Conserved Protein Domain Family
P-type_ATPase_cation
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cd07543: P-type_ATPase_cation 
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p
Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Links
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Statistics
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PSSM-Id: 319843
Aligned: 12 rows
Threshold Bit Score: 1175.63
Created: 19-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
Q9HD20     214 EIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMse-iR 292  human
Q9LT02     170 KIATATEKWGRNVFDYPQPTFQKLMKENCMEPFFVFQVFCVGLWCLDEFWYYSVFTLFMLFMFESTMAKSRLKTLtd-lR 248  thale cress
P90747     163 HVKDAKYLLGDNKTEMIVPQFLEMFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLFMLMTFEATLVKQQMKNMse-iR 241  nematode
AAH55391   180 QLRAAEKRYGTNRAEMVVPDFLELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLFMLVAFEASLVQQQMRNMse-iR 258  zebrafish
EAL18937   202 SLEALKATYGLNECHIPIPKFAELFAEHAVAPFFVFQMFCVALWCLDEYWYYSLFTAFMLVVFECTVVFQRVKTLqe-fR 280  Cryptococcus neo...
AAI66048   176 DIKAAEKKYGINKAEMVVPDFLHLFKERAIAPFFVFQVFCVGLWCLDEYWYYSVFTLFMLVAFEASLVQQQMKNLse-iR 254  African clawed frog
EAL48257   150 KANEKHEYYGLNKCSIPIPTFMDLYKEQIMQPFFIFQVVCSILWMMDDMPIFAFMMLIMLFIFEGMTTFTRMKNYgnfkA 229  Entamoeba histol...
NP_584560  124 VEAELLKHFKKNRFDIVPPSFSELFLQHAVSPLFVFQVFSGLLWCLDEYVYQAMFSLVMLVVLESGLVFQRMMTArh-fR 202  Encephalitozoon ...
P39986     169 DLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALke-fR 247  Saccharomyces ce...
NP_609490  220 DIKRATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMse-iR 298  fruit fly
O14072     169 QSEIFLYRYGKNCFDIPIPTFGTLFKEHAVAPFFVFQIFCCVLWCLDDYWYFSLFSMFMIIALECSVVWQRQRTLte-fR 247  Schizosaccharomy...
Q9EPE9     211 EIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMse-iR 289  house mouse

Feature 1                                                                                      
Q9HD20     293 KMGNKPHMIQVYRs-------RKWRPIASDEIVPGDIVSIGrs-----pqENLVPCDVLLLRGRCIVDEAMLTGESVPQM 360  human
Q9LT02     249 SVRVDSQTVMVYRs-------GKWVKLLGTDLLPGDVVSIGrpstqtggeDKTVPADMLLLVGSAIVNEAILTGESTPQW 321  thale cress
P90747     242 NMGNKTYMINVLRg-------KKWQKIKIEELVAGDIVSIGrg-----aeEECVPCDLLLLRGPCIVDESMLTGESVPQM 309  nematode
AAH55391   259 RMGNKPYMIQVYRn-------RKWRPISSDELVPGDIVSVGrs-----pqDNLVPCDVLLLRGRCIVDEAMLTGGSVPQM 326  zebrafish
EAL18937   281 TMSITPYNVQAFRd-------GKWVSVISSELVPGDLVSILrt-----npDSGIPCDLLLLRGTCIVNEAMLSGESTPLL 348  Cryptococcus neo...
AAI66048   255 KMGNKPYMIQVYRn-------RKWRPIPSDEIIPGDIVSIGrs-----anDNLVPCDVLLLRGRCIVDEAMLTGESVPQM 322  African clawed frog
EAL48257   230 MAAMKPTTHTVYRd-------GIKTQVDCDHIYPGDLLVIT---------TGKAIADCVIIKGMCVVNESILTGESTPHM 293  Entamoeba histol...
NP_584560  203 RMSHSNVDVEILYdsrmnakkGEGVMGSSENLFPGDVVKISs--------SIHVPCDLLLVKGSCAVNEAMLSGESVPLT 274  Encephalitozoon ...
P39986     248 TMGIKPYTINVFRn-------KKWVALQTNELLPMDLVSITrt-----aeESAIPCDLILLDGSAIVNEAMLSGESTPLL 315  Saccharomyces ce...
NP_609490  299 KMGNKPYLIYAFRq-------NKWRHLGSDELLPGDLVSITrs-----qnDNIVPCDLVILRGSCIVDESMLTGESVPLM 366  fruit fly
O14072     248 TMSIKPYEIQVYRn-------KHWFPISTEDLLPNDVVSVLhn-----keDSGLPCDLLLLSGSCVVNEAMLSGESTPLV 315  Schizosaccharomy...
Q9EPE9     290 KMGNKPHMIQVYRs-------RKWRPVASDDIVPGDIVSIGrs-----pqENLVPCDVLLLRGRCIVDEAMLTGESVPQM 357  house mouse

