Conserved Protein Domain Family
DHR-2
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pfam06920: DHR-2 (this model, PSSM-Id:399717 is obsolete and has been replaced by 462040)
Dock homology region 2
This family represents a conserved region within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP. This region interacts with RAC1 and ELMO1.
Links
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Statistics
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PSSM-Id: 399717
Aligned: 57 rows
Threshold Bit Score: 297.635
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q54CA8          1604 ACLDSIAKFVKqncnnsllktsystsvssgnvkstttttstsrpsigsqqssngatrtqptiaQQIDELK------ERLf 1677 Dictyostel...
XP_001325706     838 KYLKNVSYLNK----------------------------------------------------DETKALY------QRV- 858  Trichomona...
EAY10227        1133 RALPLIQKVTD----------------------------------------------------SDIDKLTstkpsgKKFk 1160 Trichomona...
XP_001322768     994 LFFEVMSTKSKn---------------------------------------------------ISLIDFT------SLYr 1016 Trichomona...
EAY02445        1081 SFLEKMSTSSNn----------------------------------------------------ALRNFA------LTFm 1102 Trichomona...
XP_004366273    1687 EGKAFIGNLLQ------------------------------------------------------LLSLL------FDFr 1706 Cavenderia...
Q55BQ8          1717 ESKSFISNINQ------------------------------------------------------LLSLL------FEFr 1736 Dictyostel...
jgi:OSTLU_31873 1444 ETLQTL-QYAE----------------------------------------------------ICIRKLA------NAT- 1463 Ostreococc...
KRH13046        1302 KSVDEMKDETKnayllkecglpenal-----------------------vtvpekmtenrwswSEVKYLS------DSLl 1352 soybean
AQL06962         328 KSLEEMAD-VRskdllkdcglpvtal-----------------------eaapdgssdnmwswAEVKHLS------KCLv 377  Zea mays

Q54CA8          1678 gviknnVKIM--QHSYDpemkadlY------YNLSNTFIES-PDLRITLLKSFKEFLKQQKSMEEAAQVSIIAAALVS-- 1746 Dictyostel...
XP_001325706     859 ------LNYK--HLKND-------L------YEQSKVIKHS-PDAFVDLMLKLSENYHKEDMFSEEIQTKIYVVAYIV-- 914  Trichomona...
EAY10227        1161 allkeyFTGGfeQNNEEkg---diL------YTRALIVRYS-PDAQYLALKELAEHHHKYDYFAEEIQVKSMMLCVLA-- 1228 Trichomona...
XP_001322768    1017 klrensFCLL--EDINSfdkncelL------LQRLFLFKNC-PDMQLQILSEIAEKNLKNDNKIEYITSLFMKCSLIL-- 1085 Trichomona...
EAY02445        1103 kirknsMNLT--SEQVHfdrvpelM------MERVFLFRTC-PDHMLTILDEIANYHLNQDMKMEYVYTLILKMAIIL-- 1171 Trichomona...
XP_004366273    1707 t----lPM-D--RAFEEertiatlK------MM--EYFK-DrKDTYIKYVHELLSQHINSGYFTEAGFTFLLHADLYSwd 1770 Cavenderia...
Q55BQ8          1737 t----lPT-D--RAFEEertiatlK------MM--EYFK-DrKDTYIKYLYELLNQHLTNGYYTEAGFAIILHSDLYEwn 1800 Dictyostel...
jgi:OSTLU_31873 1464 --------MNpssm-------fdvScaveleSSLALALKSS-PAAHVKVLHSLSNRLAANEHWVEAAEAST-AAGIIA-- 1524 Ostreococc...
KRH13046        1353 laldgsLE----HALLApmmtmdrYaaaesfYKLAMAFAPV-PDLHIMWLLHLCDAHQEMQSWAEAAQCAVAVAGVVM-- 1425 soybean
AQL06962         378 qaldagLE----HALLDsvvtvdrYaaaegfYKLAMAYAPV-PDLHIMWLQHLCDAHQEMQSWAEAAQCAVAAAGVIM-- 450  Zea mays

