pfam01080: Presenilin (this model, PSSM-Id:395857 is obsolete and has been replaced by 460052)
Presenilin
Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.