Conserved Protein Domain Family
bHLH_TS_ASCL2_Mash2
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cd19743: bHLH_TS_ASCL2_Mash2 
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins
ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.
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Statistics
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PSSM-Id: 381586
Aligned: 4 rows
Threshold Bit Score: 88.4858
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #   # ### #    #                  ####                        
Q99929        49 AAAVARRNERERNRVKLVNLGFQALRQHVPHGg-ASKKLSKVETLRSAVEYIRALQRLLAEHDAV 112 human
KQK82426      47 AAAVARRNERERNRVRLVNLGFAALRQHVPHGa-ASKKMSKVETLRSAVEYIRALQRLLDEHDAA 110 blue-fronted amazon
XP_005991048  65 ASNAERRNERERNRVKLVNLGFASLRQHVPQLg-TGKKTSKVETLRSAMEYIRALQALLGGELSE 128 coelacanth
NP_001079106  43 SAPSERRNERERNRVKLVNLGFAKLRQHVPQAqgPNKKMSKVETLRSAVEYIRALQSLLMERSAG 107 African clawed frog

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