Conserved Protein Domain Family
7tmA_Retinal_GPR

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cd15072: 7tmA_Retinal_GPR 
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.
Statistics
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PSSM-Id: 320200
Aligned: 13 rows
Threshold Bit Score: 323.542
Created: 10-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      # 
NP_001026387  17 FAIGTALLVEALLGFCLNGLTIISFRKIKELr---tPSNLLVLSIALADCGICINAFIAAFSSFLR-YWPYGseGCQIHG 92  chicken
P23820        19 YFTGSIYLVLGCVVFSLCGMCIIFLARQSPKp---rRKYAILIHVLITAMAVNGGDPAHASSSIVG-RWLYGsvGCQLMG 94  Japanese flying...
NP_001019607  16 FAFGSALLVGGLLGFFLNAISVLAFLRVREMq---tPNNFFIFNLAVADLSLNINGLVAAYACYLR-HWPFGseGCQLHA 91  zebrafish
NP_001017877  17 FSLGSCLLVEGLLGFFLNAVTVIAFLKIRELr---tPSNFLVFSLAMADMGISTNATVAAFSSFLR-YWPYGsdGCQTHG 92  zebrafish
EDL24895      19 LAVGTVLLMEALSGISLNGLTIFSFCKTPDLr---tPSNLLVLSLALADTGISLNALVAAVSSLLR-RWPHGseGCQVHG 94  house mouse
XP_001495838  17 LAVGTVLLVEALAGLSLNSLTILSFCKTPELr---tPSHLLVLSLAVADSGLSLNALVAATSSLLR-RWPYGseGCQAHG 92  horse
P47804        17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELr---tPCHLLVLSLALADSGISLNALVAATSSLLR-RWPYGsdGCQAHG 92  human
NP_001012738  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELr---tPCHLLVLSLALADSGISLNALVAATSSLLR-RWPYGsdGCQAHG 92  human
NP_786969     17 LAVGTVLLVEALSGLSLNILTILSFCKTPELr---tPSHLLVLSLALADSGISLNALVAATSSLLR-RWPYGseGCQAHG 92  cattle
XP_546190     17 LAVGTVLLVEALTGLCLNGLTILSFCKTPELr---tPTHLLVLSLAVADTGISLNALVAAISSLLR-RWPYGpdGCQAHG 92  dog
NP_001088029  17 FAIGTTLLVEALLGILLNGLTLLSFYKIRELr---tPSNLFIISLAVADTALCLNASVAAFSSFLR-YWPYGieGCQIHG 92  African clawed ...
CAF98663      17 FSLGSCLLVEGLLGFFLNAVTVVAFFKVRELr---tPSNFLVFSLAMADMGISMNATVAAFSSFLR-YWPYGseGCQTHG 92  spotted green p...
AGJ70278       1 MLVGGILAALVFVGVTENTTAIYFLHQMKKNarqarPFYILLHAMTACDILVLLTAGMMSSISGLSrKWLFGdaGCKAYA 80  Terebratalia tr...
Feature 1          ##  ##                                                                 ####   
NP_001026387  93 FQGFLTALASISSSAAVAWDRYHHYCTRSKLq---WSTAISMMVFAWLFAAFWATMPL--LGWGEYDYEPlrTCCTLDYS 167 chicken
P23820        95 FWGFFGGMSHIWMLFAFAMERYMAVCHREFYqqmpSVYYSIIVGLMYTFGTFWATMPL--LGWASYGLEVhgTSCTINYS 172 Japanese flying...
NP_001019607  92 FQGMVSILAAISFLGAVAWDRYHQYCTKQKMf---WSTSITISCLIWILAVFWAAMPLpaIGWGVFDFEPlrTCCTLDYS 168 zebrafish
NP_001017877  93 FQGFMTALASIHFIAAIAWDRYHQYCTRTKLq---WSSAITLVLFTWLFTAFWAAMPL--FGWGEYDYEPlrTCCTLDYS 167 zebrafish
EDL24895      95 FQGFATALASICGSAAVAWGRYHHYCTRRQLa---WDTAIPLVLFVWMSSAFWASLPL--MGWGHYDYEPvgTCCTLDYS 169 house mouse
XP_001495838  93 FQGFVTALASICSSAAIAWGRYHHYCTRSRLa---WNTAVFLVFFVWLSSTFWAALPL--LGWGHYDYEPlgTCCTLDYS 167 horse
P47804        93 FQGFVTALASICSSAAIAWGRYHHYCTRSQLa---WNSAVSLVLFVWLSSAFWAALPL--LGWGHYDYEPlgTCCTLDYS 167 human
NP_001012738  93 FQGFVTALASICSSAAIAWGRYHHYCTRSQLa---WNSAVSLVLFVWLSSAFWAALPL--LGWGHYDYEPlgTCCTLDYS 167 human
NP_786969     93 FQGFVTALASICSSAAVAWGRYHHFCTRSRLd---WNTAVSLVFFVWLSSAFWAALPL--LGWGHYDYEPlgTCCTLDYS 167 cattle
XP_546190     93 FQGFATALASICSSAALAWGRYHHYCTRGQLa---WNTAISLVLCVWLSSVFWAALPL--LGWGRYDYEPlgTCCTLDYS 167 dog
NP_001088029  93 FQGFIAALSSIGSCAAIAWDRYHQYCTRSKLh---WSTAVSIVIFVWGFSAFWSAMPL--FGWGEYDYEPlrTCCTLDYS 167 African clawed ...