Q54CA8          1747 --GYLKLL-NRFPKELL----ATDFTTVSP---NVAnEL-----TLPD------Lslledve-------geickldHFTD 1798 Dictyostel...
XP_001325706     915 --EHMIYL-HKIQDIFNt---NHPFANVCPssaNIV-PSgkvcsGIFT------D---------------------FFTK 960  Trichomona...
EAY10227        1229 --ENLSLK-SKIKNVFG----SSNFKSICQ------------------------NyndikcnykedlkingfcdspFFCI 1277 Trichomona...
XP_001322768    1086 --EYGCLL-GQIPNVFGtlhcLSLFNNICH---IS--KDlecskEICD------Dlpkvpc----------ycssvDFTQ 1141 Trichomona...
EAY02445        1172 --EFGVFI-GEIPNLFGtkhcASQFLKNLP---IA--ESiychdAFIN------Dmpkvpg----------fcgnpCFSQ 1227 Trichomona...
XP_004366273    1771 vdEEQQAS-------------VGAFTFTTPdqpAPItLPaepahSRKE-------------------------------- 1805 Cavenderia...
Q55BQ8          1801 teQ----I-------------VPPYTLALNqqpTt--MPqesssDRKV-------------------------------- 1829 Dictyostel...
jgi:OSTLU_31873 1525 ---------------------MQAFSIAAP---TLCvWFdhdvqSLRDsffalpDgaspvpav-----agircgteEISE 1575 Ostreococc...
KRH13046        1426 --QALVARnDGVWSKDH----VSALRKICP---MVSnEItseasAAEV------Egyg----------------asKLTV 1474 soybean
AQL06962         451 --QALVGRnDAVWSKEH----VTSLHKICP---IVNtDVsaeasAAEV------Egyg----------------asKLTV 499  Zea mays

Q54CA8          1799 TGFINLLKDAIQIQKSG-YFESAAETYRLLLPT----------YQHQKDWTKQRDAyqelvllcn--qiisenvvNQRI- 1864 Dictyostel...
XP_001325706     961 EFLQKLVKQTIDVCLESkYYEYGTSFIDDVVPLcqflfnsffnKEKEMMIEKLQNV-------------------EKRY- 1020 Trichomona...
EAY10227        1278 SSIVNLATEIITVANDKtYYEVAIAVSEYVVPI----------LESDIFFGAASNLiklaqtasq--klaackpgELRL- 1344 Trichomona...
XP_001322768    1142 LGLQGILNQIVNFCKENnLQSYSFVFADFLLPL----------LEYSRAWGECKQSiftlsdlfd-gyskqilndDDKM- 1209 Trichomona...
EAY02445        1228 SGLLGIMISTSEYCQKNqLFDAATYLYDIAMPL----------LEYSRLYSMCSQFlgifsglfr-aeaaapsmnSDVM- 1295 Trichomona...
XP_004366273    1806 ----RLVKMAIQYLDKGqVWEKCITLLQELSAY----------YDATYNFRGLADVanqqadl------ydkivsTERF- 1864 Cavenderia...
Q55BQ8          1830 ----RLLKMAIQYLDKGqVWERCITLLQDLKLH----------YEQTYNFKGLSEVsiqeaef------yekilnTERL- 1888 Dictyostel...
jgi:OSTLU_31873 1576 AQILTHLSRAVDLFTKGgHLEAAIRVNETAQIA----------WETHRQFDSLSEShammaelfrrldatsgvgdPKRYe 1645 Ostreococc...
KRH13046        1475 DSAVKYLQLANKLFSQAeLFHFCASILELVIPV----------YKSRRAYGQLAKChtlltniyesil------------ 1532 soybean
AQL06962         500 DSAVKYLQLANKLFTQAeLYHFCASIQELIIPV----------YKSRRAYGQLAKChtsltniyesil------------ 557  Zea mays

