4JND,6B67,3NMN,2POM


Conserved Protein Domain Family
PP2C

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pfam00481: PP2C 
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Protein phosphatase 2C
Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.
Statistics
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PSSM-Id: 395385
Aligned: 28 rows
Threshold Bit Score: 161.735
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JND_A        166 IHVSGDQLKGQRHKQEDRFLAYPNGQYmd-----rgEDPISVLAVFDGHGGHECSQYAAGHLWe----TWLEVRKSRDPS 236  Caenorhabditi...
P25646        108 YARRFPEGNYWKHKLSTFEKFYNKFIKncnskqellLMKEGDSAILGQNGGRMIFDKMGNIIDkiallTELDRLRLFYGF 187  Saccharomyces...
Q12511        181 EDGKSIEKDLYFFGIFDGHGGPFTSEKl-------sKDLVRYVAYQLGQVYDQNKTVFHSDPN-----QLIDSAISKGFL 248  Saccharomyces...
O14156         92 DGHGGTECSEFLSTNLGKIIENQd-----------lNDTEKILKEVHSVGGYMAGLKPPFSLR-----TVLQSRDEDLLW 155  Schizosacchar...
P14605       1032 SDISAGKNNRVLKFVYDNLASCLAHEIna------aDSSSEQICNALRRGFLRLNKKLGNVIH-------YDLRKSSEGD 1098 Schizosacchar...
P49606       1742 FGLFDGRGHGAHVGSRIAHHLAEWSg---------hRLSWEFQKHQNEMTAEPVSVPDALRRA------FLRLQKDYADA 1806 Ustilago mayd...
P08678       1373 RDVTFERFRGNDDECLLCLHDSKNQNAdy-----ghNISRIVRDIYDKILIRQLERYGDETDDn----IKTALRFSFLQL 1443 Saccharomyces...
Q01631       1568 FDLVVPRLGSVETDTLVALFDGK-ELStg-----gsKIAKFLYEEFSRLFILELEKVKGKPNEn----PADALRRTFLSV 1637 Neurospora cr...
CAP59981     1450 iDLVVPRFNSNDSETLLGLFDGQALSSgg------sKIAKYLQENFGHIFSQELRDLKNTENP------ADALRRSFLSL 1517
XP_003709992 1306 vDLVVPRFNASETETLLGLFDGQALSSgg------sKIAKYLHENFGQILATELRALKTGLKEt----PEDALRRAFLAL 1375
4JND_A        237 D--SLEDQLRKSLELldERMTVRSv--------kECWKGGSTAVCCAIDMDQk------lMALAWLGDSPGYVMSNIEFR 300  Caenorhabditi...
P25646        188 ArfDLDQCCGLGTAAgsTASSIFLypyd---dpnAPIDEGKDDDSWIISHSGll-----kLIVTQVGDSKIILCDQDGIA 259  Saccharomyces...
Q12511        249 K--LDNDLVIESFRKlfQDPNNTNia------ntLPAISGSCALLSLYNSTNs------iLKVAVTGDSRALICGLDNEG 314  Saccharomyces...
O14156        156 R-----ARLYYSFLQadMDYLTNYarps--pdsaVPGAVGTVAIITSKNNLSywesdsyiIHLAHVGDTRALLCDSRTGR 228  Schizosacchar...
P14605       1099 -----VDSNYVTTMN--ISEKGYSmd-------sSCLDIGVSIILVYVRDTR--------AFVANVGTSMAIMSTRNDSE 1156 Schizosacchar...
P49606       1807 LinDGSRKLSEAHAEaaADVTRSSapaiaaasnkHDWRAGASAILAYVVDHT--------LYIANAGDALAVMSRNGGTA 1878 Ustilago mayd...
P08678       1444 N--KEINGMLNSVDN--GADVANls--------yADLLSGACSTVIYIRGKK--------LFAANLGDCMAILSKNNGDY 1503 Saccharomyces...
Q01631       1638 N--KLLMSLSNSADEr-GLDSHPSrnyahtvltkEDLNSGCVATVAYLSELK--------LYVANVGDVQGMLIQANGSF 1706 Neurospora cr...
CAP59981     1518 N--KDLIAAGNTHTEdrSLMVHRGstapl-vlsrEDMNSGGVATIVYIQNQD--------LYVANVGDVQAMIIKSDSTH 1586
XP_003709992 1376 N--KELVTIAIQHSEdrPSVPHRSgsqahvilnkEDLNSGGVATVVYLQGQD--------LYVANVGDAQAMIIQSDQTH 1445
4JND_A        301 -----QLTRGHSPSDEREARRVEEAGGQLFVig-gELRVNGV-LNLTRALGDVPGRP----------------------- 350  Caenorhabditi...