Feature 1                                                                                      
Q9HD20     361 KEPIedlspdrv---ldlqadsRLHVIFGGTKVVQhippqka-ttglkpvDSGCVAYVLRTGFNTSQGKLLRTILFGvKR 436  human
Q9LT02     322 KVPIvgqrsde----klsikrnKNHVLFGGTKILQhspdks---fslktpDGGCLAVVLRTGFETSQGKLMRTILFStER 394  thale cress
P90747     310 KEPIedvekdki---fdietdsRLHVIFGGTKIVQhtapgkaaegmvkspDGNCICYVIRTGFNTSQGKLLRTIMFGvKK 386  nematode
AAH55391   327 KEPIedldpnri---ldlqtdsRLHIISGGTKVVQhspplra-saglkpvDNGCVAYVLRTGFYTSQGKLLRTILFGvKR 402  zebrafish
EAL18937   349 KESIelregtdr---ldmngadRNNVLFSGTKALQvekage---ggmttpDGGCLAVVLRTGFGTTQGQLVRTMIFStER 422  Cryptococcus neo...
AAI66048   323 KEPIedlnpeni---ldvsadsKLHVISGGTKVVQhtppqka-tsglkpvDNGCVAYVLRTGFNTSQGKLLRTILFGvKR 398  African clawed frog
EAL48257   294 REALstiidpntendvldlnvhKHHIIFGGTEVLQ---------------DDQCLGYVIHTGFKTAQGELLRTIISStER 358  Entamoeba histol...
NP_584560  275 KEDIserdaed----ifdggrdRRHILYAGTEIVMm-------------kDSPLVCFVLHTGFETEKGGLVRKMMCA-EE 336  Encephalitozoon ...
P39986     316 KESIklrpsedn---lqldgvdKIAVLHGGTKALQvtppehk-sdippppDGGALAIVTKTGFETSQGSLVRVMIYSaER 391  Saccharomyces ce...
NP_609490  367 KESLesldnldv--emdaegdgKLFVLFGGTKVVQhtaptk---eslrapDGGCIGYVIRTGFNTSQGKLLRTILFGaNR 441  fruit fly
O14072     316 KESIelrpeeav---idvdeldKNAVLFGGTRVLQvtqspf---cklktpDNGVPAIVLRTGFETSQGSLVRTMVFSsEK 389  Schizosaccharomy...
Q9EPE9     358 KEPIedlspdrv---ldlqadaRLHVIFGGTKVVQhippqka-tsglkpvDNGCVAFVLRTGFNTSQGRLLRTILFGvKR 433  house mouse

