Conserved Protein Domain Family
SET_Suv4-20
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cd19186: SET_Suv4-20 
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins
Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation.
Links
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Statistics
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PSSM-Id: 380963
Aligned: 9 rows
Threshold Bit Score: 290.125
Created: 5-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus Suv4-20h2 (4AU7) in complex with histone H4 peptide and SAH.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #   ##                            #         #########   #  #   ###
Q9W5E0        249 DSGFAIEACYRYTLEeqrGAKISSTKRWSKNDKIEcLVGCIAELteAEEAALLhsGKNDFSVMYSCRKNCAQLWLGPAAY 328  fruit fly
OQR71422      120 ESGFEILACDRYSMEghmGARLCATRRWQKNDKIPaLVGCIAELsaLEERQMLvaGRNDFSVMYSTRKNCAQLWLGPAAF 199  Tropilaelaps ...
XP_002128107  123 ECGFSIQPCNRYTLEd-gGAKIVSTRDWCKNDKMNlLVGCIAELtkDDESSLLvpGRNDFSVMFSTRKNCAQLWLGPASF 201  Ciona intesti...
ELT91903      120 ASGFEIQPCHRYSMEgqvGGKICATKKWMKGEKITkLVGCIGELsaEEEAQLLrpGVNDYSVMYSCRKNCAQLWLGPAAF 199  Capitella teleta
XP_013390357  111 QAGFEIMACHRYSAEgemGGKLVATRKWKKQEKIKmLVGCIAELteEEEAQILrpGENDFSVMYSCRKNCAQLWLGPAAY 190  Lingula anatina
EFX69374      116 SAGFTIQACYRYSMEgqkGAKLCTTKKWYKNEQITlLMGCIAELspDEEAQLLhpGKNDFSVMYSCRKNCAQLWLGPAAF 195  common water ...
ESO95440      109 RAGFRLMPCHRYSSEgqvGGKICTTKQWKRNDKIPmLVGCIAELtpAEEATYLrpGKNDFSVMFSCRKNCAQLWLGPAAF 188  owl limpet
XP_002732220  115 ESGFEVKSCCRYSLEg-qGAKIVSTKQWEKNEKISlLVGCISELtpLEENQLLraGENDFSVMYSTRKNCAQLWLGPASF 193  Saccoglossus ...
XP_011661791  118 DAGFEIKPCYRYSLEg-eGGKIVTTCHWSKHEKIDnLVGCIAELteFEENTFLksGENDFSIMFSMRKNCAQLWLGPAAF 196  purple sea ur...

Feature 1         ###       # #                       #  ###      ###           
Q9W5E0        329 INHDCRANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAF 390  fruit fly
OQR71422      200 INHDCRANCRFVSTGRESACVKVLRDIEAGEEITCFYGEDFFGDANSLCECHTCERRAAGAF 261  Tropilaelaps mercedesae
XP_002128107  202 INHDCRPNCCFVSTGRDTACVRVLRDILPGEEITCFYGESFFGDKNCFCECETCERRKTGAY 263  Ciona intestinalis
ELT91903      200 INHDCRSNCKFVSTGRDTACLQVLLDIRVGQEITCYYGDDFFGEGNCYCECETCERQLTGAF 261  Capitella teleta
XP_013390357  191 LNHDCKANCKFVSTGRDTACVQTLRNIDPGEEITCFYGEDFFGDNNCLCECETCERLQQGAF 252  Lingula anatina
EFX69374      196 INHDCRSNCKFVATGRGTACVRILRDIEAGEEITCFYGEDFFGDNNCFCECETCERRGTGAF 257  common water flea
ESO95440      189 INHDCRPNCKFVSTGRDTACVKALRDIEEGEEITCLYGEDFFGDKNSYCECETCERRQMGAY 250  owl limpet
XP_002732220  194 INHDCRPNCKFVSTGRDTACVQVLRDIEPEEEITCFYGDGFFGEDNCYCECETCERRKTGAF 255  Saccoglossus kowalevskii
XP_011661791  197 INHDCRPNCKFVATGRDTACVQILRDIEPEEEITCYYGEDFFGENNCYCECETCERRQSGAF 258  purple sea urchin

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