6SN1


Conserved Protein Domain Family
Mat89Bb

?
pfam10221: Mat89Bb 
Cell cycle and development regulator Mat89Bb
This is entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. It is a component of INT (Integrator) complex, being involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Mat89Bb is also required for the correct dynein-dynactin perinuclear localization. Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.
Statistics
?
PSSM-Id: 463006
Aligned: 19 rows
Threshold Bit Score: 781.933
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6SN1_A         61 FSESHKTVFVVDHCPYMAESCRQHVEFDML--VKNRTqgi---iplAPISKSLWTCSVESSMEYCRIMYDIFPFK-KLVN 134 
XP_002429921    7 TQTNHKTVFVIDHTPYFGISCEDLMEFD-L--NKTRGlnv---iplAPVSKSLWTCGIEAAVEYCRIVWDLFPEG-KLIR 79  
EFN67780        2 YPANHKTIFVLDHTPYFGISTECPLEFD-F--LKSRGqnl---iplAPVCKSLWTTSVEASLEYCRIVWDLFPTG-KLIR 74  
XP_008203005    2 YPANHKTVFVLDHTPYFGIPSENDIDFD-F--VKSRTptpantlplPKISKSLWTTSIETSMEYCRIAWDLFPTD-KLIR 77  
EFA08805       10 fPSNHKTVFVLDHTPYFGISCESPIELE-F--LKARTpgf---ipmTPICKSLWTSSVESAIEYCRIVWDLFPQG-KLVR 82  
EDS33153        2 AEFNHKTVFVLDHTPYFGISCEAPIDCD-F--IKSKip-------iPAISKSLWTASVEASVEYCRIAWDLFPGG-KLIR 70  
XP_003108191  944 EQLKMKTVIMLDRSAKFIDDSNETFDIAIRegPKQKK---------VEFKKDIWTWCMEGLFEMQRVLADVYPLGnIPIR 1014
O44500          2 EQRDMKTVFLLDRSAKFVENCNETFDVTIRegPKQKK---------LQFEKTIWTWCLEGIFEMHRILSDVYPRGtLQLR 72   Caenorhabditi...
CAP22953        2 EQRDMKTVVVLDRNADFAEETNETFDIAIRegVKQKK---------LEIKKDYWTWCVESVFEMHRILSDVYPHGsLQIR 72  
XP_307882       2 NEINHKTVFVLDHTPYFGISCESPIDCD-F--IKSKva-------vPPISKSLWTCAVEASVEYCRIAYDLFPVG-KLIR 70   Anopheles gam...
6SN1_A        135 FIVSDSGAHVLN-SWTQEDQNLQELMAALAAVGPPNPRa--dPECCSILHGLVAAVETLCKITEYQ--HEARtll----- 204 
XP_002429921   80 FIASDSTAHHFN-SWEQSQQSISYILNSSAYLGTPPRAhq-qG-DYSVIHGLRAAVEALTECSEIQ--HIKRtsl----- 149 
EFN67780       75 FVVTDRAAYVLN-SWSPLQQNLNHIMNGTAILGVPPKTpd-pGEDYSVIHGLRVAIETLNECSEIQ--HEKRtsl----- 145 
XP_008203005   78 FVVSDHSAHILN-TWNPSQQTLAHIMNGMAIIGVPPRNhq-qGVDFSVIHGLRVAIEALTECSETQ--QEIKarg----- 148 
EFA08805       83 FIASDTVAHILN-TWSPSQQNLSHVMNAMSLIGVPPPHainrNLEYTVLHGLRAAIEALSDCTDIQvkKSQNqtf----- 156 
EDS33153       71 FVVSDTAAHIVN-TWNASTQSLTHVMNAMSMVGIPPRQt--qANDYSVIHGLRAAIEALAEPTDLQ--KEQLaan----- 140 
XP_003108191 1015 FAVADYMGKMLEtEWKNKLLSREELGKIVVEIGRPSES----NTDITPVGGLTMAIEALAVETSEQkeYNYDirynlnkr 1090
O44500         73 FALADFMGKMLDtQWTDGFLTREELGELIETVSRPSEA----NTDITPIGGLTMAIEALAVQSPEQrnYNYDvrysankr 148  Caenorhabditi...
CAP22953       73 IALADYLARMLDaEWTTDLITRAELGELIEKTGKPCPE----DIDIDSTCGWQMAIEALAVESPEQieHNFNarfnikkr 148 
XP_307882      71 FVVSDTAAHIVN-TWNTNTQSLTHILNAMSMVGVPPRQt--qASDYSVIHGLRAAIEALAEPTEFQ--KEQLavha---- 141  Anopheles gam...
6SN1_A        205 ----------------menAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSD--HLMQIQKCELVLIHT 266 
XP_002429921  150 ----------------menAMKLDNKCRVICITSTRDNASMKSLQEIFLKVLTQQNKVATATD--HLIAVHHCHLVIINI 211 
EFN67780      146 ----------------nenTTKLVNRGRVICITSARDNSNMKSLENIFLNELAQENKTALASD--HLIPIDYCHLVILNI 207 
XP_008203005  149 ----------------gepANKLINRGRVICITSARDDMNMKSLENIFLNQLIQQNKQAANVDanNLIPIHNCHLVILNI 212 
EFA08805      157 ----------------gdvQTKLINRCRVICITSARDNDSMKRLEEIFLSVLQQQNKVAAGSD--RLLTIDHCHLVIINT 218 
EDS33153      141 -------------------eqvTYNLGRVICITSARDDASMKSLEDIFRTVLMQQNTISASHK--EYLKIDQCHLVIINL 199 
XP_003108191 1091 tsqnsevvrvtnelkntppFSTVENKGNLILFTRLKTEDEMEALQKEVASLVVSRNSIANAPSnkTFCPITALRVFIVNY 1170
O44500        149 taqnsevirvtrelrglppLPTVQNAGNLIMYTRLNTQEEMEQLQTEIVELVVSRNKIADAPSnkTFCPITSLRLFIVNY 228  Caenorhabditi...
CAP22953      149 sdqnsevarvtkelndepaSPAIENNGNLIIYTRYKTDEEMMEAKEEIASLVSSVNAIASSESnrTFCPITSLRVFIVNF 228 
XP_307882     142 ----------------ksdCFKLVNRGRVICITSARDDASMKSLEDIFRTVLVQQNAISAGHK--EYINIDQCHLVIINL 203  Anopheles gam...
6SN1_A        267 YPVGEDSLVSDRSKKE--LSPVLTSEVHSVRAGRhLATKLNILVQQHFDLASTTITNIPMKEEQHAntSANYDVELLHHK 344 
XP_002429921  212 FPNNAESNVTSQPLNE--LSPLLSAEVHSVCAGKgLNNKLSHLILGHYGLASTTVTGIPMKEEQNAssSANYDVEIFHHA 289 
EFN67780      208 YPNNIESQVTSQGPRE--ISPLLTVEVHSIKASA-LHSKLSHLILSHYDLASTTVTGIPMKEEQNAssSANYDVEIFHSS 284 
XP_008203005  213 SPMSIESQVTSQNLRE--VSPLLSMEVHSLKAPV-LHSKLSHLILSHYDLASTTVTGIPMKEEQNAssSANYDVEIFHSH 289 
EFA08805      219 FPVNIESQVNNHPPKN--LSTILTTEVHSIKAPL-ISNKLSTLILEHYNLASTTVTGIPMKEEQNAssSANYDVEIYHAS 295 
EDS33153      200 YPSNLESMVNNRGLID--ISPILKSEIHSNKAHL-ISNKLTHLILPHFDLASTTVTGIPMKEEQNAssSANYDVEIFHGR 276 
XP_003108191 1171 YAVGEDCTVKTHPLLEhpELPLLKFWVISRKVTD-MCVAIHSLLVASFDLGSTTVTKIPMKEDNRG--STNYDVELFHSG 1247
O44500        229 YATGDECTVKTHSLQAhpDLPLLKIWVISRKAAD-MCDAIHSLLVDAFDLGSTTVTKIPMKEDNRG--SSNYDVELFHSG 305  Caenorhabditi...
CAP22953      229 YGADEECAVKTHSLEEypDLPLLKFWVISRKASD-MCVAIHSVLVAAFDLSSTTVTKIPMKEDNRG--STNYDVELFHSS 305 
XP_307882     204 YPANMESMVSNRALIE--ISPILLSEIHSNKANT-ISNKLTHLILPHFDLASTTVTGIPMKEEQNAssSANYDVEIFHGR 280  Anopheles gam...
