1H2T,6D0Y,5OO6,1H6K


Conserved Protein Domain Family
RRM_NCBP2

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cd12240: RRM_NCBP2 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
This subfamily corresponds to the RRM of CBP20, also termed nuclear cap-binding protein subunit 2 (NCBP2), or cell proliferation-inducing gene 55 protein, or NCBP-interacting protein 1 (NIP1). CBP20 is the small subunit of the nuclear cap binding complex (CBC), which is a conserved eukaryotic heterodimeric protein complex binding to 5'-capped polymerase II transcripts and plays a central role in the maturation of pre-mRNA and uracil-rich small nuclear RNA (U snRNA). CBP20 is most likely responsible for the binding of capped RNA. It contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and interacts with the second and third domains of CBP80, the large subunit of CBC.
Statistics
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PSSM-Id: 409686
Aligned: 37 rows
Threshold Bit Score: 108.044
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
chemicalsubunit
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:1H2T; human nuclear Cap-binding-complex binds GDP/m(7)GpppG complex, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #                                       # #                          # ###   
1H2T_Z        42 LYVGNLSFYTTEEQIYELFSKSGDIKKIIMGLDKmkKTACGFCFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGF 119 human
XP_002669370  48 IYVENLSFYTKEEQIYELFEKCGEVKRVVMGLNRntLTPCGFCFVEFYHRSDAEECVKYCRGCKLNNRALKIAIDTGF 125 Naegleria gruberi...
XP_001315386  40 IYVGNLNFSTTEAAIYSVFSQFGPIKRIIRGVNKltLTPCGFCFVEFFDRASALATLGKSIKIKIDGEIVRCDLDRGY 117 Trichomonas vagin...
Q08920        48 IYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRfkFTPCGFCFIIYSCPDEALNALKYLSDTKLDEKTITIDLDPGF 125 baker's yeast
XP_652915     35 LYVGNVSHSMNDKRVYTLFGRFGNINRVIMGVNHs-NEPCGFCFVEFNKRNDAALAMKALDRTQVFGQYIRIDWDYGF 111 Entamoeba histoly...
XP_001713236   7 IYVGSLSKKLKENFLWYFFSRLGKIKRLIIGINNktLLPCGFCFVEYFFDFNFELSFKVLSGFRIFNHFIKLDKDNGF 84  Guillardia theta
Q9P383        34 VYVGNLSFYTTEEQIYALFSKCGEIRRIIMGVDRftKTPCGFCFVEYFENQDALDSLKYISRTSLDERIIRADLDHGY 111 fission yeast
EGG02691      46 VYVGNLSFFTTEEQIFELFSKIAPIKRIIMGLDRnsKTPCGFCFVEYYEPIEALGCLRYISGTKLDERIIRADLDPGY 123 Melampsora larici...
XP_001712269  38 VYVGNLSFHTREEQIWELFFRIGNIKRIIIGLNRynYTPCGFCFIEFYNLIDAKNCVFFFRGFKIEKRVIKIELDPGF 115 Hemiselmis anders...
EEY59954     162 LYVGNLSFFTSEAQIYELFSRVGHVKRVIMGLDRfkKTPCGFCFVEYSAHVEAEACSQFLSETKLDNRVVRCEMDGGF 239 Phytophthora infe...

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