Conserved Protein Domain Family
Augurin
?
pfam15187: Augurin 
Oesophageal cancer-related gene 4
Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.
Links
?
Statistics
?
PSSM-Id: 464552
Aligned: 11 rows
Threshold Bit Score: 173.06
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
P0CAX4        29 SKLHRILIKRDakeIEsrP-KAYISVQQSKAKEFLSGLHRTKRNVWDRSRPDVQQWIQQFMYMGYDEARLETDLSYWMDQ 107 zebrafish
Q566V9        29 SKLEKLLMKRVdrdVK--P-AAAVAVSPSKAKEFLTSLKRPKRNLWDRSRPDVQQWIQQFMYMGFDEARLETDLAYWMDQ 105 zebrafish
XP_006639220  30 NKLQKLFKKRE---AKpeP----LAVSPSKAKEFLTPLKRPKRNLWDRSRPDVQQWIQQFMYMGFDESRFETDLSYWMDH 102
XP_003794360  32 NKLKLMLQKRE---APa-PaKAKVAVHESKAKEFLTSLKRQKRQLWDRSRPEVQQWYQQFLYMGFDEAKFEDDVTYWLNR 107
XP_005037583  36 NKLKLMLQKRE---ASa-AaEPEVSVKERAAKEFLSSLRRQRRQLWDRSQPDVQQWYQQFLYLGFDEQKFEDDISYWTNL 111
Q5FVX5        19 NKLRLMLQKRE---AGe-PsKTIVSVKENKANEFLNSLKRPKRQLWDRTRPEVQQWYQQFLYMGFDEQKYEDDLSYWMSQ 94  tropical clawed...
XP_005798113  43 NRLQKILVKRNvaeAEhaPsKSSVAIPSSKAQEFLAKLSRTKRNVWDRSRPDVQQWIMQFMQMGFDEQRLEADLQYWMDH 122
3_pfamImport   1 SSLLRILKKRDvagAAsaPsRASVAVPSSKALAFLGKVSRTKRNLWDRSRPDVQQWIAQFMSMGFDEQRLETDLSYWMDQ 80 
XP_005457877  28 gHLHKILRKRDvagTGtaPsRSSVAVPSSRAKEFLAKLSRTKRNLWDRSRPDVQQWIMQFMYMGFDEQRLEADMAYWRDH 107
XP_014345149  60 NKLRLMLQKREe--------KPAIAVSETKANGFLNKLKRYKRQLWDRSQPDVQQWYQQFLYMGFDEAKFEDDVSYWMAR 131 coelacanth
CAG05806      27 sslqrILKTRD---AGdpPaRASVAVPPARAQEFLAPLSRTRRNIWDRSRPDVQQWIQQFMYLGFDEQQLEADLSYWMDH 103 spotted green p...

P0CAX4       108 ARS-ND-QG--RQHHHDENAPMSQQDPRYNRHGANVNYDYY 144 zebrafish
Q566V9       106 HRS-SD-QG--RQHHYDENAALGPRGAASYRHGANVNYDYY 142 zebrafish
XP_006639220 103 YRQ-HDyYG--YQHHYDENAPIGPRYPSSFRHGANVNYDDY 140
XP_003794360 108 DRNgHEyYGdyYQRHYDEDAAIGPRSPYSFRHGASVNYDDY 148
XP_005037583 112 GRArNEyYGgyYQHHYDEDSPIGPRNPHSFRHGAGVNYDDY 152
Q5FVX5        95 GRGgSEyYGgfHQHHYDEDAPIGPRNPYTFRHGAGVNYDDY 135 tropical clawed frog
XP_005798113 123 ARS-HD-QG--RQHHYDENAPIGPR--SSYRHGANVNYDYY 157
3_pfamImport  81 ARS-RD-QG--RQHQYDENAPIGPRDQSSYRHGADVNYDYY 117
XP_005457877 108 MRA-ND-PG--RQHHYDENAPIAPQDPSSYRHGANVNYDYY 144
XP_014345149 132 RNGgHEyYGgyYQHHYDEDAPIGPRYPHTFRHGANVNYDDY 172 coelacanth
CAG05806     104 ARA-HD-QG--RQHHYDENGPLGPR-APQFlqtrsrrqlrl 139 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap