1DHP,1O5K


Conserved Protein Domain Family
DHDPS
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cd00950: DHDPS 
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Dihydrodipicolinate synthase (DHDPS)
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis. It catalyzes the aldol condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a Schiff base formation between pyruvate and a lysine residue. The functional enzyme is a homotetramer consisting of a dimer of dimers. DHDPS is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways.
Links
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Statistics
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PSSM-Id: 188637
Aligned: 85 rows
Threshold Bit Score: 268.593
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  ##                                   
1DHP_A        2 FTGSIVAIVTPMDEkg-nVCRASLKKLIDYHVAsGTSAIVSVGTTGESATLNHDEHADVVMMTLDLad---grIPVIAGT 77  Escherichia coli
1O5K_A       14 FRGVGTAIVTPFKNg--eLDLESYERLVRYQLEnGVNALIVLGTTGESPTVNEDEREKLVSRTLEIvd---gkIPVIVGA 88  Thermotoga maritima
P26259       80 RLRLITAVKTPYLPdg-rFDLEAYDSLINMQIEgGAEGVIVGGTTGEGHLMSWDEHIMLIGHTVNCfg---srIKVIGNT 155 maize
AAF44718     47 SLRVITAVKTPYLPdg-rFDLEAYDSLINMQIEgGAEGVIVGGTTGEGHLMSWDEHIMLIGHTVNCfg---tkIKVVGNT 122 rice
NP_774022    22 LHGLWLPLVTPFRDg--kLDETSLRRLTRHYCGqAVDGFILGATSGEGMTLRDAELERLVAIVRDEmaagrrtLPICLGM 99  Bradyrhizobium j...
AAO65783     15 FNGLYVPLVTPFTDdl-rLAPEALARLADEALSaGASGLVALGTTAEAATLTAEERETVIRVCSAAcra--hgAPLIVGV 91  Streptomyces cin...
Q9LZX6       65 SLRVITAIKTPYLPdg-rFDLQAYDDLVNTQIEnGAEGVIVGGTTGEGQLMSWDEHIMLIGHTVNCfg---grIKVIGNT 140 thale cress
NP_946251    12 PRGLWLPLITPFRDg--eLDAASLRRLIAHYARaPLDGLILGATTGEGLTLDEAELERLVMLTADAlaasdrkLPVYLGL 89  Rhodopseudomonas...
NP_966530     3 STFLWTACVTPFNCngdsIDYSSLQRLLTMQVK-AENGVVLLGSTGESLSLTDSEKRTLVEFVCKLkl----nTEIIIGV 77  Wolbachia endosy...
ZP_00273011  12 VDGLWLPMVTPLHHg--qVDFDGVQRLAAHYADaGVDGLIVLGTTGEGGLLTDVERLQVAAATLEAvq---gtVPVIAGV 86  Ralstonia metall...

Feature 1                                                               #    #                  
1DHP_A       78 GANATaEAISLTQRFNDs-GIVGCLTVTPYYNRPSQEGLYQHFKAIAehtdLPQILYNVPSRTgCDLLPETVGRLAkv-k 155 Escherichia coli
1O5K_A       89 GTNSTeKTLKLVKQAEKl-GANGVLVVTPYYNKPTQEGLYQHYKYISertdLGIVVYNVPGRTgVNVLPETAARIAadlk 167 Thermotoga maritima
P26259      156 GSNSTrEAVHATEQGFAv-GMHAALHINPYYGKTSAEGMISHFEAVLp--mGPTIIYNVPSRSaQDIPPEVILAISgy-t 231 maize
AAF44718    123 GSNSTrEAIHATEQGFAv-GMHAALHINPYYGKTSVEGLISHFEAVLp--mGPTIIYNVPSRDwQDIPPPVIEAVSsy-t 198 rice
NP_774022   100 SGADTsRLKERLDETADw-PIDGYLIASPYYVRPSQRGLLAHFEALAdhaaWPLALYNIPYRCaVNITNQTMLRLAeh-p 177 Bradyrhizobium j...
AAO65783     92 GTNDTaTAITALRELAArgDVAAALVPAPPYIRPGEAGTLAHFAALAehggLPLVVYDIPYRTgQTLGAGTITALGrl-p 170 Streptomyces cin...
Q9LZX6      141 GSNSTrEAIHATEQGFAm-GMHGALHINPYYGKTSIEGMNAHFQTVLh--mGPTIIYNVPGRTcQDIPPQVIFKLSqn-p 216 thale cress
NP_946251    90 SGSDTrKLVKTLARTAHw-PIDGVLIACPYYTRPSQRGLVLHFEAAAdataRPILIYNIPYRTgVNLQNEAMLRLAer-a 167 Rhodopseudomonas...
NP_966530    78 PGVNLyQTLEWLDFCKGm-PIHGYLMTTPIYAKPGIMGQTLWFEKLLekahVPVMFYNIPSRAgINLHAETVRNLSsh-e 155 Wolbachia endosy...
ZP_00273011  87 GGVAThAVCEQVRRLERl-DLAGYLVPPPYYLRVSDEGIAWHLRSVAshtaRPLMLYNVPKRTgCTISPDLTWRLAah-p 164 Ralstonia metall...

Feature 1            #                           #  #                                           
1DHP_A      156 NIIGIKEAtgNLTRVNQIKelv---sddFVLLSGD-DASALDFMQLGGhGVISVTANVAARDMAQMCKlaaeghfaeARV 231 Escherichia coli
1O5K_A      168 NVVGIXEAnpDIDQIDRTVsltkqarsdFMVWSGN-DDRTFYLLCAGGdGVISVVSNVAPKQMVELCAeyfsgnlekSRE 246 Thermotoga maritima
P26259      232 NMAGVKECv-GHERVKHYAdk------gITIWSGNdDECHDSKWKHGAtGVISVTSNLVPGLMHSLMYkg------eNAT 298 maize
AAF44718    199 NMAGVKECv-GHERVKCYAdr------gISIWSGNdDECHESRWKYGAtGVISVASNLIPGLMHSLMYeg------eNAA 265 rice
NP_774022   178 NIVGLKDCgaSREQSIALLrdr---pdgFRVLTGE-DANYLEALTDGAdGGIVLSAHVETATFAAVYAelkrgnrdaAQA 253 Bradyrhizobium j...
AAO65783    171 EVVGIKHAtgSIDPTTMELldsp--lpgFAVLGGD-DIVLSPLVAAGAhGGIVASANLRTADYAEMIAlwrrgsaapARA 247 Streptomyces cin...
Q9LZX6      217 NMAGVKECv-GNNRVEEYTek------gIVVWSGNdDQCHDSRWDHGAtGVISVTSNLVPGLMRKLMFeg------rNSA 283 thale cress
NP_946251   168 NIVGVKDCcaDPAQTAELLrlr---ppgFAVLTGE-DALAFDALSRGCdGAILASAHLETEAFAAMMHrlqagdrlgGAT 243 Rhodopseudomonas...
NP_966530   156 KFWAIKDSsgTVDTLAQYKkva----pnIEVFCGD-DNMISDMAAYGAaGLVSVASNVWPYVAHEYVKkcl----ngRNP 226 Wolbachia endosy...
ZP_00273011 165 QIVALKECdaAGMRALAGQd-------rLDVFCGD-DAAMLDHLLRGGaGIVPASAHIRPDLFVRLIQlartgreeaARA 236 Ralstonia metall...

Feature 1                                                              
1DHP_A      232 INQRLMPLHNKLFVEpNPIPVKWACKELGlvaTDTLRLPMtpITDSGRETVRAAL 286 Escherichia coli
1O5K_A      247 VHRKLRPLMKALFVEtNPIPVKAALNLMGf-iENELRLPLvpASEKTVELLRNVL 300 Thermotoga maritima
P26259      299 LNEKLSPLMKWLFCQpNPIALNTALAQLGv-aRPVFRLPYvpLPLEKRAEFVRIV 352 maize
AAF44718    266 LNDKLLPLMKWLFCQpNPIALNTALAQLGv-aRPVFRLPYvpLPLEKRVEFVRIV 319 rice
NP_774022   254 RWQEVAELTRLLFTEpSPAPAKHWLWRSGlidSPEVRLPMveVSSELAATIDREI 308 Bradyrhizobium japonicum USDA 110
AAO65783    248 LGADLARLSAALFTEpNPTVIKGVLHAQNripSPAVRMPLlaASADSVRRAAPLA 302 Streptomyces cinnamonensis
Q9LZX6      284 LNAKLLPLMDWLFQEpNPIGVNTALAQLGv-aRPVFRLPYvpLPLSKRIEFVKLV 337 thale cress
NP_946251   244 EWQRLADLPKLLFAEpSPAPVKYALWRRGlidSPEVRLPMtpVSPTLAAAIDARM 298 Rhodopseudomonas palustris CGA009
NP_966530   227 QADIWQQACEALFIAsNPIPTKALLHDIGlieHQTVRLPLstEDLPSVEKLRQVN 281 Wolbachia endosymbiont of Drosophila mela...
ZP_00273011 237 LFRQLSPLIGMLFDEpNPAPVKAALALCGl-aRPEVRRPLmpASKSLVARLDAAI 290 Ralstonia metallidurans CH34

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