5YIT


Conserved Protein Domain Family
CoA_transf_3

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pfam02515: CoA_transf_3 
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CoA-transferase family III
CoA-transferases are found in organizms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.
Statistics
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PSSM-Id: 426810
Aligned: 48 rows
Threshold Bit Score: 255.993
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YIT_C             10 LDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP--GGEAARQITSVLPgrpPLATYFLPNN--RGKKSVTVDLTTEQA 85  Mycobacter...
Q8F1J1              6 LSGIKVIDLSLLLPGPLCSMYLGDMGAEIIKVENPr-AMDATRVMFKKAN---GAPSLYLMLN--RNKKAITLNLKKEKS 79  Leptospira...
A0DG77              2 LSQIKVLEFAGLAPTVFIGMVLADYGAQVTILS----RHDSQPQN--------------SPMN--RGKKSMTFDLKNKQD 61  Paramecium...
Q5LSR3            429 LDGLKVLDLTNVIAGPTIGSTLARFGAQVTLVQPVrpSVD-------------PWNAVVFGLHaqRGKESVLLDLRSEQG 495 Ruegeria p...
A0DKC9              2 YKQLKVLDLSRILVGPYATMLLSDLGAQVIKVESF--EGDETRKWGPPFFn--NQSTYFLSIN--RSKQSICVDLK--KG 73  Paramecium...
Q7VS14              6 LAGITVLDFSQGIAGPHGACLLGEMGAEVIKIEPP--AGDWLRGLGHRQG---GTSVLFGYFN--RGKAGVALDLKDHAQ 78  Bordetella...
jgi:Veis_4636      39 LKNVRVIDLGQYIAGPGAAMVLAELGAQVIKIEPL--AGDQARHIGR------YGESMIRAYS--RGKQSIALNLKSDAG 108
tigr:AHA_1251       4 LAGVRVLDLSRVLAGPWASQLLADLGADVVKVEAPg-RGDDTRHWGPPELv-aGEAAYFHAAN--RGKRSIALDLARD-- 77 
Q5FLY9             24 LSGILVVDFTHVLSGPTCTRMLADAGARVIHIERK--TGDDTRHMRPYISd--GSSEYFRICN--AGKESVALDLKDPKD 97  Lactobacil...
jgi:Franean1_4296  20 LEGLLVVGLEQAVAAPIATRHLADMGARVVKVENPr-GGDFARHYDGALN---GMAAHFVWVN--RGKESLTLNLTDPRG 93 
5YIT_C             86 KQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGG--NGPHGSRPGIDLVVAAEAGMTTG-M--P 160 Mycobacter...
Q8F1J1             80 REILFKLLENADILLEGFRPDGLAKMGYGYDDLKERFPKLIYCGIYGYGT--EGKYRNFAGHDVNYLSLSGVLSQ-T--G 154 Leptospira...
A0DG77             62 IEIVKHMIKDSNILIDPYRPGVLERLGLSYKICSEINPKLIYCRVTGFGQ--NSPLKEKAGHDINFISYGGVLGYcAstG 139 Paramecium...
Q5LSR3            496 QEALWRLVAEADVITMNGTDQQRDALGLTEARLNEVNPRLILVQLDAWGGprRGPKSDHLGYDDLAQAATGVMTRfG--G 573 Ruegeria p...
A0DKC9             74 SSFIKQLAQQSDVLVENFTSGVMDRLGLGYDELSKINPRLIYASVNGFG-----SNNNQPGFDYIMQAETGFMHI-T--G 145 Paramecium...