Feature 1                                                                                      
Q9HD20     437 VTANNLETFIFILFLLVFAIAAAAYVWIEGtkdpsrnRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCT 516  human
Q9LT02     395 VTANSWESGLFILFLVVFAVIAAGYVLVKGledptrsKYKLLLGCSLIITSVIPPELPMELSIAVNTSLLALVRRGIFCT 474  thale cress
P90747     387 ATANNLETFCFILFLLIFAIAAAAYLWIKGsvdetrsKYKLFLECTLILTSVIPPELPIELSLAVNSSLMALQKLGIFCT 466  nematode
AAH55391   403 VTANNLETFIFILFLLVFAIAAAVYVWVEGtkdpsrnKYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYVFCT 482  zebrafish
EAL18937   423 VSANTFEAFLFIGFLLIFAIAASAYVWIKGler-gmvKGKLLLDCVLIITSVVPPELPMELSLAVNASLVALQKYAIFCT 501  Cryptococcus neo...
AAI66048   399 VTANNLETFIFILFLLVFAIAAAAYVWIEGtkdpsrnRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYVYCT 478  African clawed frog
EAL48257   359 KTANNLESFVVILFLLVFALIAAGYVFIDGink-gksFWKLVLSCVLIITNVVPPELPMELTNAINYSLVSLKKQFIFCT 437  Entamoeba histol...
NP_584560  337 VTVNDREAFIFILALLVFAIVASFYAYREGkkm-gksNYKLLLEVILILTNVVPTELPMELSMAVNSCVRALARKGVYCL 415  Encephalitozoon ...
P39986     392 VSVDNKEALMFILFLLIFAVIASWYVWVEGtkm-griQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCT 470  Saccharomyces ce...
NP_609490  442 ATENNVETFAFIAFLMVFAVAAASYVWVKGsedpernRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCT 521  fruit fly
O14072     390 VTANNRESLYFILFLLVFAIAASGYVWHVGskt-ersRYKLMLDCVMIITSVVPSELPMELSMAVNASLGALSKYYIYCT 468  Schizosaccharomy...
Q9EPE9     434 VTANNLETFIFILFLLVFAIAAAAYVWVEGtkdpsrnRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCT 513  house mouse

Feature 1                      #######                                                         
Q9HD20     517 EPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVtpvssi----pvethrALASCHSLmq----lDDGTLVGD 588  human
Q9LT02     475 EPFRIPFAGKVDLCCFDKTGTLTSDDMEFRGVGGLSNCEEAetdmskv---pvrtleILASCHALv-----fVENKLVGD 546  thale cress
P90747     467 EPFRIPFAGKVDICCFDKTGTLTTDNLVVEGVALNNQKEGMirnaedl---pheslqVLASCHSLv-----rFEEDLVGD 538  nematode
AAH55391   483 EPFRIPFAGKVEICCFDKTGTLTSDSLVVRGVAGLREGKQVmpvsei----pvdthrVVATCHSLvt----lDDGQLVGD 554  zebrafish
EAL18937   502 EPFRIPWAGRVDVCCFDKTGTITGEDLVVEGIAGVNSADPKalrpvte--snkettlALAAAHALvl----lDDGTIVGD 575  Cryptococcus neo...
AAI66048   479 EPFRIPFAGKVEICCFDKTGTLTSDSLVVRGVAGLKDGKEVtpisdi----pldthrVVATCHSLvq----mDDGTLVGD 550  African clawed frog
EAL48257   438 EPFRIPFAGIVDICAFDKTGTLTSDEVSVAGIAGLKDDPFKlrsside--vpqeiinVIVACNSLsk----mKDGSVIGD 511  Entamoeba histol...
NP_584560  416 EPFRIPYAGKVNVCCFDKTGTLTETVMEVAAVKHETENSVS----------------VLASCHSLl-----sLNGKVTGD 474  Encephalitozoon ...
P39986     471 EPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENirhlysaaeapestilVIGAAHALvk----lEDGDIVGD 546  Saccharomyces ce...
NP_609490  522 EPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGACvpieka----egntvqVLACCHSLa-----lLDDGLVGD 592  fruit fly
O14072     469 EPFRIPLSGHLDICCFDKTGTLTEEHMVVQGIAGVNRKDPYsleklsd--asndailAIATAHTLvlleqegETPKVVGD 546  Schizosaccharomy...
Q9EPE9     514 EPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVtpvssi----piethrALASCHSLmq----lDDGTLVGD 585  house mouse

