Conserved Protein Domain Family
Cyclophilin_PPIL3_like
?
cd01928: Cyclophilin_PPIL3_like 
Cyclophilin_PPIL3_like. Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a histidine at this position. The exact function of the protein is not known.
Links
?
Statistics
?
PSSM-Id: 238909
Aligned: 12 rows
Threshold Bit Score: 240.031
Created: 14-Oct-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on similarity to related proteins with known structure and function.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  ##    #                               
AAH07693       1 MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGn-----SIWGKKFEDEy 75  human
CAE75684       1 MSVTLHTTLGDLKIEIFCESVPKTAENFLALCASGYYNASPFHRMIPSFMVQTGAPANPSPPEnpkggrSIYGPTFEDEi 80  Neurospora crassa
XP_493698      1 MSVTLHTNLGDIKCEVFCDQAPRTAENFLALCASGYYDGTIFHRNIKGFMIQGGDPTGTGKGGt-----SIWGKKFADEf 75  Japanese rice
AAO42397       1 MSVTLHTNLGDIKCEIFCDEVPKSAENFLALCASGYYDGTIFHRNIKGFMIQGGDPKGTGKGGt-----SIWGKKFNDEi 75  thale cress
NP_701030      1 MSLSIHTNYGDIKIELFCYEVPKTCKNFLALCASGYYDNTKFHKNIKGFAIQGGDPTNTGKGGq-----SIYGKYFEDEf 75  Plasmodium falc...
AAD43979       1 MSVRIITNYGDLKFELFCSQCPKACKNFLALSASGYYKNTIFHKNIKGFIIQGGDPTGTGKGGe-----SIYGRYFDDEi 75  Cryptosporidium...
AAM29546       1 MSVTLHTDVGDLKIELFCDACPKACENFLALCASDYYSGCVFIRNIKGFIVQTGDPTNTGKNGq-----SIWGQKFDDEf 75  fruit fly
NP_001002146   1 MAVTLHTDLGDMKIELFCEKAPKSCENFLALCAGGFYNGCIFHRNIKGFIVQTGDPTGTGKGGt-----SIWGRKFEDEf 75  zebrafish
AAH61645       1 MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTGRGGs-----SIWAKKFEDEy 75  house mouse
EAK83307       1 MSVTLHTNVGDIKVEVFCDATPRAAENFLGHCAAGTYNDVKWHRNIKSFMIQTGDPTGTGKGGq-----SIWGKPFADEi 75  Ustilago maydis...
AAF89247       1 MSVVISTTRGSLLIHLRYTDCPKACFNFLALCASSYYDGCLFHRCVTNAFVLTGDPTGTGKGGes--vfAPEQRYFDDEg 78  Trypanosoma cruzi
P52017         1 MSVTLHTTSGDIKIELYVDDAPKACENFLALCASDYYNGCIFHRNIKDFMVQTGDPTHSGKGGe-----SIWGGPFEDEf 75  nematode

Feature 1                                    # #       #                                         
AAH07693      76 seyLKHNVRGVVSMANNGPn----TNGSQFFITYGKQPHLDMKYTVFGKVIDg---LETLDELeklpvn--ektyrPLNE 146 human
CAE75684      81 rpvLRHNERGIVSMANKGPn----TNGSQFFILFDKAPHLDGLNTVFGKLIG----DESLQTLakleglevdkknrIKEE 152 Neurospora crassa
XP_493698     76 resLKHNARGVMSMANSGPn----TNGSQFFITYAKQPHLNGHYTVFAKVIHg---FEVLDLMekaqt---gpgdrPLAE 145 Japanese rice
AAO42397      76 rdsLKHNARGMLSMANSGPn----TNGSQFFITYAKQPHLNGLYTIFGKVIHg---FEVLDIMektqt---gpgdrPLAE 145 thale cress
NP_701030     76 dstLKHDKRGIVSMANKGKp---nTNGSQFFITYSRQPHLNGIYPVFGKVIDg---MDVLSVLenepv---geksrPIKD 146 Plasmodium falc...
AAD43979      76 ypeLKYDRRGILSMASKGAskkpnTNGSQFFITYSSLPQLNGEYVIFGKLIDg---FETLNTLencps---dkshkPIDE 149 Cryptosporidium...
AAM29546      76 ketIKHTDRGMVSMANNGPn----ANASQFFITYAAQPNLDLKYTLFGRVIDg---FDALDELeklpvn--pknyrPHVD 146 fruit fly
NP_001002146  76 sehLKHNVRGVVAMANNGPn----TNASQFFFTYAKQPHLDMKYTVFGKIIDg---LETLDEIeklpvn--ektfrPLND 146 zebrafish
AAH61645      76 seyLKHNVRGVVSMANNGPn----TNGSQFFITYGKQPHLDMKYTVFGKVIDg---LETLDELeklpvn--ektyrPLND 146 house mouse
EAK83307      76 rssLKFDRRGIVACANAGPd----TNKSQFFITYAKQPHLDGKYTIIGKVIDgaedGGTLDAMeaipv---daknrPTSE 148 Ustilago maydis...
AAF89247      79 lgtVHHDSRGVVSMAHRGNkp--nTNASQFFIIFQPCPSLDTKHTAFGCVDLawndGESERTLk------------KLEE 144 Trypanosoma cruzi
P52017        76 vsaLKHDSRGCVSMANNGPd----SNRSQFFITYAKQAHLDMKYTLFGKVIDg---FDTLEEIetikv---dnkyrPLVQ 145 nematode

Feature 1                
AAH07693     147 VHIKDITI 154 human
CAE75684     153 VRIERVTV 160 Neurospora crassa
XP_493698    146 IRLNRVTI 153 Japanese rice
AAO42397     146 IRLNRVTI 153 thale cress
NP_701030    147 IIIETITI 154 Plasmodium falciparum 3D7
AAD43979     150 IIIKDIVI 157 Cryptosporidium parvum
AAM29546     147 KKINGVTI 154 fruit fly
NP_001002146 147 VRIKDVTI 154 zebrafish
AAH61645     147 VHIKDITI 154 house mouse
EAK83307     149 IRMTGVTV 156 Ustilago maydis 521
AAF89247     145 LRVDDKYN 152 Trypanosoma cruzi
P52017       146 QKIQNVTI 153 nematode

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap