Conserved Protein Domain Family
Peptidase_C15

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cl00237: Peptidase_C15 Superfamily (this model, PSSM-Id:412248 is obsolete and has been replaced by 444776)
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Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from proteolysis by other proteases until the pGlu is removed by a PGP. PGPs are cysteine proteases with a Cys-His-Glu/Asp catalytic triad. Type I PGPs are found in a wide variety of prokaryotes and eukaryotes. It is not clear whether the functional form is a monomer, a homodimer, or a homotetramer.
Statistics
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Accession: cl00237
PSSM Id: 412248
Name: Peptidase_C15
Created: 8-Feb-2008
Updated: 24-Nov-2020
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