Q54CA8          1865 ----------FSNYYRVAFYCQDLiPDLHGKEFVYKENNYVRLSDLSERLKKQYCDKFG--ED-KFHLLPNNKPVDlSSL 1931 Dictyostel...
XP_001325706    1021 ----------FGNYFRVSFIGKKF-CHENGLVFVVHFPKLSRLLDVCKYYTNYCKEKFG--EKtKIEVVQSIGQIT-DEM 1086 Trichomona...
EAY10227        1345 ----------FGRYYRVRFFGAKL-GKQDGQTYIYREKLLTNVYNLANRLNDEYSKKYG-----AVETIMESSKVVqSKL 1408 Trichomona...
XP_001322768    1210 ----------SEKYFRVNFIGDPF-REEKDKSFVYHSNRLTTVFSLARTLIEQYTLLLN---C-PISLFQASI----AKR 1270 Trichomona...
EAY02445        1296 ----------QDRYFRVILTGKIF-GEDENKGYVYHANRLTRVFDISKQIVASYNQIYN---G-KIDLLQASA----GQR 1356 Trichomona...
XP_004366273    1865 ----------FAEYFRVGYYGRKFpQTIQGKEFLYRGFELERLADFTTRILAKFPNAELlkT--------TGEPS--ADI 1924 Cavenderia...
Q55BQ8          1889 ----------FAEYFRVGYYGKKFpLSIQGKEFLYKGFELERLPDFTARILAKFPDAELlkS--------TSEPT--TEI 1948 Dictyostel...
jgi:OSTLU_31873 1646 wditskpppeSATFWRIRLLGDVW-DKMQGLEWVYRESQDRTLGDMNKKIISQLSPYLP--SGtRVTAMSTNAE---SVI 1719 Ostreococc...
KRH13046        1533 eqesspipftnATYYRVGFYGVRF-GKLDKKEYVYREPRDVRLGDIMEKLSHTYESRMD--GNhTLHIIPDSRQVKaEEL 1609 soybean
AQL06962         558 eqeaspipfidATYYRVGFYGERF-GKLNKKEYVFREPRDVRLGDIMEKLSHIYEVKMD--GShTLHIIPDSRQVNaDEL 634  Zea mays

Q54CA8          1932 --DVKHIYIQIISVDPYLLPEELke-----------rTTPFQ----QNTHLNKFIFEIP--FTKN-GkTQYS------En 1985 Dictyostel...
XP_001325706    1087 knDKEKVYFCVTFIEPYHKDREN--------------SSGFE----SFHFVNNFFFERP--FTIS-G-NAQG------T- 1137 Trichomona...
EAY10227        1409 --DKNKIYIQPTSVEALIDESEMry-----------rKTDFE----KNDNLMKFYLDIP--FTKD-G-KSQG------N- 1460 Trichomona...
XP_001322768    1271 --ESSVGFIDVIQLTPKRNNRQ---------------KSDI------FNHHTQFYYDTP--FVPG-StNFVG------S- 1317 Trichomona...
EAY02445        1357 --DPTMGYINVTFIEPYHDDDD---------------ELSVG----QVNLTDEFYFDTP--FVPN-SnKAQG------T- 1405 Trichomona...
XP_004366273    1925 lnA-DAQYLLITIVNP-SSTEEIhkrvkhvtegtpsnSRAYH----RRNDVNVFLYSKA--FEKKsAaSPSNp----nNk 1992 Cavenderia...
Q55BQ8          1949 qnS-DGKYLLVTVVNP-SNLQEVekkqkfiipgtpnnSKSYL----KRNDVNVFVYSKP--FEKAsGaVVSNs----nNk 2016 Dictyostel...
jgi:OSTLU_31873 1720 --EEGCAGVQITAVQRDLESINQaaig------ggvgGTGFT-------RCGRFMFDTPvlFTED-GeVSQGqgavvaS- 1782 Ostreococc...
KRH13046        1610 --QPGVCYLQITAVDPVMEDEDLgsr--------rerIFSLStgsvRARVFDRFLFDTP--FTKN-G-KTQG------G- 1668 soybean
AQL06962         635 --QPGVCYLQITAVDPVMEDEDLgsr--------rerIFSLStgtvRARVFDRFLFDTP--FTKN-G-KTQG------G- 693  Zea mays

