat divergent and apparently inactive (see PUBMED:9544241) but are also part of this subfamily phylogenetically.
Links
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Statistics
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PSSM-Id: 213596
Aligned: 10 rows
Threshold Bit Score: 423.357
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4PGM_A         1 PKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNR 80  baker's yeast
P00950         2 PKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNR 81  Saccharomyces c...
WP_010894359   3 RKLVLLRHGQSQWNSMNRFTGWVDIGLTEQGHQEATMAGHLMKEEGLEFDVAHTSLLKRAIHTLQDALKALDQDWLPIYK 82  Xylella fastidiosa
WP_010881615   1 MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHK 80  Treponema
WP_002657375   2 yKLVLVRHGESEWNKENLFTGWTDVKLSDKGIDEAVEAGLLLKQEGYSFDIAFSSLLSRANDTLNIILRELGQSYISVKK 81  Lyme disease sp...
WP_001257024   9 TKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEK 88  Escherichia coli
P16290         4 HRLVMVRHGESSWNQENRFCGWFDAELSEKGAEEAKRGATAIKDAKIEFDICYTSVLKRAIRTLWTILDVTDQMWVPVVR 83  Norway rat
AIH41138       5 GSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGELIAEHDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRR 84  Mycobacterium t...
WP_010896059   4 NQVVLIRHGQSEWNTLNKFTGWHDAELDKKGKDEAKFAAILLKKEKFFFDCAHTSLLKRAIHTLQYILDELNQTWLSVKK 83  Buchnera aphidi...
WP_005693156   1 MELVFIRHGFSEWNAKNLFTGWRDVNLTERGVEEAKTAGKKLLDKGYEFDIAFTSVLTRAIKTCNIVLEESHQLWIPQVK 80  Haemophilus inf...

4PGM_A        81 SWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQ--KGDERYKYVDPN----VLPETESLALV 154 baker's yeast
P00950        82 SWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQ--KGDERYKYVDPN----VLPETESLALV 155 Saccharomyces c...
WP_010894359  83 SWRLNERHYGALQGLDKIDTAAKHGEEQVNIWRRSYDIQPPPIDLDDPSHP--MRDRRYAALDRK----VLPVTESLKNT 156 Xylella fastidiosa
WP_010881615  81 SWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCP--HTQASYRGVCASgrtpVLPFTESLKDT 158 Treponema
WP_002657375  82 TWRLNERHYGALQGLNKSETAAKYGEDKVLIWRRSYDVPPMSLDESDDRHP--IKDPRYKHIPKR----ELPSTECLKDT 155 Lyme disease sp...
WP_001257024  89 SWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYP--GHDPRYAKLSEK----ELPLTESLALT 162 Escherichia coli
P16290        84 TWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDTPPPPMDEKHNYYAsiSKDRRYAGLKPE----ELPTCESLKDT 159 Norway rat
AIH41138      85 SWRLNERHYGALQGLDKAETKARYGEEQFMAWRRSYDTPPPPIERGSQFSQ--DADPRYADIGG------GPLTECLADV 156 Mycobacterium t...
WP_010896059  84 SWRLNERHYGALEGLNKDEVIEKYGQKQVLLWRRSFDISPPQINIKDKRFP--GNDPRYSHLNIH----DIPLGESLEKT 157 Buchnera aphidi...
WP_005693156  81 NWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISPPDLDPQDPNSA--HNDRRYANIPSD----VVPNAENLKLT 154 Haemophilus inf...

4PGM_A       155 IDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKPsKP-S-YYLDPEA 232 baker's yeast
P00950       156 IDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKP-SK-PsYYLDPEA 233 Saccharomyces c...
WP_010894359 157 LERVLPYWNDAIAPQLNDNKTVLISAHGNSLRALYKYLNQESDEKILNVNIPTGIPLLFELSDTLQVvSY-R-YLGDPDA 234 Xylella fastidiosa
WP_010881615 159 VARVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLcGK-R-FLGNEAD 236 Treponema
WP_002657375 156 VARVIPYWTDEIAKEVLEGKKVIVAAHGNSLRALVKYFDNLSEEDVLKLNIPTGIPLVYELDKDLNPiKH-Y-YLGDESK 233 Lyme disease sp...
WP_001257024 163 IDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPlKR-Y-YLGNADE 240 Escherichia coli
P16290       160 IARALPFWNEEIAPKIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNQELKPtKP-MrFLGDEET 238 Norway rat
AIH41138     157 VARFLPYFTDVIVGDLRVGKTVLIVAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLDSAMRPlVRgG-TYLDPEa 235 Mycobacterium t...
WP_010896059 158 AKRVIPYWNKIVYPELKNNKKILIVAHGNSLRALIQHLYKIDNKAILDLNIPTAQPIILDFDNEKNPiKW-H-YLT---- 231 Buchnera aphidi...
WP_005693156 155 LERALPFWEDQIAPAMLSGKRVLVVAHGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNYvEH-Y-YL----- 227 Haemophilus inf...

4PGM_A       233 AAAGAAAVANQGK 245 baker's yeast
P00950       234 AAAGAAAVANQGK 246 Saccharomyces cerevisiae S288c
WP_010894359 235 AQRASEMVANQGK 247 Xylella fastidiosa
WP_010881615 237 VAARAQAVADQGK 249 Treponema
WP_002657375 234 IKKAMESVASQGK 246 Lyme disease spirochete
WP_001257024 241 IAAKAAAVANQGK 253 Escherichia coli
P16290       239 VRKAMEAVAAQGK 251 Norway rat
AIH41138     236 apagaaavagqgr 248 Mycobacterium tuberculosis
WP_010896059     -------------     Buchnera aphidicola
WP_005693156     -------------     Haemophilus influenzae
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