3D42,3O4S


Conserved Protein Domain Family
PTPc-N7
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cd14612: PTPc-N7 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 7
Tyrosine-protein phosphatase non-receptor type 7 (PTPN7), also called hematopoietic protein-tyrosine phosphatase (HePTP) or LC-PTP. belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN7/HePTP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. PTPN7/HePTP is found exclusively in the white blood cells in bone marrow, thymus, spleen, lymph nodes and all myeloid and lymphoid cell lines. It negatively regulates T-cell activation and proliferation, and is often dysregulated in the preleukemic disorder myelodysplastic syndrome, as well as in acute myelogenous leukemia.
Links
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Statistics
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PSSM-Id: 350460
Aligned: 6 rows
Threshold Bit Score: 488.191
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 15 residue positions
Conserved feature residue pattern:x x x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Structure:3D42: Human HePTP binds monophosphorylated Erk2 peptide; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #####                                                        
3D42_A        53 PSNFVSPEDLdipghasKDRYKDILPNpqSRVCLGRaqsq---edgdYINANYIRGYdgkekVYIATQGPmpntvsDFWE 129 human
3O4S_A        53 PSNFVSPEDLdipghasKDRYKTILPNpqSRVCLGRaqsq---edgdYINANYIRGYdgkekVYIATQGPmpntvsDFWE 129 human
NP_001167320 105 PTNFVNPSELdipgralKDRYKTILPNpeTRVCLRNpaaeeageterYINANYIKGYngapsTYIATQGPmlntvhDFWE 184 Atlantic salmon
XP_004934878 108 PPNFISPEELeipghasKDRYKTILPNpeSRVCLRRagsq---eedgYINANYITGYagrprEYIATQGPmlntvtDFWE 184 chicken
XP_005995506 107 PPNFVNPDELdipghasKDRYKSILPNpqSRVCLQRrgnqn--eetsYINANYIMGYegkekAYIATQGPmantvsDFWE 184 coelacanth
XP_007892377 109 PPNFIETNELnipghasKNRYKTILPNpqTRVCLKSekhsd--dlssYINANYIRGYggeekAYIATQGPmvntvnDFWE 186 elephant shark

Feature 1                                                                                   ##   
3D42_A       130 MVWQEEvSLIVMLTQLregkEKCVHYWPteeetygpFQIRIQDMKECpeYTVRQLTIQyqeeRRSVKHILFSAWPDHQTP 209 human
3O4S_A       130 MVWQEEvSLIVMLTQLregkEKCVHYWPteeetygpFQIRIQDMKECpeYTVRQLTIQyqeeRRSVKHILFSAWPDHQTP 209 human
NP_001167320 185 MVWQERsTTIVMITKLkekkEKCELYWPekegsygrFELRVAIAKECdgYTIRDIIIQvgseSRQVRHYWYSTWPDHQTP 264 Atlantic salmon
XP_004934878 185 MVWQEEaPIIVMITKLqerkEKCVHYWPekegtygpFTIRVQGISEYaeYVVRSLSIQlegeCRHVKHILFPSWPDQQTP 264 chicken
XP_005995506 185 MVWQEDcPIIVMITKLkekkEKCDLYWPekegtygrFGIQVNKMKECdgYTIRDLTIKlegaSRNITHYWYSSWLDHQTP 264 coelacanth
XP_007892377 187 MVWQEDcPMIVMITKLkeknEKCVVYWPekqssfgrFEVVVNEVKECdgLAIRDLSVKhaeeSRSVKHYWFSSWPDHQTP 266 elephant shark

Feature 1                                     #######                                     #      
3D42_A       210 esAGPLLRLVAEVEESpetaahpgPIVVHSSAGIGRTGCFIATRIGCQQLkaRGEVDILGIVCQLRLDRGGMIQTAEQYQ 289 human
3O4S_A       210 esAGPLLRLVAEVEESpetaahpgPIVVHCSAGIGRTGCFIATRIGCQQLkaRGEVDILGIVCQLRLDRGGMIQTAEQYQ 289 human
NP_001167320 265 dcTGPLLRLVADVEEHrqshpslgTTIVHCSAGIGRTGCFIASSIGCLQLkhTSKADVLGIVCKLRLDRGGMIQTSEQYQ 344 Atlantic salmon
XP_004934878 265 esAKPLLHLVSKVEETlqaaaspgPIIVHCSAGIGRTGCFIATRIGCQQLkdKGDVDILGIVCRLRIDRGGMIQTSEQYQ 344 chicken
XP_005995506 265 ecGQPLLHLITEVEERrlvatskgPVVVHCSAGIGRTGCFIAASIGCQQLkkKGAVDILGIVCQLRLDRGGMIQTSEQYQ 344 coelacanth
XP_007892377 267 dtAQSLLDLVLEVEESrktagnrgPVVVHCSAGIGRTGCFVATSIGCQQIkdTDKVDILGIVCQMRTDRGGMIQTSEQYE 346 elephant shark

Feature 1                 
3D42_A       290 FLHHTLALY 298 human
3O4S_A       290 FLHHTLALY 298 human
NP_001167320 345 FLYLTLAQY 353 Atlantic salmon
XP_004934878 345 FLHHTLALY 353 chicken
XP_005995506 345 FLYRSLALF 353 coelacanth
XP_007892377 347 FLHSTLCLY 355 elephant shark

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