CAF98663      93 FQGFVTALASIHFVAAIAWDRYHQYCTRTKLq---WSSAITLAVFIWLFCAFWSAMPL--IGWGEYDYEPlrTCCTLDYS 167 spotted green p...
AGJ70278      81 FLSFFFALTNENLIVGISLYRYIFVCKPHYKeflsTKNVYYWIAMSMGYSVFWCSLPL--LGFSNYELEPigIVCSANWQ 158 Terebratalia tr...
Feature 1                    ##   #                                                        #   # 
NP_001026387 168 kgDRNYITFLFALSIFNFMIPGFIMMTAYQSIHQKF------------------KKSGHYKFNTGLPLKTLVICWGPYCL 229 chicken
P23820       173 vsDESYQSYVFFLAIFSFIFPMVSGWYAISKAWSGLsaipdae----kekdkdiLSEEQLTALAGAFILISLISWSGFGY 248 Japanese flying...
NP_001019607 169 qgDRGYITYMLTITVLYLAFPVLVLQSSYSAIHAYF------------------KKTHHYRFNTGLPLKALLFCWGPYVV 230 zebrafish
NP_001017877 168 kgDRNYVSYLIPMSIFNMGIQVFVVLSSYQSIDKKF------------------KKTGQAKFNCGTPLKTMLFCWGPYGI 229 zebrafish
EDL24895     170 rgDRNFISFLFTMAFFNFLVPLFITHTSYRFMEQKF------------------SRSGHLPVNTTLPGRMLLLGWGPYAL 231 house mouse
XP_001495838 168 kgDRNFTSFLLTMAFFNLLLPLLITLTSYRLMEQKL------------------GKTGQLQVNTTLPARTLLLCWGPYAL 229 horse
P47804       168 kgDRNFTSFLFTMSFFNFAMPLFITITSYSLMEQKL------------------GKSGHLQVNTTLPARTLLLGWGPYAI 229 human
NP_001012738 168 kgDRNFTSFLFTMSFFNFAMPLFITITSYSLMEQKL------------------GKSGHLQVNTTLPARTLLLGWGPYAI 229 human
NP_786969    168 rgDRNFTSFLFTMAFFNFLLPLFITVVSYRLMEQKL------------------GKTSRPPVNTVLPARTLLLGWGPYAL 229 cattle
XP_546190    168 rvDRNFTSYLFTMAFFNFFLPLLITLVSYRLMEQKL------------------KKPGHLQVSTTVPARTLLLCWGPYAL 229 dog
NP_001088029 168 krDRNFISFLFTMAFFEFLVPLFIILTAYQSIYQKM------------------KKNGQIRFNTSMPVKTLVFCWGPYCL 229 African clawed ...
CAF98663     168 kgDRNYVSYLVPMAIFNMVIQVFVVMSSYQSIAEKF------------------KKTGNPRFNPNTPLKAMLLCWGPYGI 229 spotted green p...
AGJ70278     159 snELDSVSYTCLIMFFCFILQAIILGKLYHEIVNKTkglfgfagcnssiitkmkKLEKRRNWLCLLLVLTFIITWSPYAI 238 Terebratalia tr...
Feature 1                              #   #                      
NP_001026387 230 LSFYAaien-vmfISPKYRMIPAIIAKTVPTVDSFVYALGNe-nYRGGI 276 chicken
P23820       249 VAIYSalthggaqLSHLRGHVPPIMSKTGCALFPLLIFLLT---ARSLP 294 Japanese flying squid
NP_001019607 231 VCSLAcfed-vsvLSPRLRMVLPVLAKTSPIFHAVLYAYGNe-fYRGGV 277 zebrafish
NP_001017877 230 LAFYAaven-atlVSPKLRMIAPILAKTSPTFNVFVYALGNe-nYRGGI 276 zebrafish
EDL24895     232 LYLYAaiad-vsfISPKLQMVPALIAKTMPTINAINYALHRemvCRGTW 279 house mouse
XP_001495838 230 LYLYAtvad-atsISPKLRMVPALVAKTVPTINAVNYALGSemlHRGIW 277 horse
P47804       230 LYLYAviad-vtsISPKLQMVPALIAKMVPTINAINYALGNemvCRGIW 277 human
NP_001012738 230 LYLYAviad-vtsISPKLQMVPALIAKMVPTINAINYALGNemvCRGIW 277 human
NP_786969    230 LYLYAtiad-atsISPKLQMVPALIAKAVPTVNAMNYALGSemvHRGIW 277 cattle
XP_546190    230 LYLYAtvad-vrsVPPKLQMVPALIAKAAPTINAIHYALGGd-mVHGGL 276 dog
NP_001088029 230 LCFYAviqd-atiLSPKLRMMPALLAKISPAVNAYVYGLGNe-nYRGGI 276 African clawed frog
CAF98663     230 LAFYAaven-anlVSPKLRMMAPILAKTCPTVNVFLYALGNe-nYRGGI 276 spotted green pufferfish
AGJ70278     239 ISMLRrit---gpIDKWIHAFPILLAKTSPVICPIIYRFAGh-dFNMSM 283 Terebratalia transversa

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