Conserved Protein Domain Family
Gly_reductase

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pfam09338: Gly_reductase 
Glycine/sarcosine/betaine reductase component B subunits
This is a family of glycine reductase, sarcosine reductase and betaine reductases. These enzymes catalyze the following reactions. sarcosine reductase: Acetyl phosphate + methylamine + thioredoxin disulphide = N-methylglycine + phosphate + thioredoxin Acetyl phosphate + NH(3) + thioredoxin disulphide = glycine + phosphate + thioredoxin. betaine reductase: Acetyl phosphate + trimethylamine + thioredoxin disulphide = N,N,N-trimethylglycine + phosphate + thioredoxin.
Statistics
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PSSM-Id: 430538
Aligned: 52 rows
Threshold Bit Score: 532.498
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
goetting:EAL2_c02900   1 MKLELGNFYVEEIVFGEKTSFKDGVLTINKQEALDY-VME-DENITHAELHIVKPGDMVRLCPVKEAIEPRIKLDGR-TY 77 
jgi:Anamo_1046         1 MKLEIGNFFVKDIVFGDRTFYERGVLTVNKKEALDV-VFE-DSHITEAELYIVRPGDEVRLVPVKEAYEMRCKVSGGqSV 78 
EHM12619               1 MRLEIGNFPVKSMVFGGETSYRDGVLTLNREELLAV-VRE-DEHITEADLRIVYPGDKVRLCPVKESVQMRCKVSGGeGI 78 
jgi:Tlie_1459          1 MKLEMGKFYIKDIVFGDETKVENGVLVVNKEEALKI-VRE-DEHITSADLHIVRPGDRVRLCPVKEALEIRCKVEGGtGI 78 
WP_012799646           1 MKLTIGNVYVKDVCLGTENSFVDGILTINKDDAIAY-LKEeDDHITDLDIVIAHPGDDTRIVPVIETIEPRVRMDGR-CL 78  Slackia...
WP_012291117           1 MKFEIGNFNVKDVVFGDKTKFENNILTINKQEAIEF-IKR-DEHITECDIEIAKPGDEVRIVPIKEAVEPRIRPDKR-AV 77  Finegol...
WP_020963866           1 MKLEIGNFQVKNAVFGKETSFKDGVLTINKDEAVAF-IKK-DSHITNADIEIARPGEKVRIVPIKEAVEPRCRIDGR-PL 77  Trepone...
WP_014552328           1 MKLELGNFKVKEIEFGTETTFKNGVLTINKEEALEV-VFK-DKHITEADLKIVKPGDMVRLVPVKEAIEPRFRVGGG-PV 77  Halanae...
jgi:Halha_2199        43 vRLEIANFNVEDITFGDETSYQDGTLIINKEEALKV-VKE-DEHITEADIKIARPGEDKRIVPVKEAIEPRCKADGG-AV 119
CCX49656               6 NT-------VKRVTFGDNSSYQNGLLTVSKEELSAAaLKNtDGKY-AFDIDVCCPGEKTRIVHITDAIKPSYKPDAA--A 75 
goetting:EAL2_c02900  78 FPGVTdEELTRCGEGRTHALKGCSVLVVGKHWGgFQDGLIDMGGEGAKYTYYSTLKNIVLVGDTNE-DFEKNEQQKknkA 156
jgi:Anamo_1046        79 YPGCT-APVAPVGSGRTHALKGCSLLVVGKHWGsFQDGLIDMSGPAQRNTIFGSMPNLVLVGDTDE-EFERHEQQKknrA 156
EHM12619              79 FPGVT-SPMNLAGEGRTHCLTDCSLLVVGRHWGgFQDGLIDMAGPYQHYTIWGDMPNLVLVADIDE-LFEQREQQKknhA 156
jgi:Tlie_1459         79 FPGVT-SPLARAGMGRTHVLSGCSLLVVGEHWGgFQDGLIDMSGKYQNQCIFGMMPNLVLVADTDE-EFERHEQQKknrA 156
WP_012799646          79 FPGVT-GELEPCGDGDLKAFKGCCVTVVGKEWGsFGDGVIDMGGEGAKHTYWSKLINICLVGDTDE-EFERHEQQKcnhA 156 Slackia...
WP_012291117          78 FPSIT-GELVPTGEGRVHALKGVSVLGVGMHWGsFGDGLLDMSGEGANYSYFSQLINVCLVIDTDE-EFERHEQQKknhA 155 Finegol...