Q7VS14             79 RRQALALIDKADVLIESNRPGVMARLGLGYEQARQRNPGLVYISVTGFGQ--DGPHRDLPATDAAMQAYSGFSFG-A--G 153 Bordetella...
jgi:Veis_4636     109 REIAWRLIANSDVVIQNLRPGAVEALGLGPSAVRERFPKVIYLSISGFGD--LGPSSARPGYDIAAQAESGLMSV-T--G 183
tigr:AHA_1251      78 RETLLALVERADVVIENFKVGGLARYGLDYPSLKARRPALIYCSITGFGQ--DGPWAQRPGYDLLIQGLGGLMSI-T--G 152
Q5FLY9             98 HALAEKMIAKADVVVENFRPGVMKRLGFGPEEMVKKYPKLIFASISGFGQ--YGPWSKQAAYDTIVQAVSGLMDA-T--G 172 Lactobacil...
jgi:Franean1_4296  94 AEALERLLGRADVLIQNLAPGAAARRGLAAEQVVARHPRMVAVDISGYGE--GGPLSHKRAYDLLVQSEGGSCSV-T--G 168
5YIT_C            161 Tpe----gKPQIIPFQLVDN-ASGHVLAQA-VLAALLHRER-NGVADVVQVAMYDVAVGLQANQLMMHl-nRAASDQPKp 232 Mycobacter...
Q8F1J1            155 K-------TPQIPGYQLADI-GGGTMTALSsILAALYAREK-TGKGQKISVSMMDSSLPFLSLYGGIY---GATGKNPE- 221 Leptospira...
A0DG77            140 Sqk----rP-AIPGNVIGDFaVGGMLGVAS-ILAALINVQK-GGSGQQIDLGMAQGAAYLSQFILHQKnekLWSNGIGNn 212 Paramecium...
Q5LSR3            574 Gpe----tPEEHAHFGTIDA-LTGHCACVA-LGAALERLRV-TGKGGVARASLAAAGE-MIQAQFMYDfdgRPAFDEPSg 645 Ruegeria p...
A0DKC9            146 Eke----rEPMKVGVAIIDV-LTALNLCNG-IQGALYQRIE-TDRGCHIQTSLYESAIASLVNVSGMY---LNGQKDMHr 215 Paramecium...
Q7VS14            154 Dm-----rDPVRVRVSVVDI-VTGVYVSNA-ALAALMARHGnQGQGQYIDLSLMHGISAVQGAKYAEH---AATRGVISr 223 Bordetella...
jgi:Veis_4636     184 Epd----rLPQKVGVPIIDA-AAAHLGAQA-VLAALYGRAQ-TGVGETLRASLLEVALHLQATTWCDY---LGGAPEPTr 253
tigr:AHA_1251     153 QpdeapggGPVKVGVALVDI-LTGLYATIG-IQAALRHRER-TGEGQQIDLALLDVSVAVLANQAMNY---LATGQAPGr 226
Q5FLY9            173 Tpk----gKPTRVGTSVSDV-VAGIMGYSA-IMTALVARDR-TGKGTTVDVSMLDSTFSLMVQDLMLA---LGPHEVPHr 242 Lactobacil...
jgi:Franean1_4296 169 Epg----rP-AKAGIPIIDL-ATGMYALSS-ILAALYARRE-TGRGSAISLSLFDVVTEWMGYSLNFT---MGTGVEQQp 237
5YIT_C            233 epA----PkakrrkgvgfATQP-SDAFRTADG-YIVISAYVPKHWQKLCY-LIGRPD-LVEDQRFAEQRSrsi-nyaELT 303 Mycobacter...
Q8F1J1            222 --GgnelLs--------gKLPN-YNVYQTKEGrWVALGALEDMFFKTFLR-QTGLDKhLEELPAEEKNFS-------KWK 282 Leptospira...
A0DG77            213 v----ldG----------GTHF-YNIYQCKDGkFMSVGCLEEKFYQEFVKgLIAGGL-SQQRGQFILENQlnqaeweNLK 276 Paramecium...
Q5LSR3            646 r----evR----------GWGSfYRCYAAADG-WMFFAAPTERD-AALQR--------VPDLSDLVGKDDa------DLE 695 Ruegeria p...
A0DKC9            216 --MgnqhP----------SISP-YGTFKIKNK-YIVIGVAQDNQFQSLCK-ILNLNH-LTSDEQFKENKGrvq-nseKLK 278 Paramecium...
