Conserved Protein Domain Family
BLOC1_CNL1
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cd24144: BLOC1_CNL1 
Biogenesis of lysosome-related organelles complex 1 subunit CNL1
Biogenesis of lysosome-related organelles complex 1 (BLOC-1) subunit CNL1, also called CNO-like protein 1, is part of a complex that is involved in endosomal cargo sorting. BLOC-1 is an endosomal Rab-GAP (GTPase-activating protein) adapter complex that is composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2. Saccharomyces cerevisiae CLN1 is believed to be the homolog to the cappuccino (cno) subunit of the BLOC-1 complex in higher eukaryotes.
Links
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Statistics
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PSSM-Id: 467944
Aligned: 17 rows
Threshold Bit Score: 96.181
Created: 14-Mar-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q06333        17 DPLGIDKLTVDYDYLLYKMRDYVQSIQLd-TTELCKKQNEVmv-nGIIENTIDKNIAKFKELLEKCDTLENHYEMLNQLA 94  Saccharomyces c...
XP_454923     22 DPFNIDKLIVDYDYLLYKIQDELESIQLk-TLEICQKQNEIve-hGIIEEVIDGNIGMAKDLLQKCDDLEKHYDQLDAVE 99  Kluyveromyces l...
C5DY20         8 DSLGIDKLSVDYDYLLYKIADYVSSIEFq-TNQICKRQNELit-kDIVNGIVDENIKHFREILTKCEKLENYFDMLDQIN 85  Zygosaccharomyc...
C5DJH5        26 DPFGIDRLSVDYDYLLYRIQDHVTSIQLs-TTEICRQQNQLve-qGIIGDAIDINIEEMRRILQKCEELETHFDMLDQID 103 Lachancea therm...
Q756L2        17 DPFRVDQLILDYDYMLYRIKDHVASIHLa-TTELCRKQNQLvc-tGIVEEIIDSNIKNVRELLTKCKELETYFEQLHAID 94  Eremothecium go...
A7THV0        16 EMLGIDKLSVDYDYLLYKINDYVNSIQIq-TKEVCQRQNELis-qNVVEDIVDVNIQSFKDILSKCEELENYFTMLDQIE 93  Vanderwaltozyma...
XP_045934157  32 DPLDINKLSLDYDYLMYKISDYISAIHQq-TTDIVRQQSDLit-kGIINTQIDQTIENCKGVLSKCHDLEDACDMLENID 109 Saccharomycodes...
Q6FY24         6 ESLGIDQLSVDYDYLVYRISDRVKSLELe-ATRLVQRQNELv--gQVSERVIDENIERFRGVLRGLDELEEYFAMMEQIG 82  Nakaseomyces gl...
XP_028893002   6 DPLKIKDLAVTYDYLMYKIHDHIATLSEttYKSVQTKQRLIeqdyFQHQLHLDENVAEIQSLLKSCDDIELQFMKLDQLY 85  [Candida] auris
XP_036663993  44 DPLELHKLSLSYDYLMFKIKDYIRTLTDqtYESVVQKQDRInhdyFDKQLNLPQQYEEIDKLLRTCNDLEQEFMKIDQLE 123 Candida parapsi...

Q06333        95 IITDTFKER 103 Saccharomyces cerevisiae S288C
XP_454923    100 GIVVSFKSR 108 Kluyveromyces lactis
C5DY20        86 MITENFKTR 94  Zygosaccharomyces rouxii
C5DJH5       104 SIVQTFRPR 112 Lachancea thermotolerans CBS 6340
Q756L2        95 GIVSTFHER 103 Eremothecium gossypii ATCC 10895
A7THV0        94 MISDTFHGR 102 Vanderwaltozyma polyspora DSM 70294
XP_045934157 110 SIIDEFFIR 118 Saccharomycodes ludwigii
Q6FY24        83 MITDSFKER 91  Nakaseomyces glabratus
XP_028893002  86 SFVDDFKAR 94  [Candida] auris
XP_036663993 124 IFVHDFKQR 132 Candida parapsilosis
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