Conserved Protein Domain Family
FH_FOXN2
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cd20058: FH_FOXN2 
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410832
Aligned: 5 rows
Threshold Bit Score: 182.154
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                 ##  #                  ## ##  #      #          ### #   
P32314       111 SKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKvNGKGSLWCVD 190 human
Q66J77       107 SKPPYSFSLLIYMAIEHSPNKCLPVKDIYSWILDRFPYFSTAPTGWKNSVRHNLSLNKYFQKVERSHGKvNGKGSLWCVD 186 African clawed ...
XP_005999348 110 SKPPYSFSLLIYMAIEDSPNKCLPVKEIYSWILEHFPYFVSAPTGWKNSVRHNLSLNKCFRKVERSHGKaNGKGSLWCVD 189 coelacanth
NP_001034373 111 SKPPYSFSLLIYMAIEHSPNKSLPVKEIYSWILERFPYFATAPTGWKNSVRHNLSLNKCFRKVERSHGKvNGKGSLWCVD 190 chicken
AAH92937     120 SKPPFSFSLLIYMAIEHSPSKSLPVKDIYGWILKHFPYFSSAPTGWKNSVRHNLSLNKCFRKVERSIGKtNGKGSLWCVH 199 zebrafish

Feature 1          
P32314       191 PE 192 human
Q66J77       187 PE 188 African clawed frog
XP_005999348 190 PE 191 coelacanth
NP_001034373 191 PE 192 chicken
AAH92937     200 PE 201 zebrafish

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