Q7VS14            224 ------eL----------Y-AA-IGIYPTRDG-HIALSAMRDQQVTDFIG-LAGRAD-LLADPRYATQQAryd-nqdELR 281 Bordetella...
jgi:Veis_4636     254 --IgdgqP----------NNAPaAEVVPTRDG-HIVLSAYADEHWARFCR-VMGREP-LATDPRFCTNALrvq-hrsELR 317
tigr:AHA_1251     227 --LgnghP----------NIVP-YDVYPTRDG-HLILAVGNDGQFAALAA-LLGEPG-WAQDPDFASNSArvr-qrhRLN 289
Q5FLY9            243 --IgnrhP----------DMYP-FDTFDCKDQ-PIAICCGNDHLWSLLSH-TLGHDE-WVNQPNFKTNDLrek-nwqKVK 305 Lactobacil...
jgi:Franean1_4296 238 --AgvgsP----------AVAP-YGAYPTADGqTVVLGTTNDREWQRLARtVLDRPD-LADDPAFAGNADrvr-eraRLD 302
5YIT_C            304 AELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPLFAENDLTLEVGRGA----DT--ITVIRT-----PARYASF 372 Mycobacter...
Q8F1J1            283 EILTTYFSTKTFEDLNVLFENQDSCLTPVKTIEEVIKDPVFQESGMVIEKKHPDy---GD--YFQFGA-----PFSFSET 352 Leptospira...
A0DG77            277 QEISTLFESKTRDQWEKIFDQFDACVSPVVDLEEY--ETKNYLGENVFVKRNGK--------IEVNGQ-----PIFSDY- 340 Paramecium...
Q5LSR3            696 DLLAERFAQKRVADWMRAFAGGSVGITPLGSLHGTRDAGLQRESEGEIDISKATfravRHdrHPMGRWvdlvaPNAVRPE 775 Ruegeria p...
A0DKC9            279 KIIEEALEIWDVEDLIEVMKKNKIPVGEVKSVGQCLESSHTKQLNMVMELENGE---------KAIRN-----PLSFSNI 344 Paramecium...
Q7VS14            282 ALIAAELAKQPTAHWIEAARRIDLICQPVQTYDQFRQDPQVRTYELFQDMDLGYd---MP--LPAVRM-----P-GMTAT 350 Bordetella...
jgi:Veis_4636     318 IVLRECLSSFTSEECVALLSRNQIVVGFVRSYQQVLQSADVQASGILVDALGADg---ER--YPSLAL-----PYRLGDA 387
tigr:AHA_1251     290 ALIAERLLARSSAEWSAMLEAAGVPGGPILTLDALFALEQGAVRGWVQQVQRGE----QP--LPTLAN-----PLHLSAT 358
Q5FLY9            306 NTMQAVLKTKNAAEWDKILHEAGIPAGLVLNVDKTRRLDQIIARGMVKTLPDGN---------EVLGS-----PMKYSTW 371 Lactobacil...
jgi:Franean1_4296 303 EVIIAWSKSVTLVEAQEILDNAELGNARLNGVQDVLDHPHLRERDRWQDVSTPT----GSvrALLPP------PIAAEWT 372
5YIT_C            373 RA-VVTDPP-PTaGEHN 387 Mycobacterium tuberculosis H37Rv
Q8F1J1            353 PV-TYRLDP-PShGEHN 367 Leptospira interrogans
A0DG77            341 ---QFQFKDiPKiGQHN 354 Paramecium tetraurelia
Q5LSR3            776 KTrITIPGPaPKyGQHT 792 Ruegeria pomeroyi
A0DKC9            345 NL-DYPKQA-PYlNEHR 359 Paramecium tetraurelia
Q7VS14            351 QA--SLRPP-PRlGADT 364 Bordetella pertussis
jgi:Veis_4636     388 PR-ATPPAA-PAcGADT 402
tigr:AHA_1251     359 PV-RYGRAS-PAlDGDR 373
Q5FLY9            372 NSyGLQKDA-PKlNENG 387 Lactobacillus acidophilus
jgi:Franean1_4296 373 PP----MGAvPAlGEHT 385
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