Feature 1                                                                                      
Q9HD20     589 PLEKAMLTAVDWtltkdekvfp---rsiktqglkIHQRFHFASALKRMSVLASyeklgstdlCYIAAVKGAPETLhsmfs 665  human
Q9LT02     547 PLEKAALKGIDWsykadekalp---rrgngnsvqIMQRYHFASHLKRMSVIVRiq------eEYLAFVKGAPETIqerlv 617  thale cress
P90747     539 PLEKACLSWCGWnltkgdavmppktaakgisgikIFHRYHFSSAMKRMTVVAGyqspgtsdtTFIVAVKGAPEVLrnmya 618  nematode
AAH55391   555 PLEKAMLTAADWtltkdekvfa---rstktpglkIHQRFHFTSALKRMSVLASyermgstelCYISTVKGAPETLrnmfs 631  zebrafish
EAL18937   576 PMEKTTLAALDWklsrgdqispvskespykaqihIRRRYQFSSALKRMSTISSvsds--qgkKWVVAVKGAPETLksmyv 653  Cryptococcus neo...
AAI66048   551 PLEKAMLTAVDWtvtkdekvfs---ksiktqglkIHQRFHFASSLKRMSVLASyerpgstdlCYVATVKGAPETLhtmfs 627  African clawed frog
EAL48257   512 PAEKAALEFSKWnltsdgrftp---skktnkqiqPIQRFPFSSLLKRMSVVVAikdfntntkTIMGFVKGAPEILkgmfk 588  Entamoeba histol...
NP_584560  475 PLETSIYEHLRNteplns----------kclehtIHKAYSFCSELRRMTVVVEak------gKRFVGMKGAPEVVkly-l 537  Encephalitozoon ...
P39986     547 PMEKATLKAVGWaverknsny-----regtgkldIIRRFQFSSALKRSASIAShn------dALFAAVKGAPETIrerls 615  Saccharomyces ce...
NP_609490  593 PLEKATLAAVDWtltkmdsvip---krpqfkplkIIQRYHFSSALKRMSVLAGhlipysnevKHIGAVKGAPEVIqkmlr 669  fruit fly
O14072     547 PMEKATVENLGWsiekknfvsapegsvfykgkvqIIRNFQFSSALKRQSSVSNvrvs-ggsfKTFVSVKGAPEVIatmlr 625  Schizosaccharomy...
Q9EPE9     586 PLEKAMLTAVDWtltkdekvfp---rsiktqglkIHQRFHFASALKRMSVLASyeklgstdlCYIAAVKGAPETLhsmfs 662  house mouse

Feature 1                                                                                      
Q9HD20     666 qcPPDYHHIHTEISREGARVLALGYKELghlthqqa-revkreaLECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVV 744  human
Q9LT02     618 dvPAQYIETYKRYTRQGSRVLALAYKRLpdmmvsea-rdmdrdaVESDLTFAGFAVFNCPIRPDSAPVLLELKNSSHDLV 696  thale cress
P90747     619 dlPSDYDETYTRLTRQGSRVLAMGIRKLgetrvgel-rdkkrenFENDLAFAGFVVISCPLKSDTKTMIREIMDSSHVVA 697  nematode
AAH55391   632 ecPASYDEVHREMSREGARVLALGYKEMghlshqqv-revsreqLECDLRFAGFMVVSCPLKSDSKAVIREIQEASHHVV 710  zebrafish
EAL18937   654 qvPDWYEETYRWYTRRGSRVLALGVKYMdvqadki--nqihrdhVECKLSFAGFLVFHCPLKPDAVETLKMLNDSSHRCV 731  Cryptococcus neo...
AAI66048   628 hcPEYYNQVHTEISREGARVLALGYKELghlthqqv-revkremLECDLRFAGFIVVSCPLKADSKAVIKEIQNASHNVV 706  African clawed frog
EAL48257   589 eiPHHYDNVNRFFTLQGMRVLAFGYKAIkngekn----kyirddIESDLEFGGFILFSSPIKKESNETIKQLKESGHDVV 664  Entamoeba histol...
NP_584560  538 dsVPEFYDDYKKYAADGYRVLALGFKPIekqdk------ydrtdVESKLSFAGFILFDCKLKKNVRKTIESLHGSGHKVI 611  Encephalitozoon ...
P39986     616 diPKNYDEIYKSFTRSGSRVLALASKSLpkmsqski-ddlnrddVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSI 694  Saccharomyces ce...
NP_609490  670 evPADYEKVYLEYARRGARVLALGIKDLgtlgaqrv-remkreeVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVV 748  fruit fly
O14072     626 evPKDYEKIYKDYGRKGSRVLALGYKYFknyipenqvsdlsresIESDLVFAGFLIFTSPLKEDARQTVQMLNNSSHRCM 705  Schizosaccharomy...
Q9EPE9     663 qcPPDYHHIHTEISREGARVLALGYKELghlthqqa-reikreaLECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVV 741  house mouse