Q54CA8          1986 VTEQWKKKIILTTPNYFPYLKKRLPI--VKKEEIELTPIEASIELIQKKVTILKAELNSr-------pANTKTLQIHLQG 2056 Dictyostel...
XP_001325706    1138 VENQWLERTVLSTSDKMPSVSMRSLV--VREKSIKMSPIRVAYRQLHQRVINLENTINS---------GAYETLQTLLSG 1206 Trichomona...
EAY10227        1461 VATQCLRRVIFTPKTAMPCATKRVLV--ERVEEIEYSPIQVTCNSLSARVAMLKNAIQA---------ADYQTVQQLLHG 1529 Trichomona...
XP_001322768    1318 IETQWIRRTIITVENCLPSVLRRSFVdpKLTKNVDYEPIRVSYKKLREKTEELENSISN---------KNLQKIEQKLRS 1388 Trichomona...
EAY02445        1406 VETQWIRRTVIKTAQPLPCPLRRVQIlpDQEKVIEYEPIKVAYRQIRNRTKSILSAIND---------CDYLTIQQLLHG 1476 Trichomona...
XP_004366273    1993 FADLWIRNHFLIADSSFPTIHRRAEV--IKKEQTELTPIENAVNSVDLKNEELAEMVKKyla---npqLNLNPLAMALNG 2067 Cavenderia...
Q55BQ8          2017 FGDLWIKNHFLLTDSSFPTIHRRAQV--IKKLHVDLSPIENAINSVSSKNEELDEMVKKyek---spqLNLNPLAMALNG 2091 Dictyostel...
jgi:OSTLU_31873 1783 LRYQGRRRTIITVDGQFPSLLPRAPI--IDTTVEEMNPCQSAIQMLEEQTIALLAAAHAr-------rPHAELLQRLLQG 1853 Ostreococc...
KRH13046        1669 LEDQWKRRTVLRTEGSFPALVNRLLV--IKSESLEFSPVENAIGMIETRTAALRNELEeprssegdqlPRLQSLQRILQG 1746 soybean
AQL06962         694 LEDQWKRRTVLQTEGSFPALVNRLPV--TKSESLEFSPVENAIGMIETRTAALRNELEeprssegdqlPRLQSLQRILQG 771  Zea mays

Q54CA8          2057 CLLLQVNAGPLAICSSFLAEG---QYQN----HNAEHIQKLSEVIKEFSKTLDFGLK---FNASLTK--ED---GAELQK 2121 Dictyostel...
XP_001325706    1207 NIMISVNEGVVRIAEVFLNSPtteDYEDp---VILKYRVKLKNVFEDFLEKNREGLE---KHKNYAAehQN---FMPLHN 1277 Trichomona...
EAY10227        1530 NLMVQVNEGPSKMAEVFLNDG-----------QKGQYYDKLREIFRDFLKTNQEGLK---LHAKYILskPI---FTMMQH 1592 Trichomona...
XP_001322768    1389 ILCENRSEGPEKVAELFMN-------------IDNPKKQKLVKELTNLLISIEKGLKfvnKNCKLTPenE------VMQA 1449 Trichomona...
EAY02445        1477 SLLAQVNEGPAKIAEVFLQ-------------GDSPLRPKMKKEFLLFLDANEKGVK---KHAEWVAdnQA---FVALQV 1537 Trichomona...
XP_004366273    2068 SIDAAVNGGVSLYKEAFFEK------QDvldaISKPFIPKLSSALKNQVEILERGLY---IHSQRCP--EE---LRGLHE 2133 Cavenderia...
Q55BQ8          2092 SIDAAVNGGISLYKEAFYQV------PEpy-rpQKPFLSKLSSELTRQANILECGLI---IHSKRCP--DE---LRGLHE 2156 Dictyostel...
jgi:OSTLU_31873 1854 SLAAGVNGGVPSLIHSFFRTElpsAVAY--------HGEAMREA--EFL-----------TPARAVEvsPEtptPSSRHS 1912 Ostreococc...
KRH13046        1747 SVAVQVNSGVLSVCTAFLSGE---PATR----LRSQELQQLIAALLEFMAVCKRAIR---VHFRLIG--EE---DQDFHT 1811 soybean
AQL06962         772 SVAVQVNSGVLSVCTAFLSGE---PATR----LRSQELQQLIAALLEFMAVCKRAIR---VHFRLIG--EE---DQEFHT 836  Zea mays

Q54CA8          2122 QLDSGYDNFRKKLQE 2136 Dictyostelium discoideum AX4
XP_001325706    1278 ELSTKFEQLEKTLSQ 1292 Trichomonas vaginalis G3
EAY10227        1593 ELEAGYETLEFKLKP 1607 Trichomonas vaginalis G3
XP_001322768    1450 EFENGFELLKSKLET 1464 Trichomonas vaginalis G3
EAY02445        1538 QLEAGMDALREKLTP 1552 Trichomonas vaginalis G3
XP_004366273    2134 KLESFFPKFKSEVls 2148 Cavenderia fasciculata
Q55BQ8          2157 KLESFFPKLQSEIES 2171 Dictyostelium discoideum AX4
jgi:OSTLU_31873 1913 TPRLPMIHHKRGLSE 1927 Ostreococcus lucimarinus CCE9901
KRH13046        1812 QLVNGFQSLTAELSH 1826 soybean
AQL06962         837 QLVNGFQSLTAELSH 851  Zea mays
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