Conserved Protein Domain Family
Casein_kappa
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pfam00997: Casein_kappa 
Kappa casein
Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.
Links
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Statistics
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PSSM-Id: 460021
Aligned: 15 rows
Threshold Bit Score: 168.798
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P02669        22 QEQNQEQRI---CCEKDERFFDDKIAKYIPIQYVLSRYPSYGLNYYQQRPVAL-INNQFLPYPYYAKPVAVRSPAQTLQW 97  sheep
XP_004766386  22 EVQNQEQPT---CRKNDESLFNQKIAKYIPFHYVLNNYPRYEPTYYPHIPVVP-INHQYVPYPFYAKPVAVRPHAQIPQW 97 
P33618        22 DIQNQEQTT---CRENEERLFHQVTAPYIPVHYVMNRYPQYEPSYYLRRQAVP-TLNPFMLNPYYVKPIVFKPNVQVPHW 97  rabbit
P06796        22 EIQNPDSNC---RGEKNDIVYDEQRVLYTPVRSVLN-FNQYEPNYYHYRPSLPaTASPYMYYPLVVRLLLLRSPAPISKW 97  house mouse
P19442        22 EVQNQEQPA---CCGNDERLFEQKKVLYLLSYPVLNNYLRTAPSYYQNRASVP-INNPYLCHLYYVPSFVLWAQGQIPKG 97  domestic guinea...
XP_004871808  21 EVPNQEQSA---CCENDERLFNQKKVLYILSHPVLNNYLHNARNYYQNRAVVP-INNPYKCDPYYAQSFVFRPQAPIPQW 96 
XP_017825992  21 EIQNQEQQA---CRENDERQLYQKIVPYIPIYYVPNSYPYYRTNWYQNRPAIA-INSPYVSRPYYPNP--VRPHAQVPQW 94 
P07498        21 EVQNQKQPA---CHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIA-INNPYVPRTYYANPAVVRPHAQIPQR 96  human
XP_023408995  21 EVQNQEESRlfqCLEKDERWFCQKAVKYIPNDYVLKSYYRYEPNYNQFRAAVP-INNPYLIYLYPAKQVAVRPHTQIPQW 99  African savanna...
XP_014323818  21 EVQNQEQQT---CCETDKRLFDQSTVKYIPIHYVWKSYPHIAPNYYQYRPAVP-INNQYMPYPCYTKPVSIRPHAQIPQW 96  little brown bat

P02669        98 QVLPNAvpakscqdQPTAMARHPHPHLSFMAIPPKKDQDKTEIPAINTIASAEPTVhsTPTTEAVVNAVDNPEASSESIA 177 sheep
XP_004766386  98 QVLPNA--------FPPTVVRPPHLHPSLNTITPKKIQAKTGIPTINTIASVEPTF--IPTTEPTVNTVVTSDASSEFTI 167
P33618        98 QILPNI--------HQPKVGRHS--HPFFMAILPNKMQDKAVTPTTNTIAAVEPTP--IPTTEPVVSTEVIAEASPELII 165 rabbit
P06796        98 QSMPNF--------PQSAGVPYAIPNPSFLAMPTNENQDNTAIPTIDPITPIVSTP--VPTMESIVNTVANPEASTVSI- 166 house mouse
P19442        98 PVSTDI--------HQSTMQYHQAKHPSFMAILSKKILGKATILSTDAIAAPEQTP--VSAAQPTVSAGDTPEVSSQFI- 166 domestic guinea...
XP_004871808  97 SVLTNA--------HQFTMLHRPTKYPSFMVIPARKIPEEAAIPTTDTMATLEPTP--VPVAEPATNTADFSGASAKFV- 165
XP_017825992  95 QYLPNT--------HPATMVRHPKQHPSFIAIPPKKIQDKIIIPTINTITTVEPTP--TPTTVTVVKRVITPEASSESII 164
P07498        97 QYLPNS--------HPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTP--APATEPTVDSVVTPEAFSESII 166 human
XP_023408995 100 QVPSNI--------YPSPSVPHTYLKPPFIVIPPKKTQDKPIIPPTGTVASIEATV------EPKVNTVVNAEASSEFIA 165 African savanna...
XP_014323818  97 QALPNI--------YPPTLVRHPYLRPSLFAIPPKKNQDKAVIPTANTVPADEPTL--IPPSestpplfavppkknqdka 166 little brown bat

P02669       178 -SAPETNTAQVTSTE 191 sheep
XP_004766386 168 tSTPETTTIPVTSPT 182
P33618       166 --SPETTTEATAASA 178 rabbit
P06796       167 -NTPETTTVPVSSTA 180 house mouse
P19442       167 -DTPDTSVLAEEARE 180 domestic guinea pig
XP_004871808 166 -HTPETSTVPATSPM 179
XP_017825992 165 tSTPETTTVSVTTPT 179
P07498       167 tSTPETTTVAVTPPT 181 human
XP_023408995 166 tNTPEATTVPVISPQ 180 African savanna elephant
XP_014323818 167 vipivntvpadeatl 181 little brown bat
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