4N9F


Conserved Protein Domain Family
CBF_beta

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pfam02312: CBF_beta 
Core binding factor beta subunit
Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.
Statistics
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PSSM-Id: 396750
Aligned: 19 rows
Threshold Bit Score: 180.631
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4N9F_0         1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQ--GEQR 78 
Q2F7Z1         1 MPRVVPDQRSKFENDELFRKLGRDSELRYTGYRDRAQEERQMRFVNSCREGHAQLSFVATGTNLHLQFYPNSWS--ETTD 78  purple sea urchin
Q4H3S2         5 MPRVVSDQRATYDSNELFRRLSRDTEIKYTGYRDRGTEERQLRFQNSCRAGRAEIAFVGSGTNFTLQFYPWSVE--GGQG 82  vase tunicate
1_pfamImport   1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQ--GEQR 78 
XP_008109947   1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQ--GEQR 78 
ACF96954       1 MPRVVPEQKQKFENDEMFRKLARESEIKYTGYRDRSHEERVVRFQTEIRDGQSNVAYVASGTNLTLHF-PKAED--GFIR 77 
XP_002602848   1 MPRVVPDQKAKFENDEFFRKLGRECEIKYTGFRDRSHEERVVRFQADLREGHAEIAFVATGTNLALQFSPSA-------D 73 
EFO96078       1 MKRTTNDQQTSFQSDYFLTQLAHFTEAKFSLFEHAPLVERRERFRNHIERDEMPLTFCKMGINIPVKLETSQTI------ 74 
CAP20507       1 MKRTTNDQQGSFQTDYFLTQLSNFTEAKFSLFEHAPANERRDRFRNHIERDEMPLTFCKMGINIPVKLEWCQTI------ 74 
XP_003387352   1 MPRVFPDQQKKFESEEVFKKLSQDSDIKYTGFKDKPHDERRQRFIQDLSEGHSILTFVSTGTNLTLLFCSKALSddRTAE 80 
4N9F_0        79 QTPsREYVDLEREAGKV----------------YLKAPMILNGVCVIWKGWIDLQRLDGMGCLE-FDEERAQQEDALAQQ 141
Q2F7Z1        79 RKPtKEYVDFDKEIGKV----------------CLKSQFILNGVCVIWRGYIDLNRLDGVGHVE-FDSQRAKEEDEIYRA 141 purple sea urchin
Q4H3S2        83 ITPpKDYVNFDREPGKV----------------HLKAPFILNGVCVCWKGWMDLHRLEGMGSIV-YDEERAQLEATRQGG 145 vase tunicate
1_pfamImport  79 QTPsREYVDLEREAGKVgnislrfkilwvlgkkYTRMDVTENARCLIGK-------------------QSSKQEDALAQQ 139
XP_008109947  79 QTPtREYVDFEREGGKV----------------YLKAPMILNGVCVIWKGWIDLQRLDGMGCLE-FDEERAQQEDALAQQ 141
ACF96954      78 S----EFLDFDREPGKV----------------HIKSHFILNGVCIIFKGWIDLQRLDGIGYIE-YDEEKARKEDKIMRE 136
XP_002602848  74 KAPsKEYVDFEKEPGKV----------------HLQARFILNGVCVRWKGWIDLQRLDGIGSIE-FDEEKAKIEEQQMKE 136
EFO96078      75 ----GNEINFRSRP------------------------FVFNGIWVKVVGTMNTETLDGRVRFErFQRETR------VPR 120
CAP20507      75 ----GNEINFRSRP------------------------FLFNGIWVKVFGTMNSESLDGRVRFErFQREKS-----VHHR 121
XP_003387352  81 HKPsRENVDFESELGKV----------------HLSSRFIMNGVCVKWIGWVDLETLTGKAKLV-FDDQNAKIEDEVMRQ 143
4N9F_0       142 AFEEAR--RRTREFEDRDRSHREEMEVR 167
Q2F7Z1       142 TMEQQN--RRLREFEERTMLHRKEFEQQ 167 purple sea urchin
Q4H3S2       146 SMQQHM--HKTSNPKTQNHKHPATGGSS 171 vase tunicate
1_pfamImport 140 AFEEAR--RRTREFEDRDRSHREEMEAR 165
XP_008109947 142 AFEEAR--RRTREFEDRDRSHREEMEVR 167
ACF96954     137 TLEQAK--QRLAEFEERQRQWREEQQRK 162
XP_002602848 137 AMEQAT--RRQREFEERQQAHRDQMERR 162
EFO96078     121 VISQLTdiKRIPEVEEETIGLTEAEMAA 148
CAP20507     122 VLTETK--VKFPEVEEEPIGLTDAEIAA 147
XP_003387352 144 VMKETQ--ERVRLFEESQRKWQEQRQPH 169
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