6SN1_A        345 DAHVDFLKSGdSHLGggS--R---EGSFKETITLKWC-TPR-TNNIe---------------LHYCTGAYRISPVDVNSR 402 
XP_002429921  290 NAHADLYKTLvTDPLlmKtkK---NGTDYDTVTLKWC-TPRgSSAQe---------------MHNCTAAYRVTPVDVNSR 350 
EFN67780      285 AAHTAILKANpQDSAliKtfRrfeEGSEYETVTLKWC-TPRgCSASe---------------MQYCTAMHRITPVDVNSR 348 
XP_008203005  290 AAHLAILKGHaQDTAlvKsfRrfdEGIEYETVTLKWC-TPRgCSAGe---------------MQNCTAMHRITPVDVNSR 353 
EFA08805      296 SAHTAILKGNaLDSAaiRtiK---DGLEYETVTLKWC-TPRgCSGSe---------------LQNCTGMFRITPVDVNSR 356 
EDS33153      277 TAHSVFLG---TELAlpHsvK---DGSDYETVTLKWC-TPRsCGSSe---------------MQPCLAQCRVTPVDVTSR 334 
XP_003108191 1248 QVHTLLKEKElIAIE--SkkGradEGPTYDSIRLTWTtAPKsRWSLvrflsglkrfnlihfkFPYHGAAVPCTTAVAYSR 1325
O44500        306 KVHAMLKENNlIDTV--SkkGdsdKGVTYDTMRLTWTtAPKtKWSL----------------FPYHGAAVPCTTAQAYSR 367  Caenorhabditi...
CAP22953      306 KVHEQLKENNlIARV--SekGnanSGVTYDTMRLTWTtAPKiKWTL----------------FPYHDDAVPCTTAVAYSR 367 
XP_307882     281 TAHSVFLG---TELVlpHslK---DGSDYETVTLKWC-TPRsCGSSe---------------MQPCLAQCRVTPVDVTSR 338  Anopheles gam...
6SN1_A        403 PSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTD------- 469 
XP_002429921  351 PSSCLINFLLNGRSVMLEMPKRV------GGKTVSHLLTAHGGEIFIHALATGRSVLEDPPSISEGCGGRVTD------- 417 
EFN67780      349 PSSCLINFLLNGRSVMLEMARKT------GGKTISHLLAAHGGEIFIHTLSTARSVLEDPPSISEGCGGRVTD------- 415 
XP_008203005  354 PSSCLINFLLNGRSVMLEMARKS------GGKTISHLLASHGGEIFIHTLPTSRSVLEDPPSISEGCGGRVTD------- 420 
EFA08805      357 PSLCLINFLLNGRSVMLEMPRKA------GGKITSHLLASHGGEIFIHTLCTARSVLEDPPSISEGCGGRVTD------- 423 
EDS33153      335 PSSCLINFLLNGRSVLLEMPKKS------GGKITSHLLSAHGGEIFIHSLNTSRSCLEEPPSISEGGGGRVTD------- 401 
XP_003108191 1326 PSACLTQFVRDGRCVMLDSEKTSefgmnmPEKLVSHILIANRGRIFIQEIDFMQKKFDKSRVVRQVKFPKATYgpkdpin 1405
O44500        368 PSACLTQFVRDGRCVMLDSEKTTelgmnmHEKLVSHLLIANRGRIFIQEIDFMQKKAD--RIAGKLKRPRVLHapedpin 445  Caenorhabditi...
CAP22953      368 PSACLTQFVRDGRCVMLDSEKTSllgmnmPDKLVSHILIANRGRMYILDIDFMQKKMRRLQRLRELKPPRRVRirdpinv 447 
XP_307882     339 PSSCLINFLLSGRSVLLEMPKKS------GGKITSHLLSAHGGEIFIHSLNTARSCLEDPPSISEGGGGRVTD------- 405  Anopheles gam...
