Conserved Protein Domain Family
CENP-K

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pfam11802: CENP-K 
Centromere-associated protein K
CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.
Statistics
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PSSM-Id: 463355
Aligned: 15 rows
Threshold Bit Score: 206.075
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016160370   7 EISNATGPVDAKEELLDECQSIWKEMEEYQSKLM---------LLGTETLLPSDAKLSLLLLQWKTLSVECHQWQVKSPE 77 
EHB02756      10 STTDMEVVTDIEEELIKACEEMWKDMEECQNKLS---------LIGAETLSNSNAQLSLLIMQVKCLTAELSQWHKETPE 80 
1_pfamImport   1 SSTDVRDITDSEQELVKECEEMWRDMEEYQNKLS---------LIGTKTLTDSNAQLSLLILQAKCLTAELRQWQKETPE 71 
XP_003759448  12 DILDKEYVMDRKDRIIEECEELWKQMEKYQQEIT---------LAEGERLNCSDAQLTLLMMRLKNLTAEYNQWLERTPD 82 
XP_007486455  12 DIENKEYIVDRKDKLIEECEELWKQMEKCQQEIA---------LAGGERLNHSDAQLTLLMMRVKSLTAECNQWLERTPD 82 
XP_015132795  30 IMSDSVCPIDAKEELLRECENIWKEMEKCQSKLT---------LLAAEPVPESDAKVSLLLTRMQALRAEYHQWQKRNPE 100
XP_002934240  29 ISKTSQAPEEAREELLQQCEEIWKQMEECQSKLT---------MSGPETLPEMDVQLYLLMMQVKALTAEYEQWQKRTPE 99 
NP_001243594  17 TSEDTGCMSAAKAVLLDECEEQFGLLQKLQNEII---------MADTEAY---DDQSNEAVNRLIAITSELEQWQEIEPK 84 
XP_001628227   5 ENSSVTEKTSYMQDLKDQCEGLWLHIHQTHARLRsraenmtcfLPGEENL--EKIHEEILKAKEKRLQAEYAAIESSGVE 82 
XP_005997501  29 LTANGQRSAEAKEILVQECEVVWREMEECQRKLS---------LLEPEALLDSDVQLSVLMARVKALMAEHNQWQNRKPD 99 
XP_016160370  78 IISTNPEVLLELGKEELQKVKNDLEMVLSAVRSKNKKLEEDLKREKQWYEEQKHMTAALTKIEEEAKPQVGQPSTE-RLe 156
EHB02756      81 NCSISFPFGVALGDLEFQKLSHDLEMVLSTIQSKNENLKEELEREQQWLDEQQEIMKSLNVIYSELKKQVVTFSES-RI- 158
1_pfamImport  72 IIPLTDDVLTTLAEEEFQKLRHDLEMVLSTIQLKNEKLKEDLEREQQWLDEQQQIMESLNVLHSELKNEVVPFSESrRG- 150
XP_003759448  83 IIPLNPESLITLGKEELQKLHHNLEMLLSTVQSKNQQLQEDLRREQEWLNEQEELGASLNEMCKELKNQVIPVSEK-RT- 160
XP_007486455  83 IIPLNPESLVVLGKDELQKLDHNLEILLSTIQSKNQKLKEDLTREQEWLNEQEHLVTSLSKKCKERKNQVIPFSEQ-RT- 160
XP_015132795 101 LISTNPEVLLLLGEEELQKVKKELEMVLSAVQLKNEKLKEDLEREQQWHDEQVQILNAFKEIEEEMKKEVVTDSEK-RV- 178
XP_002934240 100 IISDNQDVLLAVGKEELDKVARELEMVLSSVQAKNKKLKKDLEKEQNWLDGQQKLVDALTSRQDELKNQLSTFSEK-RV- 177
