pfam15313: HEXIM (this model, PSSM-Id:405901 is obsolete and has been replaced by 464638)
Hexamethylene bis-acetamide-inducible protein
HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",