Feature 1                                                                                      
Q9HD20     745 MITGDNPLTACHVAQELHFIEKAHtli-lqPPSEKGRQCEWRsidgsivlplargspkalaley------alcltgdgla 817  human
Q9LT02     697 MITGDQALTACHVAGQVHIVSNPVl-----ILGRSGSGNEYKwvspdekeiipysekeietlae------thdlciggds 765  thale cress
P90747     698 MITGDNPLTACHVSKVLKFTKKSLptl-vlDEPADGVDWMWKsvdgtielplkpetknkmerkaffn-shefcltgsafh 775  nematode
AAH55391   711 MITGDNPLTACHVARELHFIQKEHt----lILQQSSSQAEWQwvsidgsvslplppssvseliqr-----ydlcvtgegl 781  zebrafish
EAL18937   732 MITGDNPLTAVHVARDVEIVDREVmi---lDLKEGTTSNELVwrnvdetnvipvnssepfdqslf----knydicitgaa 804  Cryptococcus neo...
AAI66048   707 MITGDNPLTACHVAEELNFIEKPHtlilqpAQDTRDSPWLWQsidgtislpafpdnvqaftsny------ylcltgegls 780  African clawed frog
EAL48257   665 MITGDSIFTAAHVAEELTITSKDKv-----MLIKEKEEWKWTdmegleispfntkqvssevinrh-----iclsgealsh 734  Entamoeba histol...
NP_584560  612 MITGDNVLTARNVSKKIGISDKAV------EGSEIDKVLESD-------------------------------------- 647  Encephalitozoon ...
P39986     695 MITGDNPLTAVHVAKEVGIVFGETl-----ILDRAGKSDDNQllfrdveetvsipfdpskdtfdhsklfdrydiavtgya 769  Saccharomyces ce...
NP_609490  749 MITGDSPLTACHVARELRFTRKKLii---lTPPEEDRKNNWSwvsidgdqsyeldtkpgskklshllathdlcitgeglq 825  fruit fly
O14072     706 MITGDNPLTAVYVAEQVGIVEKPTlv--ldIKHENEKILEWKstddtinlpmnphksleaslye------kydlcitgra 777  Schizosaccharomy...
Q9EPE9     742 MITGDNPLTACHVAQELHFIDKAHtli-lhPPSEKGQPCEWRsidssivlpltlgspkalaleh------alcltgdgla 814  house mouse

Feature 1                                                                                      
Q9HD20     818 hlqatdpqqllrLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLanapervverrrrpr 897  human
Q9LT02     766 iemlqatsavlrVIPFVKVFARVAPQQKELILTTFKAVGRGTLMCGDGTNDVGALKQAHVGVALLnnklplspsdsskdd 845  thale cress
P90747     776 hlvhnehtflreLILHVKVFARMAPKQKERIINELKSLGKVTLMCGDGTNDVGALKHANVGVALLtnpydaekaaekeke 855  nematode
AAH55391   782 arlkfdpqllsaLLPHVRVFARVSPKQKEFVITSLKGLGFVTLMCGDGTNDVGALKHAHIGVALLanapermpekkkrnk 861  zebrafish
EAL18937   805 lkqydalpsvtdLIKHTYVYARVSPAQKEFIITTLRSLGYITLMAGDGTNDVGALKAAHIGVALLdgspedlkkiaehqk 884  Cryptococcus neo...
AAI66048   781 ylhsarrdmllaLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHAHVGVALLanaperlpekkrkpr 860  African clawed frog
EAL48257   735 ikeecskeiiqtILSKTKVYARVTPQQKEEIVLLLKEMGNIVLMCGDGTNDVGALKHADVGIAVLntlpsekekkeaemi 814  Entamoeba histol...
NP_584560  648 ------------EFFSVSIFARADPAHKEKIIEKYNKAGRYTLMCGDGTNDVGALKSAHVGIALMeapvavkkkgepktr 715  Encephalitozoon ...
P39986     770 lnaleghsqlrdLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLngteeglkklgeqrr 849  Saccharomyces ce...
NP_609490  826 ylqqnqpqymrqLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLtsapvkrkrteeeqq 905  fruit fly
O14072     778 lsqiinpdvimsIFTHAWVYARVSPSQKEFMISTLKHNGYITLMCGDGTNDVGALKQAHVGVALLnaseedmlemqerar 857  Schizosaccharomy...
Q9EPE9     815 hlqavdpqqllcLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLanapervverrrrpr 894  house mouse