WP_020963866          78 FPGVT-GKTVSAGEGTVHALKGVSILGVGMHWGsFGDGLIDMWGEGAKYSMYSSLINICLVIDTDE-ADERNEQQKknrA 155 Trepone...
WP_014552328          78 FPGVT-GKLSQAGEGKTLCLKDMSVLVVGKHWGgFQDGLIDMGGEGAKYTHFSSLKNVVLVADTDE-EFEQQEQQKknhA 155 Halanae...
jgi:Halha_2199       120 FPGVT-DNVEAVGEGQTLALKGCSVLAVGKHWGsFGDGLIDMSGEGAKYTYFSQLNNICLVADTDE-EFERHEQQKknhA 197
CCX49656              76 FPGWT-EGENKCGQGETVQLENLCLLQTFAYPG-IQEGIVDMSGEGAKYSLFSKKINLVMSVKLLDtAIEKPVLAK---D 150
goetting:EAL2_c02900 157 LRWAGHKLAEYIG-KTVKDMEP--QEVETYELEPVTQRSEEVTKLPGVVFVMQPQSQmeELGYNDMVYGWDMNRMVPTYM 233
jgi:Anamo_1046       157 LRWAGMRLSEYVG-KCVKDLEP--EEIETWELEPVNERASDVRNLPSVVYVPQIQTQmeALGYNALVYGWDGNRMLPTYL 233
EHM12619             157 LRWAAMRLAEHIG-QCVKDLKP--ESVDVFDLPPLDARDEKTRALPGVVCVLQPQTQmeAKGYNTLIYGWDGHDILPTFM 233
jgi:Tlie_1459        157 LRWAGMRLAEHIG-QCVKDATP--DEVEVFDLPPVNRRPAEVQALPSVVYVIQPQTQmeQLGYNTLIYGWDGNRMLPTFM 233
WP_012799646         157 LRWAGHRFAEYIG-KIAKDLEP--ADTEVYEFDPVLKRDDARKDLPNVAIVLQPQSQmeALGYNDLLYGWDMNRYLPSFI 233 Slackia...
WP_012291117         156 IRWACHLFAEYLG-ETVIDQQP--EEIEKYEFTPVTRRSDEVNKLPSVVLVMQPQSQmeELGYNDLIYGWDMNKYLPTFM 232 Finegol...
WP_020963866         156 IRYAAHRFAEYLG-KTVQNQTP--ETKDIYDYQPIFNRSPEIEKLKRVVLVMQPQSQmeEMGYNDLFYGWDLNRYVPTLV 232 Trepone...
WP_014552328         156 LRWAGMRLAEYLG-QTVKDLEP--EATDTYELEPLTERAAAVSDLPNVALVMQPQSQmeDSGYNTLNYGWDTNRMLPTLM 232 Halanae...
jgi:Halha_2199       198 LRWAGHRLAKYLAtEALEDQEPaeDDIEEFDLEPITKRPAKVNDLPSVVYVMQAQSQmeEMGYNDLVYGWDMNHVVPTLM 277
CCX49656             151 LVRMQTQAAEYLA-SIAKDACE--KKIEINNPQP--------SSLPRVGYAYFVQAQ--GPLRNVFMYGKECVNMKATYL 217
goetting:EAL2_c02900 234 HPNEVLDGAIISGSFMPCSSKWSTYDFQNFPALKRLYAEHGKTVNFLGVIMSNLNVALQQKQRSALFVAQMAKSLGAQGA 313
jgi:Anamo_1046       234 HPNEILDGAIISGSFMPCSSKISTYEWVNNPMIKCLMREHGRTINFLGVVLSNLNVVMEEKARSAMMVANIAKALGADGA 313
EHM12619             234 HPNELLDGCLVSGSFMPTSSKISTYEYQVNPMIRRLYAEHGKTINFLGVVMSTLNPKMDEKFRCVKMAGQIAVAVGAKGA 313
jgi:Tlie_1459        234 HPNEILDGAVVSGSFMPVSSKISTYEWCNHPTIHRLMKEHGKTINFLGVIMSTLNPKMEEKERCAKMVAQMAVNLGADGA 313
WP_012799646         234 SPTEIFDGCIISGSFMPASSKWSTYEFQNFPTIKEMFKYDGIEYNFVGVIMSNLNVALDQKERSAIMVRNIALNLGVDYA 313 Slackia...
WP_012291117         233 SPTEVLDGCIIGGSFMPCSSKWATYDFQNFPIIKELFKEHGKSINFLGVIMSNLNVSLEQKERAAIFVSNMAKSLGADGA 312 Finegol...
