Conserved Protein Domain Family
SLC6sbd_GlyT1
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cd11498: SLC6sbd_GlyT1 
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain
GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
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Statistics
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PSSM-Id: 212067
Aligned: 4 rows
Threshold Bit Score: 1105.36
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
CAI19430      11 NGAVPSEATKRDqnlKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 90  human
A7Y2W8         6 NGAVPSEATKKDenlKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 85  African clawed ...
AAY55910      15 NGAVPGEPVKRDensRRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFLELSFGQF 94  zebrafish
NP_001026450  11 NGAVPGERSKQDksvKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQF 90  chicken

Feature 1                                                                                 #      
CAI19430      91 ASqGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNgsr 170 human
A7Y2W8        86 ASqGCLGVWRVSPIFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFASMNRVLPWTYCNNLWNTNNCAGVLSPNSSASfnl 165 African clawed ...
AAY55910      95 TSlGCLGVWKVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTNLLPWTYCNNPWNTPDCSGVVSTHRANAtfa 174 zebrafish
NP_001026450  91 ASqGCLGVWRVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFVSMTRVLPWTYCSNAWNTLDCVGVLDGNLSSHaa- 169 chicken

Feature 1                                                                                        
CAI19430     171 pa-alpsNLSHLLNHSlqRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF 249 human
A7Y2W8       166 ssqqnllNLTLGLNQTlkRTSPSEEYWRRHVLKISEDIGDFGEVQLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF 245 African clawed ...
AAY55910     175 nmsavvsGVTEIVNRTk-RTSPSEEYWRNYVLNISDGIGNFGEVRLPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTATF 253 zebrafish
NP_001026450 170 ------vNLTRLFNATqkRTSPSKEYWRRYVLNLSDDIGNLGEVRLPLLGCLGVSWVVVFLCLIKGVKSSGKVVYFTATF 243 chicken

Feature 1                                                                                        
CAI19430     250 PYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISIT 329 human
A7Y2W8       246 PYVVLTILFIRGITLEGAINGILYYLTPQWDKILHAMVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISIT 325 African clawed ...
AAY55910     254 PYVVLTILFIRGITLDGAISGIKYYLTPQWQKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCFRDSIIISVT 333 zebrafish
NP_001026450 244 PYVVLTILFVRGITLEGALTGIMYYLTPQWGKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISIT 323 chicken

Feature 1                                                                                        
CAI19430     330 NCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPiSPLWSLLFFFMLILLGLGTQFCLLETLVT 409 human
A7Y2W8       326 NCATSVYAGFVIFSILGFMATHLGVDVSEVADHGPGLAFVAYPEALTLLPiSPLWSILFFFMLILLGLGTQFCLLETLVT 405 African clawed ...
AAY55910     334 NCGTSVYAGFVIFSILGFMAHHLGVDVSEVADHGPGLAFVAYPEALTLLPiSPLWSLLFFFMLILLGLGTQFCLLETLVT 413 zebrafish
NP_001026450 324 NCATSVYAGFVIFSILGFMANHLGVDISKVADHGPGLAFVAYPEALTLLPiSPLWSILFFFMLILLGLGTQFCLLETLVT 403 chicken

Feature 1                                                                                        
CAI19430     410 AIVDEVGNEWILqKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 489 human
A7Y2W8       406 AVVDEIGNDWIIrWKTLVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAVMYIYGHRKYFKDIEM 485 African clawed ...
AAY55910     414 AVVDEIGTDWIIkNKTYVTLGVAIIGFLLGVPLTTQAGIYWLLLMDNYAASFSLVIISCIMCICIMYVYGHKNYFKDVEM 493 zebrafish
NP_001026450 404 AIVDEVGNEWIIrRKTFVTLGVAVAGFLLGIPLTTQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFKDIEM 483 chicken

Feature 1                                                                                        
CAI19430     490 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 569 human
A7Y2W8       486 MLGFPPPLFFQICWRFISPGIIFFILIFTVIQYRPIQYNDYLYPDWAITIGFLMALSSVICIPLYAIFKIWCSEGDTFLQ 565 African clawed ...
AAY55910     494 MLGFPPPIFFRICWRYVSPFIITFILIFTVIQYKPITYNDYVYPGWSLVIGFAMALSSVICIPIYALFKIAMSEGSTFLE 573 zebrafish
NP_001026450 484 MLGFPPPLFFQICWRFISPAIIFFILVFTVIQYRPISYNEYVYPTWAISIGFLMALSSVICIPIYAIYKVCHSEGDTLLE 563 chicken

Feature 1                                 
CAI19430     570 RLKNATKPSRDWGPALLEHRTGRYA 594 human
A7Y2W8       566 RLKNAVKPSKDWGPALQEHRTGRYA 590 African clawed frog
AAY55910     574 RLKNSVKPDPDWGPALQEHRKGRYA 598 zebrafish
NP_001026450 564 RLKNATKASKDWGPALAEHRSGRYA 588 chicken

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