Conserved Protein Domain Family
7tmA_S1PR5_Edg8
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cd15348: 7tmA_S1PR5_Edg8 
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
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Statistics
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PSSM-Id: 320470
Aligned: 4 rows
Threshold Bit Score: 399.968
Created: 25-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                  ##  ##
Q9H228        37 RADAVVCLAVCAFIVLENLAVLLVLGRHPRfhapMFLLLGSLTLSDLLAGAAYAANILLSgPLTLKLSPalWFAREGGVF 116 human
EMP39519      46 KADAVAFLAICALIVLENLVVLLAIWRNKKfhspMFYLLGNLTLSDLLAGLAYTANIAMSgANTLQLTPllWFLREGGVF 125 green seaturtle
NP_001120540  43 KAEAVFFLVVCVFIVLENLIVLLALWRNKKfhspMFYLLGNLTLSDLLAGVAYIVNILMSgANTLRLTPamWFVREGGVF 122 western clawed ...
AAH85656      34 KPEAIAFLIICLLIVVENAIVLVAIWKNKKfhmpMYYLLGSLTLSDLLAGFTYMVNIVTSgANTLKMTPvlWFLREGGVF 113 zebrafish

Feature 1          #                                                                             
Q9H228       117 VALTASVLSLLAIALERSLTMARRgPAPVSSRGRTLAMAAAAWGVSLLLGLLPaLGWNCLgrldaCSTVLPLYAKAYVLF 196 human
EMP39519     126 ITLAASVFSLLAIAIERHITMSRMkLYHSDKKGRMFLLVGATWATSVLLGVLPiLGWNCLdslaaCSTLLLLFSKSYILF 205 green seaturtle
NP_001120540 123 ITLTASIFSLLAIAIERHITMVRMkHYSGDKKGRMALLIGAAWLVSILLGVLPiLGWNCIsnlqsCSTILPLYSKNYLLV 202 western clawed ...
AAH85656     114 ITLAASVISLLAIAIERHVTMVRMkPYQGAKRGRMFGLIGASWLLSILLGILPiMGWNCIgnldeCSTVLPLYAKSFILF 193 zebrafish

Feature 1        #                                                                  #      #     
Q9H228       197 CVLAFVGILAAICALYARIYCQVRanarrlparpgtagttstrarrkPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVA 276 human
EMP39519     206 CITVFLAILVSITVLYARVFRMVKghsprlgsl------rkgmlkrsQKYMALLKTVTIVVGTFVACWLPLFLLLLLDVW 279 green seaturtle
NP_001120540 203 CISIFLAILIAIVVLYLRIYRIVKvnsqrlgtl------rkgtlkksQKYMALLKTVTIVVGTFIMCWLPLFVLFLFDVS 276 western clawed ...
AAH85656     194 CITVFTLVLMSIVVLYVRIFRIVKsntqrlgfgt----qrkglarksQKYLALLKTVTIVLGVFIACWLPLFVLLLLDFS 269 zebrafish

Feature 1                    #  #                         
Q9H228       277 CpartCPVLLQADPFLGLAMANSLLNPIIYTLTNrDLRHAL 317 human
EMP39519     280 CeaqaCGVLYKADYFLGLAMINSLLNPIIYTLTSkDMRRAI 320 green seaturtle
NP_001120540 277 CevnaCPILLKADYFLGLAMINSLLNPIIYTLTSrDIRRAI 317 western clawed frog
AAH85656     270 CpaqsCEVLFKADYFLGIAMINSLLNPIIYTLTSkDMRRAI 310 zebrafish

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