Feature 1                                                                                      
Q9HD20     898 dsptlsnsgiratsrtakq----------------------------------------------------rsglppsee 925  human
Q9LT02     846 kskskksklplepasktitqngegss-------------------------------------kgkippqnrhltaaelq 888  thale cress
P90747     856 kkakieearslvrsgaqlpqrpgapgappa-----------------------------anaarrdappgararaplppm 906  nematode
AAH55391   862 ekeyssgesrpgppvptsggkls-------------------------------------------sraarqrlmaqree 898  zebrafish
EAL18937   885 lermkkvyeqqvrisarfnqpppppppalreay------------------------pelvktqqqvakahegakkanpl 940  Cryptococcus neo...
AAI66048   861 eaisdgrpsghsfnsnsikpts---------------------------------------------raaknrimsqree 895  African clawed frog
EAL48257   815 klgiipmpakptpkpltpee-------------------------------------------------ierrrrmtpqe 845  Entamoeba histol...
NP_584560  716 e------------------------------------------------------------------------------- 716  Encephalitozoon ...
P39986     850 legmkmmyikqtefmarwnqpqppvpepiahlfppgpknphylkaleskgtvitpeirkaveeanskpvevikpnglsek 929  Saccharomyces ce...
NP_609490  906 qaaanaaaiaaqaqananqq-------------------------------------------------lttreralrrr 936  fruit fly
O14072     858 nqklmgvyekqiqlakrfnlptppvppalchafppgpnnphr------ektqeglnkvledletkkasdvqlteaekaae 931  Schizosaccharomy...
Q9EPE9     895 dspvlsnsgprvsrstkq-----------------------------------------------------ksallspee 921  house mouse

Feature 1                                                                                      
Q9HD20     926 qptsqrdrlsqvlrdledestpivKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVL 1005 human
Q9LT02     889 rqklkkimddlnndegdgrsaplvKLGDASMASPFTAKHASVAPVTDIIRQGRSTLVTTLQMFKILGLNCLATAYVLSVM 968  thale cress
P90747     907 anaaqarldnlmkeleeeekaqviKLGDASIAAPFTSKYTSIASICHVIKQGRCTLVTTLQMFKILALNALVSAYSLSAL 986  nematode
AAH55391   899 qlaaqkerisqvlreleedqiqvaKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVL 978  zebrafish
EAL18937   941 ekfdmatitsklseldedqdvpqiKLGDASCAAPFTSKLSNVSAISNIIRQGRCTLVATIQMYKILALNCLITAYSLSVQ 1020 Cryptococcus neo...
AAI66048   896 qqalqrerisqvlkeleedqlqvvKLGDASIAAPFTFKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYGQSVL 975  African clawed frog
EAL48257   846 rseflknelrkafeglpddestvaKFGDASMASPFSCKSIEVTPVCQILKQGRSTLVTTQQMFRILALNCLISAYDLSVL 925  Entamoeba histol...
NP_584560  717 --------ermmesiskdlgedkiNLGDASVAAPFTAKTGSLDSVLDIIRQGRSALVTTIQMYKILALNSLVSAFSLSVL 788  Encephalitozoon ...
P39986     930 kpadlaslllnsagdaqgdeapalKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSII 1009 Saccharomyces ce...
NP_609490  937 qehlnqtqarlqnalrdmeeqtmvKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVL 1016 fruit fly
O14072     932 rranlankmfdtlanasddeapklKLGDASVAAPFTSKLAVVSSITNIVRQGRCTLVALVQMHKILALNCLITAYSLSVL 1011 Schizosaccharomy...
Q9EPE9     922 ppashrdrlsqvlrdleeestpivKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVL 1001 house mouse