P25646        260 h----ALTTTHHINSSRERHRLSIDPSRLDPdafgETRFLNN-FANTRSFGDVAGKPygissepd--------------- 319  Saccharomyces...
Q12511        315 nwtvkSLSTDQTGDNLDEVRRIRKEHPGEPNvi-rNGRILGS-LQPSRAFGDYRYKIkevdgkplsdlpevaklyfrrep 392  Saccharomyces...
O14156        229 a---hRLTFQHHPADVEEARRLRRYNMGFSRd--sFGQKRFAwVANTRSFGDGYKLKk---------------------- 281  Schizosacchar...
P14605       1157 p---tTLSVMHDVYNRDEIRRIVDSCGFIS------GEIKST---TTRAIGRLSQFP----------------------- 1201 Schizosacchar...
P49606       1879 h----LISNKHEPFDRAEIERIRSAEGWVSl----RGYVNDM-LDVSRSFGYFHLFP----------------------- 1926 Ustilago mayd...
P08678       1504 q----TLTKQHLPTKREEYERIRISGGYVN-----NGKLDGV-VDVSRAVGFFDLLP----------------------- 1550 Saccharomyces...
Q01631       1707 k----MLTKKHDPADPVERSRIRNAGGWVSR----NGRLNDV-LNVSRAFGYTELLP----------------------- 1754 Neurospora cr...
CAP59981     1587 v----MLTKKHDPADPNERTRIREAGGWVSR----NGRLNDL-LEVSRAFGYLDLMP----------------------- 1634
XP_003709992 1446 k----MLTRKHDPAEPTERSRIREAGGWVSR----NGKLNDQ-LGVSRAFGYVDLMP----------------------- 1493
4JND_A        351 -------MISNEPETC--QVPIESS-DYLVLLACDGISDVFNERDLYQLVEAFANDypv--edYAELSRFICTKAIEAGS 418  Caenorhabditi...
P25646        320 ifsflvgNTLHLPRSErsKLPFNGD-ECFLALVTDGITNKLADQEVVDLITSTVNSwglkkatPQFVAEETIKFIQAIAT 398  Saccharomyces...
Q12511        393 rdfktppYVTAEPVIT--SAKIGEN-TKFMVMGSDGLFELLTNEEIASLVIRWMDKn-------MNLAPVKAEPGKLPKV 462  Saccharomyces...
O14156        282 ------lGVVAEPQLT--SIHSLRDdWSFLTLLSDGITDVVSDDEVVDIIKLSES--------PQDAANNIIRYAQNVGA 345  Schizosacchar...
P14605       1202 -------GVQAVPYVN--VQYLSEL-NEFIILANQEFWSVLSKRTVIDVVRANRHS-------PLLASTKLRDYAIAYGA 1264 Schizosacchar...
P49606       1927 -------IVNAAPAVT--TVQLTDS-DEFVIIANRTLWQYVSYQTAVDIARTQRND-------PMIAAQKLRDFAISYGA 1989 Ustilago mayd...
P08678       1551 -------HIHASPDIS--VVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTD-------PLRAAAELKDHAMAYGC 1613 Saccharomyces...
Q01631       1755 -------AVQAAPDIT--EHTIDDK-DETVLIASKELWEHLRPELIVDVARECRSD-------LMKASQKLRDLAIAYGS 1817 Neurospora cr...
CAP59981     1635 -------AVQSAPNIE--KHTIGEH-DEMILIATREVWEYLPKDVLVDVTRSVRQD-------PMRAAQKVRDLAMAYGC 1697
XP_003709992 1494 -------AVQAAPHVS--HVAIREQ-DEMILLATSELWEHLAPELIVDIARQERGD-------LMRATQKLRDLAIAYGS 1556
4JND_A        419 ADNV 422  Caenorhabditis elegans
P25646        399 KHSD 402  Saccharomyces cerevisiae S288C
Q12511        463 IDVS 466  Saccharomyces cerevisiae S288C
O14156        346 VDDI 349  Schizosaccharomyces pombe 972h-
P14605       1265 EKNV 1268 Schizosaccharomyces pombe 972h-
P49606       1990 EESI 1993 Ustilago maydis 521
P08678       1614 TENI 1617 Saccharomyces cerevisiae S288C
Q01631       1818 TNKL 1821 Neurospora crassa OR74A
CAP59981     1698 SNKM 1701
XP_003709992 1557 TNKI 1560
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