Conserved Protein Domain Family
PTS_2-RNA
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pfam01885: PTS_2-RNA (this model, PSSM-Id:396455 is obsolete and has been replaced by 460371)
RNA 2'-phosphotransferase, Tpt1 / KptA family
Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.
Links
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Statistics
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PSSM-Id: 396455
Aligned: 231 rows
Threshold Bit Score: 112.243
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5KHE9              7 DPDVRNSKTLAYILRHGAEKEGLYIRSDGFIKLA--DVLArpKL-----KG-----VDEPTILHLVQTNAKKRFElfwgy 74  Cryptococc...
jgi:Halxa_1867     36 ERRHRLSKFMSGALRHFPSDAGIDLDERGWAAYE--DLVA--AV-----ERky-dwADERHVAEVIATDPKGRFErtsgn 105 Halopiger ...
WP_012941746       35 ERRRRLSKFVSGALRHFPEDVGLELDAHGWTDYE--ALAG--AV-----EAky-dwAEPCHVAAVIATDPKGRFErtdas 104 Haloterrig...
Q5UXB8             33 ARRRQLSKFVSGALRHFPEDAGIEVDKAGWTGFD--ALRV--AV-----ERqy-dwADAAALAGVIATDPKGRFErtgvg 102 Haloarcula...
WP_015325725       30 DREERLGKFVSGALRHFPEDVGLKMDHHGWVSLG--HLLD--VL-----TEry-rwGSKERLIALVTSDRKHRYEid--- 96  Methanomet...
Q12V71             37 EREERLGRFISGALRHFPDDVGLTMDEQGWVNMD--LLCD--IM-----DRry-kwATRERLISLIESDLKTRYEik--- 103 Methanococ...
HusnBIG:Mpsy_1792  30 DREERLGRFISGALRHFPEDVGLEMDQQGWVDMD--VLCE--IM-----MKry-kwGTMERLVSLVESDMKGRYEid--- 96  Methanolob...
Q8X261             33 RRRLALSKLLSGILRHFPEEVKVKLDDEGFTDCDvhELAE--RIkkywkNReyyrwLTGEHIIAVVETCPKGRFEid--- 107 Methanopyr...
jgi:Igag_0628      37 SRRESLSKLMSFLLRHDPESIGLKMDSSGWVYID--DLVD--GIrnrwrNShlyrwVEKEHVIAIAMLDPKGRFEic--- 109 Ignisphaer...
A2BMI7             31 EQRLRLSKLMTTLLRHLPHEAGLRLDPQGWVGID--ELVR--GIrerwrNRhlyqwVTRDHVIAVALLDPKGRFQldl-- 104 Hypertherm...

Q5KHE9             75 dpspprpkkkptqgktkkqlqrdretaaaaaasaavaasgtgegqekgkepdaatidiiasslastdltappsslsinst 154 Cryptococc...
jgi:Halxa_1867        --------------------------------------------------------------------------------     Halopiger ...
WP_012941746      105 gt------------------------------------------------------------------------------ 106 Haloterrig...
Q5UXB8            103 ne------------------------------------------------------------------------------ 104 Haloarcula...
WP_015325725          --------------------------------------------------------------------------------     Methanomet...
Q12V71                --------------------------------------------------------------------------------     Methanococ...
HusnBIG:Mpsy_1792     --------------------------------------------------------------------------------     Methanolob...
Q8X261                --------------------------------------------------------------------------------     Methanopyr...
jgi:Igag_0628         --------------------------------------------------------------------------------     Ignisphaer...
A2BMI7                --------------------------------------------------------------------------------     Hypertherm...

Q5KHE9            155 apapaqsstsvdppelplislpdphtsasdsdanasansdnpkgeYFIRATQGHSiqlestahL--EQVkddEEGkrkvg 232 Cryptococc...
jgi:Halxa_1867    106 -----------------------------------------dgernRVRAAYGHSvd----vdL--EPt---AAPvp--d 133 Halopiger ...
WP_012941746      107 ---------------------------------------ddgagnGLVRASYGHSvd----vdL--GPt---DEPvp--d 136 Haloterrig...
Q5UXB8            105 --------------------------------------agittagGRVRAAYGHSvd----vtL--DGt---DDPvp--a 135 Haloarcula...
WP_015325725       97 --------------------------------------------gKHIRAKYGHSvd----veLesDYp---ENKl---p 122 Methanomet...
Q12V71            104 --------------------------------------------gSKIRARYGHSvn----veL--DYl---ETEl---p 127 Methanococ...
HusnBIG:Mpsy_1792  97 --------------------------------------------gSFIRARYGHSve----idLisDYp---ENEl---p 122 Methanolob...
Q8X261            108 -------------------------------------------ehGRIRARYGHSrrl--svrP--TLpe-aENVk---- 135 Methanopyr...
jgi:Igag_0628     110 --------------------------------------------gDRIRARYGHSknl--dieI--DYpr-dIETk---- 136 Ignisphaer...
A2BMI7            105 -------------------------------------------arGRIRAAYGHTvr----veL--GYRplsMDElp--d 133 Hypertherm...

Q5KHE9            233 LMVHGTRWELWDTLKEQGLQKMTRQHIHLAPGF-----SGpitPRP-NSTLYIYLDLSKLVAAGIPVYVSANGVVLTPG 305 Cryptococcu...
jgi:Halxa_1867    134 ELYHGTAPENLEPIREEGLKPMSRQQVHLSESReaarqVG---QRHaADPVVLVVDAAAMLADGHRITKRGEETYTTDa 209 Halopiger x...
WP_012941746      137 ELYHGTAPATLASIREDGLRPMSRQQVHLSGSReaarrVG---QRHaNDPVVLVVDATAMLADDQRITKRGRETYTTDa 212 Haloterrige...
Q5UXB8            136 TLYHGTAPRNVDSIREAGLKPMSRQTVHLSESAaaareVG---RRHaADPVVFVVDATAMQSDDRRIVKRGTETYTTDr 211 Haloarcula ...
WP_015325725      123 SLYYGVSQEEVDMLLESGIKPIRQTYVHLSTSYersveAA---LVHtDNPVILEIDADSAQNDGILVITANQDIALARs 198 Methanometh...
Q12V71            128 YLYYGVSQEEVDMLLDTGIAPMRQRYVHLSTSYgkaieSA---SVHtENPVVLEVDVDEAQNNGLHFMLVNDDIVLTDG 203 Methanococc...
HusnBIG:Mpsy_1792 123 YLYYGVSQEEADMLLENGITPVRQCYVHLSTSLekamqAA---SIHtDNPVIFEIDAASAQEDGIDIVVVNEDIVLAKs 198 Methanolobu...
Q8X261            136 ELYHGTARENLESILQHGIKPMGRRAVHLTDDErealiTA---LRHtRNPVILVVDAERLRRHGLVPRKAGKNVYVVEG 211 Methanopyru...
jgi:Igag_0628     137 ILYHGTAREFIDRISIEGLKPMNRHYVHLTIDMvdaciVG---ERHsGNPVVLKIDADCVRSHGIDIYIASKSIRLAKh 212 Ignisphaera...
A2BMI7            134 KLYHGTVAENLASILSEGLKPMRRLMVHMTTDYssaveTG---RRHgPNVVVLVIDPRCLAKHGIPVYRASDTIYLAPs 209 Hyperthermu...
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