4IDQ,3X1D,6K1Z


Conserved Protein Domain Family
GBP
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pfam02263: GBP (this model, PSSM-Id:308078 is obsolete and has been replaced by 460516)
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Guanylate-binding protein, N-terminal domain
Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.
Links
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Statistics
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PSSM-Id: 308078
Aligned: 12 rows
Threshold Bit Score: 370.936
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4IDQ_C     44 DHSFELDETALNRIllseAVRDKEVVAVSVAGAFRKGKSFLMDFMLRymynqesv-----------dwvgdynePLTGFS 112 human
P32456     18 KGQLVVNPEALKIL----SAITQPVVVVAIVGLYRTGKSYLMNKLAG---------------------------KKNGFS 66  human
Q01514     18 EAQLVINQEALRIL----SAITQPVVVVAIVGLYRTGKSYLMNKLAG---------------------------KRTGFS 66  house mouse
Q8NHH9     70 DHNFELDEEALEQIllqeHIRDLNIVVVSVAGAFRKGKSFLLDFMLRymynkdsq-----------swiggnnePLTGFT 138 human
Q9BMU4     43 DHSFELNTELLEKIlldpKVADKKVAVIGVAGAYRKGKSFLLNFFLRyltwrskadkvmgeveldnsqwmspnsPLSGFS 122 Caenorhabditis ele...
3X1D_A     14 EHTFVLNEDALSEVlmrdEVKDRFVCVVSVAGAFRKGKSFLLDFFLRymyskyvhhd-------atdwlggesdPLEGFS 86  fruit fly
Q8N8V2     18 KGHLVVNSEALEIL----SAITQPVVVVAIVGLYRTGKSYLMNKLAG---------------------------KNKGFP 66  human
Q91Z40     18 NEELRVNSKAINIL----ERITQPVVVVAIVGLYRTGKSYLMNRLAG---------------------------QNHGFN 66  house mouse
Q61107     12 KNQLTVNLEAIRIL----EQIAQPLVVVAIVGLYRTGKSYLMNRLAG---------------------------RNHGFS 60  house mouse
Q96PP8     18 NEQLKVNQEALEIL----SAITQPVVVVAIVGLYRTGKSYLMNKLAG---------------------------KNKGFS 66  human
6K1Z_A     20 NGRLMANPEALKIL----SAITQPMVVVAIVGLYRTGKSYLMNKLAG---------------------------KKKGFS 68  human
NP_989983  19 dGVLALNPAALAVL----HSVTQPVVVVAIAGLYRTGKSFLMNQLAQ---------------------------KRTGFP 67  chicken

4IDQ_C    113 WRGGSERETTGIQIWSEIflinKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHL 191 human
P32456     67 LGSTVKSHTKGIWMWCVP----HPKKPEHTLVLLDTEGLGDiEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQL 142 human
Q01514     67 LGSTVQSHTKGIWMWCVP----HPKKAGQTLVLLDTEGLEDvEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQL 142 house mouse
Q8NHH9    139 WRGGCERETTGIQVWNEVfvidRPNGTKVAVLLMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHL 217 human
Q9BMU4    123 WRGGSERDTNGILIWSEPfimkDKNGEEIAVLLMDTQGAFD-SQSTVKDCATIFALSTMISSVQIYNLSQNIQEDDLQHL 201 Caenorhabditis ele...
3X1D_A     87 WRGGSERDTTGILMWSDIflhdYPNGDKIAIILLDTQGAFD-SQSTVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHL 165 fruit fly
Q8N8V2     67 LGCTVKSETKGIWMWCVP----HPSKPNHTLILLDTEGLGDmEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQL 142 human
Q91Z40     67 LGTTVRSETKGIWMWCVP----HPSKPKFTLVLLDTEGLGDvEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQL 142 house mouse
Q61107     61 LGSTVQSETKGIWMWCVP----HPTKPTHTLVLLDTEGLGDvEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQQALEQL 136 house mouse
Q96PP8     67 VASTVQSHTKGIWIWCVP----HPNWPNHTLVLLDTEGLGDvEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLL 142 human
6K1Z_A     69 LGSTVQSHTKGIWMWCVP----HPKKPGHILVLLDTEGLGDvEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQL 144 human
NP_989983  68 LGPTVYAETKGIWMWCLP----HPRQPRVTLVLLDTEGLGDpNkDDDHSDAWIFTLALLLSSTLVYNSIGTIDQRALEQL 143 chicken

4IDQ_C    192 QLFTE--------------YGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQN---V 254 human
P32456    143 HYVTEltdrik--ansspgNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSfndP 220 human
Q01514    143 HYVTEltdlik--sksspdQSDVDNSANFVGFFPIFVWTLRDFSLDLEFDGESITPDEYLETSLALRKGTDENTKKfnmP 220 house mouse
Q8NHH9    218 QLFTE--------------YGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEELQN---V 280 human
Q9BMU4    202 QLFTE--------------YGRLALEDSASKPFQSLLFLVRDWSFPYEAEFGFQGGQRVLDRRLEVSEKQHAELQQ---L 264 Caenorhabditis ele...
3X1D_A    166 QLFTE--------------YGRLALADTGKKPFQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQS---L 228 fruit fly
Q8N8V2    143 HYVTEltelir--akscprPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNsnkP 220 human
Q91Z40    143 HYVTElterir--akstsrSEEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKanlP 220 house mouse
Q61107    137 HFVTEltqlir--akssprEDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQsnmT 214 house mouse
Q96PP8    143 HNVTEltdllk--arnspdLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNfnlP 220 human
6K1Z_A    145 YYVTElthrirsksspdenENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETfnlP 224 human
NP_989983 144 RLVTElseh------irvrEKDNNPASNFVSIFPGFVWTVRDFTLQLRAGEKTLSEDEYLEDVLRLQTGGGQKAQErneL 217 chicken

4IDQ_C    255 RKHIHSCFTNISCFLLPHPGLKVATnPNFDG-KLKEIDDEFIKNLKILIPWLLSpESLDIKE 315 human
P32456    221 RLCIRKFFPKRKCFVFDWPAPKKYL-AHLEQlKEEELNPDFIEQVAEFCSYILS-HSNVKTL 280 human
Q01514    221 RLCIRKFFPKRKCFIFDRPGDRKQL-SKLEWiQEDQLNKEFVEQVAEFTSYIFS-YSGVKTL 280 house mouse
Q8NHH9    281 RKHIHNCFSNLGCFLLPHPGLKVATnPSFDG-RLKDIDEDFKRELRNLVPLLLApENLVEKE 341 human
Q9BMU4    265 RQHIRSCFEDIRCFLMPHPGLKVATnPNFDG-KLVDIENEFQQQLGVMIPRLLDsHALVHKE 325 Caenorhabditis elegans
3X1D_A    229 RRHISSCFTEVACFLMPHPGLNVATnPKFDG-RLQDITPEFKSSLRSLVPMLLApDNLVYKE 289 fruit fly
Q8N8V2    221 REWIRHFFPKQKCFVFDRPINDKKLlLHVEEvREDQLDSNFQMQSENFCSYIFT-HAKTKTL 281 human
Q91Z40    221 RECIRHFFPRRKCFVFDRPTKDKELlVHVEEmPEDQLDHSFQVQSKEFCSYIFS-NSKAKTL 281 house mouse
Q61107    215 RECIRYFFPVRKCFVFDRPTSDKRLlLQIENvPENQLERNFQVESEKFCSYIFT-NGKTKTL 275 house mouse
Q96PP8    221 RLCIQKFFPKKKCFIFDLPAHQKKL-AQLETlPDDELEPEFVQQVTEFCSYIFS-HSMTKTL 280 human
6K1Z_A    225 RLCIRKFFPKKKCFVFDRPVHRRKL-AQLEKlQDEELDPEFVQQVADFCSYIFS-NSKTKTL 284 human
NP_989983 218 RRCLRNFFPRRKLFTMERPAADADL-TRLEElREDELQPGFRKQVDAFCRYIWE-EAPVKVl 277 chicken
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