2ZXE


Conserved Protein Domain Family
FXYD3-like

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cd20328: FXYD3-like 
FXYD domain-containing ion transport regulator 3 and similar proteins
This subfamily includes FXYD domain-containing ion transport regulator 3 (FXYD3), FXYD9, and FXYD10, also called PLMS/Phospholemman-like protein. FXYD3, also known as mammary tumor 8 kDa protein (MAT-8), or chloride conductance inducer protein Mat-8, or phospholemman-like (PLML), may function as a chloride channel or as a chloride channel regulator. It associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature. Members here include mammalians and reptiles. FXYD9 is present in teleosts including: Danio rerio, Atlantic salmon, and Japanese Medaka fish. In general, the FXYD9 isoform has the highest degree of conservation among the examined teleost species, indicating that it may be involved in physiological processes that are not evolving within this group of vertebrates. FXYD10, present in shark, associates with and modifies the activity of Na,K-ATPase in vitro through interactions mediated by its transmembrane and cytoplasmic C-terminal domains. It is important in the phosphorylation and potassium deocclusion reactions, which are known to be controlled by A domain movements. It is thought that FXYD10 interacts with the A domain of the shark Na,K-ATPase alpha-subunit.
Statistics
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PSSM-Id: 410563
Aligned: 96 rows
Threshold Bit Score: 50.5882
Created: 3-May-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
trimer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:2ZXE: Squalus acanthias Na(+)/K(+)-ATPase regulatory FXYD protein (phospholemman-like protein) forms a heterotrimer with the alpha and beta subunits; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##### ## # #  ##  ##  #  ## ### ##              
2ZXE_G         2 DPEGPDNDERFTYDYYRLRVVGLIVAAVLCVIGIIILLAGKCRCKFNQNKR 52  spiny dogfish
XP_029416934  12 LAGLPALDANDPEDWHSLRVGGLICAGILCALGIIVLLSGKCKCKFRQKPS 62  Upper Galilee mountains blind mole rat
XP_021089539  12 LAGLPSLDANDPEDWYSLRVGGLICAGILCAVGIIVLMSGKCKCKFSQKPS 62  golden hamster
XP_030331040  21 NPLPPDATSPFYYDWHRLRVAGLVVAAVLCVVGVIVLLSGKCKCGSKASRR 71  Kakapo
XP_027569801   9 LVLLGDANNPFQYDWHHLRVAGLGVAAFLCVLGFIVLLSGKCKCRSKASHQ 59  Wire-tailed manakin
ELV09350      12 LAGLPALDANDPEDWYSLRVGGLICAGVLCAIGIIVLMSGKCKCKFSQKPR 62  Chinese tree shrew
OWK15758      12 LAALPALDANDPEDWYGLRVGGLIFAGILCAMGIIVLMSGKCKCKFRQKPS 62  Cervus elaphus hippelaphus
ELK05765      12 LAGLPALAANDPEDWHSLRVGGLICAGILCAMGIIVLMSGKCKCKFNQKPR 62  black flying fox
XP_016160861  11 ILGVLSLARGDPPDWCHLRVGGLVVAAVLSAVGIIILFSGMCKCRSKASRR 61  collared flycatcher
XP_030117385  19 RGDAPDASSPFQFDWCHLRVGGLTVAAVLSVLGVVVLLSGKCKCRSKARCR 69  zebra finch

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