Feature 1                                                                                      
Q9HD20    1006 YLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFFVHFLSLVYLYREAQARspekqe 1085 human
Q9LT02     969 YLDGVKLGDVQATISGVLTAAFFLFISHARPLQTLSAERPHPSVFSVYLFLSLIGQFAVHLTFLVYSVKEAEKHmpeeci 1048 thale cress
P90747     987 YLDGVKFSDTQATIQGLLLAACFLFISKSKPLKTLSRQRPMANIFNAYTLLTVTLQFIVHFSCLLYIVGLAHEAntekap 1066 nematode
AAH55391   979 YLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKSLSKERPLPNIFNLYTVLTVLLQFAVHFCSLVYLYKGAQTRspprse 1058 zebrafish
EAL18937  1021 YLDGIKFGDYQVTITGMLMSVCFLCISRAKPVEKLSKERPLGNIFNLYVLLSVLLQFAIHIVALVYITGLSKSLedrgei 1100 Cryptococcus neo...
AAI66048   976 YLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKHLSRERPLPNIFNLYTILTVLLQFLVHFCSLVYLYHGALARtearke 1055 African clawed frog
EAL48257   926 KIEGVKNGDVQMTVTGILLSICFLMLSNTQPLDKLSKHHPTKTIFAPFHVLSVLSQAFIHFVVIQLALKWGKEAagpdyk 1005 Entamoeba histol...
NP_584560  789 DCMGVRYGDVQLTASGLLIGFAFMFLTQSRPLEEISKKRPLTNIINPYIVSSVVLQVVVHIASFFIMIGRIRNVetpv-- 866  Encephalitozoon ...
P39986    1010 YMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLeprepq 1089 Saccharomyces ce...
NP_609490 1017 YIDGIKFSDTQATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTSQANILappreg 1096 fruit fly
O14072    1012 HLDGIKFGDTQYTISGMLMSVCFYCVSRARPLETLSKERPQAGIFNTYIIGSVLGQFAIHIVTLIYITRVVYLYedplek 1091 Schizosaccharomy...
Q9EPE9    1002 YLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFSVHFLSLVYLYREAQARspekqe 1081 house mouse

Feature 1                                                              
Q9HD20    1086 q-------fvdlykeFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPL 1134 human
Q9LT02    1049 ----------epdasFHPNLVNTVSYMVSMMLQVATFAVNYMGHPFNQSIRENKPF 1094 thale cress
P90747    1067 ---------vdleakFTPNILNTTVYIISMALQVCTFAVNYRGRPFMESLFENKAM 1113 nematode
AAH55391  1059 q-------fvdlykeFEPSLINSTVYIMSMAMQMATFAINYKGHPFMESLTENRPL 1107 zebrafish
EAL18937  1101 ----------dlekkFEPTLLNTAIYLLGLSQQVSTFVLNFQGRPFREGIRENPPL 1146 Cryptococcus neoformans var. neoformans ...
AAI66048  1056 e-------fvdlykeFEPSLVNSTVYIMSMAMQMATFAINYKGHPFMESLRENKPL 1104 African clawed frog
EAL48257  1006 i--------peedaeFKPTLVNSIVFIVSNIINVTTFAVNYVGEPYRKNITEYKPL 1053 Entamoeba histolytica HM-1:IMSS
NP_584560  867 -----------ysekFSPSLMNSALFFLSTTQQISTFLVNYIGRPFRESLLENKKL 911  Encephalitozoon cuniculi GB-M1
P39986    1090 ---------vdlekeFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGM 1136 Saccharomyces cerevisiae S288c
NP_609490 1097 kvklyidmdaeektkYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSNRML 1152 fruit fly
O14072    1092 ---------vdleetFKPSLLNTAIYLLQLIQQVSTFAINYQGRPFREALSENKGM 1138 Schizosaccharomyces pombe 972h-
Q9EPE9    1082 q-------fvdlykeFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPL 1130 house mouse

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