WP_020963866         233 NPNVIFDGGIISGSFMPCSSKWSTYDFQNFEIIKQLYKEHGKTINFLGVILSNLNVSLEQKERSALIMGSIAKMIGAEGA 312 Trepone...
WP_014552328         233 HPNEILDGAMISGSFMPCSSKWSTYDFQNFPLIRSLYAEHGKTINFVGVIMSNLNVALEQKERSALFVAQMAKSLGVEAA 312 Halanae...
jgi:Halha_2199       278 HPNEILDGAMISGSFMPCSSKWSTYDFQNCPTIKNLYQEHGETINFLGVIMSNLNVNLEEKERSALFVQQIAKSLGADAA 357
CCX49656             218 SPAEIIDGALVSGNYIIACQKNPTIYHQENPVIRYGIANSGKEMDFVGAICATESNLLDGKRESAASITQKALELHCDGM 297
goetting:EAL2_c02900 314 IVAEEGYGNPDADFIACIVALENEGIKTVGLTNECTGRDGFSQPLVTLDEKANAIVSCGNVSELVELPPMPVVLGELeaL 393
jgi:Anamo_1046       314 IVAEEGYGNPDVDYILTIVELEKAGIKTVGMTNECTGRDGTSQPLVALDERANALVSTGNVSELYELPPMKTVLGELesL 393
EHM12619             314 VVIEEGYGNPDVDYTAMLVELERLGIKTIGLSDECVGRDGASQPLVSLNPATNALVTTGNVSQMYNLEPME-VIGELeaL 392
jgi:Tlie_1459        314 IVCEEGYGNPDVDYIQTIVELEKAGVKTVGISDECTGRDGASQPLVALDERADALVTTGNVSELYHLEPMPVVLGELeaL 393
WP_012799646         314 IVTEEGYGNPDTDYVRCQVILEDAGIPVVGISNESDGRDGAGQPLVVMDEKTNALVSTGNVGELTELPACATVIGNLeaM 393 Slackia...
WP_012291117         313 IVTEEGYGNPDADYVRCICALEDVGVKVVGISNECTGRDGKSQPLVVMNEKTDALVSTGNVSQLIRLKPMKKVIGELeaL 392 Finegol...
WP_020963866         313 IVTEEGYGNPDTDYIRCIVELENLGIKTVGISNECVGRDGASQPLVVLDEKANALVSTGDVSDLIELPPAEKVIGELeaL 392 Trepone...
WP_014552328         313 IVTEEGYGNPDADYIGCLVALEDAGVKTVGVSNEATGRDGGSQPLVTLDPKADALVSTGNVSELIKLPPMDEVIGELeaL 392 Halanae...
jgi:Halha_2199       358 ILAEEGYGNPDADFIECFKALEEAGVKTVGMTNECTGRDGNSQPLVTLDEAADAIVSCGNVSALIELPPMETVIGELeaL 437
CCX49656             298 IITQEGGGHADVDLIFTNDALTDAGIRTVVIANEIAGPDGILPPLVSFSSKVDATISTGNNDQVIELDAMDKSIGG---- 373
goetting:EAL2_c02900 394 ARDGLSGGWAGdeilgsSVKADGSVIMENNAMFCGDQVVGWSTKTMK 440
jgi:Anamo_1046       394 ARDGLSGGWEG------CVREDGSVIMENNAFFCSDHISGFSLKTCA 434
EHM12619             393 ARDGNSGGWEG------CVNPDGSAVMENNGMFCANHISGFSMRTCa 433
jgi:Tlie_1459        394 ARDGNSGGWEG------CIEEDGSVWMENNGYFCSNHISGFSKKTCA 434
WP_012799646         394 NRDGMSGSWGYdeilgkSARDDGSIIMEDNNWFCGDHIAGFSIKTMR 440 Slackia heliotrinireducens
WP_012291117         393 ARDGLSGGWAGdeilgpSVKEDGSVIMENNAMFCGDQIAGWSRKTMK 439 Finegoldia magna
WP_020963866         393 GRDGLSGGWAYdevlgpSVRKDGSILMENNAMFCGDGISGWSVKTMK 439 Treponema pedis
WP_014552328         393 ARDGLSGGWADdeilgsSVKEDGSIVMENNSMFCGDRIAGWSPKTMK 439 Halanaerobium praevalens
jgi:Halha_2199       438 ARDGLSGGWEDddelgsSVKEDGSIIMENNSMFCGDQVLGWSPKTMK 484
CCX49656             374 --DAISNGAHN--------ATD-SFKTPLGIMYTATNQLGVSNMTTK 409
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