NP_001243594  85 LLTTNTEVLLAVGKKELQRLHSQLKMVLSCSQAKLDAQKKILKREQTWQSEKQEALNSVTEKIARLQ------QEKqKSd 158
XP_001628227  83 VPSMKEEYLDASLKQQLAQNTSQLDDTLLILKSKRKEIAEQLEREKEILEQHKDIEISLLNKTKKIEDTKENFQSGtSK- 161
XP_005997501 100 VLCTNPEVLVTLGKEEIQKVNKELEMVVSCVLMKNKKIREDLEREQKWLAEQQELVKALAERHQALKTDVVQLSEK-RA- 177
XP_016160370 157 ikeSSELKNKILKLKTFKKKLLTTLGEFLDEHFPPLEegeNT--ENK----NSSTKPA-VKLITLKEILESLINKLLTTP 229
EHB02756     159 ---FNELKTKILYIKEFKEKLLITLGEFLEDHFPLPN---GTlkKKK----KNIQEAT-KQLITLHEVLEILINRLFDVP 227
1_pfamImport 151 ---GGKIEELMINMVKRKEDLGLLIGWKWNNIYSLQS-------KKK----KNVQEPT-AQLITLHEMLEILINRLFDVP 215
XP_003759448 161 ---FLEMKTKMTKIKKHKEKLLTSLGEILDKHFPLPEengS---KKR----KRECQPN-AQLITLHEILEILINALLHSP 229
XP_007486455 161 ---FFEMNTKMTKIQSQREKLLNSLGEFLDKHFPPPEengN----KR----KRECKPT-AQLKTLREILEVLINSLLRSP 228
XP_015132795 179 ---FQELKNQMLELKEYKKKLMNALGEFLEEHFPLPEkngNA--KKK----RYSEEPP-EQVITIHEILEILLNQLMSTP 248
XP_002934240 178 ---FQDIANKLFKVRAYKEELLSALGDFLEEHFPLPEeqeNQskKKK----GQSGKKT-VPLMTLHEILEILINKLMTTP 249
NP_001243594 159 hsvSQEMKRKIHKLKEYHSSLMEMLSDMLAEHFPLPDpqeNGskKKR----AAAYDAAeINLISLSEIIERLTNKTLETP 234
XP_001628227 162 ---VRELERKQRIAETQLKQVMRKLGVFLREHFPLPTledVEvkRKTvlqgEQTLDPT-INYVTLQEMLEELMNTQHDRP 237
XP_005997501 178 ---LQELGGKIQKIKVYQEELLIALGTFLEDHYPLPKqwgNAskKKK----TQVDEPC-LYLITLHEILENLINKLMISP 249
XP_016160370 230 HEPYITINESFWPPYIELLLRYGIAVRHPQDPGRMRLQPF-Q 270
EHB02756     228 HDPYVKISDSFWPPYIELLLRNGIALRHPEDPTRIRLEAFhQ 269
1_pfamImport 216 YDPYVKISDSFWPPYIELLLRNGIALRHPEDPTRIRLEAFhQ 257
XP_003759448 230 HDPYVKINDSFWPPYIELLLRTGIVLRHQDDPSQIRLEAFhQ 271
XP_007486455 229 YNPYVKIDDSYWPPYIELLLRNGIALRHQDDPNQIRLEAFhQ 270
XP_015132795 249 HEPYVTVDDSFWPPYLELLLRSGIVLRHPEDPNRIRLEAFhE 290
XP_002934240 250 HDPYIVIEPHHWPPYIEMLLRYGIALRHPEDPNRIRLEAFhQ 291
NP_001243594 235 HDPYVTIDDTFWPPYTEMLLRNGIAMRHPEDCNKIRLENF-F 275
XP_001628227 238 HDPFMQLQPHHWPPYVELLLRCGLVLRHNQDSNQIKLESF-N 278
XP_005997501 250 HDPYITIDDSYWPPYIEFLLRYGIALRHPEDPHRIRLEAFhQ 291
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