6SN1_A        470 -------YRITDFgEFMRENRLTPFldpRYKI--DGSLEVPLERAKDQLEKHTRYWPMIISQTTIF---NMQAVV-PLAS 536 
XP_002429921  418 -------YRITDFgLLMQNNTLIPLq-gKLSEnrSDNINLPINCMKNKLDRQTKYWPITISGTFIM---NLRQYIdPLPQ 486 
EFN67780      416 -------YRITDFgFLMRNNILVPL---KRTS--NSNDDGTVEKMRSRLERHTKYWPMTISSTLMF---NLKQVIdPLAE 480 
XP_008203005  421 -------YRITDFaALMRANTLVPL---KRKP---DDTDGPVERMRPRFERFTKYWPITLTSTMIF---NVRSIIdPLPD 484 
EFA08805      424 -------YRITDFgLLIKQNTLVPI---KAGF--VDEGNRPIQKMKTRLNRHTKYWPLTISSTLIF---NLKGYIdPLPS 488 
EDS33153      402 -------YRINDFgQLMQLHRIVPL---KVVP--ERSPDENLLKLRTKLAKNSRYWPITLGGTILY---NVRQFVePILL 466 
XP_003108191 1406 lnqlkhtYKQMEL-KLVAKNRM-NEdmtEKRE--KKWKALKNSNIEKRFSRISKNIPAYADDTFIFq-pNVTNKLePLIT 1480
O44500        446 mnqlrhtYKQLEL-RFVAKNRM-DDnltEKET--EKWTGLKNSDLKKRFQRISKNIPCFAADTFIFn-eKVTPKLePLIS 520  Caenorhabditi...
CAP22953      448 -hqlkhtFKQIEF-KKVGKNFLEDDnvaEQKG--KQRKRLKTLDIQKRLRCITKNIPMYQEDTFIFysdEVTKKLePLVT 523 
XP_307882     406 -------YRIKDFgALMQQHRLVPL---KPLP--ERQPDEHLQKMRGKLARNSRYWPLTLGRTVLY---NVRHFVePLLL 470  Anopheles gam...
6SN1_A        537 VIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTV--G----TRGKGPk-rDEQYRIMWNELETLVRAHINNsEKHQR 609 
XP_002429921  487 LLTKEELTSDEVAQCKQVISSLASLETKHEPLIQPNT--G----VRGKGQk-rEEQYKLMWNELEKFVRTHCRS-DQHNK 558 
EFN67780      481 LMVKEELTTDEVLQCKQVIFSVLGLEAKHETLPLPNIggG----RGGKGGvrrEEHYRLLWDEMETFLKHHANNsAAHTE 556 
XP_008203005  485 LILKEELTKEEVVQCKQIIFSLLALEAKHETLPLPSLgcG----RGGKSGk-rDEHYMLLWRELETFLEIYSTTsSAHLE 559 
EFA08805      489 IITKEKITEEEVYQCRRIIFNLISLESKNESLYSLNA--G----QRVKGQk-rEDQYKAMWNELETLLKKNLHT-ADHRS 560 
EDS33153      467 RTQKPELTDDDVLQCQKIVYNLATLEGRQESLALPNM--G----HRLKGNk-rEEQYRLLWAELEMVVSFSGTS-AGHKA 538 
XP_003108191 1481 VITKKKLTPADVEQCKAKIMKIHQMRALKEFIVPEEEdiElcpvEDLSDP---EEQIRVAIVELAKHLVKYVTYsDRHSQ 1557
O44500        521 LITKTTLSENDVDKCKQCIVTLYQMKNERQYVISPESdiKissvRNLKDP---DEQLRVTFVELAKHIMKYVTFsEKHKE 597  Caenorhabditi...
CAP22953      524 KITKRRLTPADVQQCNSKIMKLHQMRALKEFIVPEDAdiDaclvEDLSDP---EEQMRVAIVELAKHLMKYSNFsVRHKA 600 
XP_307882     471 LTQKPELSEEEKMLCLKSIYNLSQLEERQEVLALPNM--G----HRLKGNk-kEEQYRLLWSELETIVNCNGAS-PAHKA 542  Anopheles gam...
