1UHR,4HBM,1V31


Conserved Protein Domain Family
SWIB

?
pfam02201: SWIB 
SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
?
PSSM-Id: 460488
Aligned: 334 rows
Threshold Bit Score: 45.9367
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1UHR_A        10 PQFKLDPRLARLLG-----IHt--qTRPVIIQALWQYIKTHKLQDPHEREF--VLC-DKYLQQIFES-QRMKFSEIPQRL 78  house mouse
XP_004997096 176 ARFKLNAAFARVLH-----LRs--aPELDVNKHLWTYIREHNLQDERDRHV--IRC-DQPLQSAF-GvGTFKVSEMASLV 244
XP_005849826 263 vQYRLSSALAGAL------ALrglhSMPFVMQMLWGYIKAKQLYEPSDKGSvcVRC-DERLRPLF-GtDSVELGKMAEAL 334
ELK03330      25 kqVRPKLPLLKILQaagaqGEi--fTVTEVMHYLGQYITMKQLYDPREQHM--VYCgGDLLGELLG----CQSFSVKDPS 96 
XP_016119088  19 klVRPKVQLKSLLEdagadKDv--fTMKEVMFYLGKYIMSKELYDKQQQHI--VHCgEDALGAVLG----VKSFSVKEPR 90 
XP_015208268  23 klVKPKTKLHALLQhagadKDi--fTMKEIMFYLGQYIMDKQLYDKKQQHI--VHCtNDLLGDVLG----VNSFSVKEPR 94 
4HBM_A        21 tlVRPKPLLLKLLKsvgaqKDt--yTMKEVLFYLGQYIMTKRLYDEKQQHI--VYCsNDLLGDLFG----VPSFSVKEHR 92  human
XP_011271235 214 ikliTSNELSSLLG-----VNe--lTQHDAVYSIWQYIQFNNLQAPEDKRI--INC-DENLSKLFNV-PRFNFRDLIELL 282
XP_002901968 298 QLYRLSPALSNMLG-----KSe--lTRPAAIKEFWAYVKKHELQDPKDGRM--IHP-NAEMMNVFKVe-EIKFTQVMGLV 366
KAE9199220    26 KLYKLSPSLSHLLG-----KSe--lTRPAAIKEFWAYVKEHELQDPKDGRR--IHP-NQEMKDVFSVd-EIGFTQVMGLL 94  Phytophthora fr...
1UHR_A        79 HALL 82  house mouse
XP_004997096 245 Rtcl 248
XP_005849826 335 KQHL 338
ELK03330      97 PLYa 100
XP_016119088  91 ALFa 94 
XP_015208268  95 NLYA 98 
4HBM_A        93 KIYT 96  human
XP_011271235 283 SKHL 286
XP_002901968 367 SKHL 370
KAE9199220    95 SKHL 98  Phytophthora fragariae
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap