Conserved Protein Domain Family
TGF_beta_GDF9B
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cd19402: TGF_beta_GDF9B 
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins
GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Links
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Statistics
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PSSM-Id: 381672
Aligned: 7 rows
Threshold Bit Score: 216.219
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #   ## #         # ###                ##  ## ##  #    ##  # ##  #      
O95972       289 NQCSLHPFQISFrQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVL 368 human
NP_001006589 247 SDCSLRSFPVSFaQLGWDHWIIAPHRYNPRYCKGVCPRLLRDGYHAPNHAVVQNLVHQLVDANVPRPSCVPYRYSPISVL 326 chicken
XP_005992965 268 NECKLHSFRVSFhQLGWDHWIIAPHRYNPKYCKGDCPRILHYGYNSPNHAIVQNFINELVDQNVPRPSCVPYKYQPISVL 347 coelacanth
XP_007910653 294 NQCKLRSFLVSFqQLGWDHWIIAPPKYDPKFCKGACPRILHYGYHSPNHAIVQTFINEIIDKNVPRPSCVPLKYNPISVL 373 elephant shark
AAI24107     281 NNCKLYSSSVDFkDLGWDHWVIAPHKYNPGYCMGDCPRILHYGYNSPNHAIMQTFISELGVADIPLPSCVPYKYKRMSML 360 zebrafish
XP_018419745 270 NRCSLHPLWVSFhQLGWDHWIIAPHRYNPGFCKGDCPQILHSGYNSPNHAIIQNFISQVVDENVPRPSCVPYSYGPISVL 349 Nanorana parkeri
OCT65690     134 NQCSLHPFWVSFhQLGWDHWIIAPHRYNPGYCKGDCPRLLLSGYNSPNHAIIQNFINQVVNGSVPRPSCVPYSNGPISVL 213 African clawed ...

Feature 1                     ### #     #
O95972       369 MieaNGSILYKEYEGMIAESCTCR 392 human
NP_001006589 327 MiqhDGSILYKEYENMIAESCTCR 350 chicken
XP_005992965 348 MvegNGNILYKEYEDMVAQSCTCK 371 coelacanth
XP_007910653 374 Lk-eNDQIVYKEYEDMIAVSCTCK 396 elephant shark
AAI24107     361 VmgsNGQIDYKEYEDMIADSCTCR 384 zebrafish
XP_018419745 350 MiepGGNILYKEYENMMAESCTCR 373 Nanorana parkeri
OCT65690     214 MiepGGNILYKEYENMMAESCTCQ 237 African clawed frog

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