6SN1_A        610 VLECLMACRSKPPEEE---------ERKKRGRKREDKEDKSEKavK--DYEQEKSW-QDSERLKGILERGKEElaeaeii 677 
XP_002429921  559 VLHYLLEFRNKETDNK-------------------STGDKVEL--DqaLRELDVMTsKFSETHNTDSFLTRASvir--at 615 
EFN67780      557 VLTCLLEIRNKDDK------------------------DKVEL--DqaLRELDSFG--------KEDGTARVSvir--at 600 
XP_008203005  560 VLNCLLEVRNKEDKDN----------------------NKVEL--DqaLRELDGLD--------KEDVTARATvir--at 605 
EFA08805      561 VYNCLLECHKFNFEEE-------------------KLSDKVEL--DeaLRELDHIG-----PSKSDSDAPRASvir--at 612 
EDS33153      539 VLKCIRDCRSRAPIEI---------------------SDKDE-----------------------PIDAHRASvir--at 572 
XP_003108191 1558 IYKTFMTTLGADKLLKvdaedyeavDNMFPKSPFFDGEE---------SEDSDSSDsSDFSENSDSEEAEESDgs----- 1623
O44500        598 IYKTYMTTLNVDKLLEvdldddeavDKMFVKFSFFGKSD---------------------TASKTDEDEDSSDdedeeil 656  Caenorhabditi...
CAP22953      601 VYKTFMTTMGADKLLEvdleddeaiDKMFVKRPFFMKTRGDTD--V--SSESESSDtCSSCSDEEEEEMEEDDnkegegs 676 
XP_307882     543 IVGCIRECRRMYPSAD-----------------GADPYDKTHG--Gt----aEGGVaAAAAAAAAAADAHRASvir--at 597  Anopheles gam...
6SN1_A        678 kDSPDSPE--------------------------------------PPNKKplvemdet--------------pqveksk 705 
XP_002429921  616 tDSPMSPP--------------------------------------PASKAtspllmnsrqn--------rttagisiys 649 
EFN67780      601 tDSPMSPPanv---------------------------------smPLNKQlhka-----------------------nv 624 
XP_008203005  606 tDSPMSPP--------------------------------------PCPSAslakqlh----------------skslya 631 
EFA08805      613 tDSPMSPP--------------------------------------PLTSInppvaksgt------------srsggiys 642 
EDS33153      573 tDSPMSPPhsmsa-----------------------------tstnPDSSVtallaasgsgr--------galkkgqsgp 615 
XP_003108191 1624 -eDSENTLttflnnsldrhrlps---------qkrkiskvevvkekPIQLA----------------------------- 1664
O44500        657 kSPALKKLfgyvdarderkyeel--------ygqgfkkkkpeveekPIVMA----------------------------- 699  Caenorhabditi...
CAP22953      677 gHRSRNMLkrflkyadrdgspt-----------ivdksknakldelLFELA----------------------------- 716 
XP_307882     598 tDSPMSPPhsmggstgaagasggatagggsnggtgggtgadatsssSGTSVtlavgsggvsvgllgargtmgsgkkgfgs 677  Anopheles gam...
6SN1_A        706 gPVSLLSLWSNRi---NTANSRKHQEFAGRln-sVNNRAELYQHLK 747 
XP_002429921  650 gPRTLMDLWLSKisadSKNSKDKRPDFYGRln-aSGPIATLYPNLV 694 
EFN67780      625 gSKSLLDIWLQR-----SAPKDRKPDFHGRin-sDGLKAKLYPNLK 664 
XP_008203005  632 lPRSLLDIWLQR-----SAPKDRRPDFHGRvn-sDGPRAKLYPNLK 671 
EFA08805      643 aPRTLLDIFTSQ------EKVKSRPEFSGRl--aGGAVAKLYANhk 680 
EDS33153      616 gTRSLLDILASS----ERAQSQKRIDFSGRlctaPGQVAKLYPNFG 657 
XP_003108191 1665 -KDIEINIFAKMcdmlEKKESQIRREFVGRe--aHGNKAPLYLQLM 1707
O44500        700 -KEIKVDIFSNMcdmlEVKESKIRREFVGRe--tHGNIAPLYPQLA 742  Caenorhabditis elegans
CAP22953      717 -KDIEFDLFTNVceriEKKEEGQRREFVGRe--aHGNKAPLYPQLA 759 
XP_307882     678 gGRSLLDVLAST----ERAISQKRIDFSGRlctpSGQVAKLYSHVG 719  Anopheles gambiae str. PEST
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap