1R57


Conserved Protein Domain Family
Acetyltransf_CG

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pfam14542: Acetyltransf_CG 
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GCN5-related N-acetyl-transferase
This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.
Statistics
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PSSM-Id: 434030
Aligned: 178 rows
Threshold Bit Score: 60.9969
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1R57_A        12 KFYIGD-De-NNalAEITYRf-VDNnEINIDHTGVSDELGGQGVGKKLLKAVVEHARENNLKIIASCSFAKHML--EKED 86 
EDV26219      72 GLQCNI----LNdkAVLQYSlaQNEgVIDMLHTGVPPRFRGMGVAKLLAQTAFDYALQNRFKMKLSCWYLAEYL--QKNP 145
Q7QES7        38 KFVIAL-G--ESdeAYLKYSenRTSnTISLEHTFVPDAGKGKGLGKQLAEAAFQYAIEKQLKVKLECDFTVKYF--KDNE 112 Anopheles gambi...
EDS36207      37 EFSVHL----NEskAFLSYRldRKArVLSLDHTEVPAVFQGKGVGKKLVEAALQHAMQEDLKVKIYCDFALKYY--RDNE 110
EEC07900      46 EFFIRL----GNdkAVLQYEv-LNPkTLDLVHTEVPEALRGKGIAKHLAKAAFNFVAANSFQARVTCPYVNKYV--NEEG 118
Q5D014        26 QFSIRLnG--SHdkAVLLYEy-VGKkTVDLQHTEVPEAYRGREIAKHLAKAAMDFVVEEDLKAHLTCWYIQKFV--KENP 100 zebrafish
XP_003198232  47 RFTITLncdgTVrcAVLKYTv-RHDqRLELLSTEVPQSHRGKGVAAHLAKAALDFIVEENLKVRISCWYIRKYV--NENP 123
XP_002591297  19 EFYIRMeRe-STekAILQYDm-YRKgYVDFYHTFVPEVYRGKGLAKHLAKAALDYAVEEDLKMKLTCTYLQKYA--KDNP 94 
EFX80448      24 KFCIKL-D--DEneAVLVYE--KKQgMIDMYHTEVPMGYTGRGIAGLLAKAAFDHAVEKEMKMKLSCTYLHNYLhnSLKD 98 
XP_002073903  14 FFYIEI-D--Gi-rADLRYs--vKDgTMIFWHTNVPEELGGQGVGKALAKVALDYALRNGLFLVIKCQFVQHYI--DKYE 85 
1R57_A        87 -S-Y-QDV 91 
EDV26219     146 kReYeELV 153
Q7QES7       113 -SkYkAYV 119 Anopheles gambiae str. PEST
EDS36207     111 -----AQL 113
EEC07900     119 dSeFrAFV 126
Q5D014       101 hPqYlERI 108 zebrafish
XP_003198232 124 hLgYqAYI 131
XP_002591297  95 lPqYqERI 102
EFX80448      99 -DtKeKYL 105
XP_002073903  86 pQ-Y-AKY 91 
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