3ODX,7CSP,3MPX


Conserved Protein Domain Family
RhoGEF

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pfam00621: RhoGEF 
RhoGEF domain
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.
Statistics
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PSSM-Id: 459876
Aligned: 157 rows
Threshold Bit Score: 89.2811
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ODX_B         71 VISELLVTEAAHVRMLRVLHdlffqpm---------aeclffpLEELQnIFPSLDELIEVHsLFLDrlMK---------- 131  human
Q55G61        387 ALEEMLKVERGYVQDMTTLIdvfkkpf---------sedtifpKQHLFtLFCNIEELRELH--QQF--LNdiekk----- 448  Dictyostelium...
XP_001625726  701 IAKELLNTERTYVKDLEVITiafrevv---------sspgvlpEATKKlLFSTIDPIYDFH-CA-F--LSeleermtlwd 767 
CAF90550      633 IAKEILTTERTYLKDLEVITvwfrsav---------ikenampEGLMTlLFSNIDPIYEFH-RD-F--FKeldqrlalwe 699 
Q5RAB8        544 IAKEVSTTERTYLKDLEVITswfqsav---------skedampEALKSlIFPNFEPLHKFH-TN-F--LKeieqrlalwe 610  Sumatran oran...
EDO48232        7 ITHEILSTERTFVESLRLAYedcygsv---------kaaevvpESTLNeIFKDLGNIYHLD-VK-F--LQeleerm---- 69  
P52734        376 IANELLQTEKAYVSRLHLLDqvfcarlle-----earnrssfpADVVHgIFSNICSIYCFH-QQFL--LPele------- 440  house mouse
AAI25227       84 IAKEIMSSEKVFVDVLKLLHidfrdavaha---srqlgkpvieDRILNqILYYLPQLYELN-RD-L--LKeleerm---- 152 
3MPX_A         26 IAQELLSSEKAYVEXLQHLNldfhgavxralddxdhegrdtlaREELRqGLSELPAIHDLH--QGI--LEele------- 94   human
CAG02033      955 VAKDLVDSERLHVSVLKHLQedfrsavmea---egeegepvleEQQLGeILGVLPQVYALH--SSI--LTele------- 1020
3ODX_B        132 ----------R-RQESGYLIEEIGDV-LLARFDGAEGswfqkiSSRFCSRQSFALEQLKAkqrkdp----rfcafVQEAE 195  human
Q55G61        449 -----feptnGkPADLNI-----GDL-FLPFM----Gsfq-klYELYINNYEKAFALTRYfkinpnyqdiqksiyQKE-- 510  Dictyostelium...
XP_001625726  768 -qsfttstgtEpR----I-----GDL-MHKNM----Kqi--krYVHHLKKHDEVMLELEAatkkfkqf--elaykefE-- 826 
CAF90550      700 grsnahvkgdCqR----I-----GDV-MLRNM----Cal--keFTSYLQKHDEVLTELEKatkrmkkl--etvykefE-- 759 
Q5RAB8        611 -grsnaqirdYqR----I-----GDV-MLKNI----Qgm--khLAVHLWKHSEALEALENgikssrrl--enfcrdfE-- 669  Sumatran oran...
EDO48232       70 -----ktwedHeR----I-----GDI-VKKYG----Hfl--kmYTTYINNYDKAANVLQEtmkenpqf--aelvlefQ-- 124 
P52734        441 -----------krmEEWDRYPRIGDI-LQKLAPFLKM------YGEYVKNFDRAVELVNTwterst----qfkviIHEVQ 498  house mouse
AAI25227      153 -----lhwteQqR----I-----ADI-FVKKG----Pyl--kmYSTYIKEFDKNIALLDEqckknpgf--aavvrefE-- 207 
3MPX_A         95 -----------erlSNWESQQKVADV-FLAREQGFDH------HATHILQFDRYLGLLSEnclhsprlaaavrefEQSVQ 156  human
CAG02033     1021 -----------eriSQWEENQSMVDViLSRREDFRV-------FDTYISEYDRSMCLLEEscrdnlafasv---vkkfek 1079
3ODX_B        196 SRPRcRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCREILHHVN 254  human
Q55G61        511 KDIRcRHLDFGSFLVIPIQRLPRYIVLLKEMEKHTPTDNpDFNFIALSLVQLQDLTLYLN 570  Dictyostelium discoideum AX4
XP_001625726  827 TQKIcY-LPLNAFLLKPSQRLLHYRFLLERLLKYCVRDSeDSQDIQGALEELVGAVKSTE 885 
CAF90550      760 LQKVcY-LPLNTFLLKPIQRLMHYKLILERLCKHYSPTHrDHDDCKEALKEVADIAAQLQ 818 
Q5RAB8        670 LQKVcY-LPLNTFLLRPLHRHMHYKQVLERLCKHHPPSHaDFRDCRAALAGITEMVAQLH 728  Sumatran orangutan
EDO48232      125 ASKKcKGLMLNSFMLKPVQRIPSYRLLLIDYLKHLPPESaEYQDIKVALDIVSEVATHIN 184 
P52734        499 KEEAcGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSpDSKDAQKSLELIATAAEHSN 558  house mouse
AAI25227      208 MSPRcANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAgDYRDTQDALAVVIEVANHAN 267 
3MPX_A        157 G----GSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSaEYDNTQGALSLISKVTDRAN 212  human
CAG02033     1080 rsldgAEVPLKHQLLQIIVRVLQYRMLLTDYLNNLSPDSkEYEDTQAALVIVSEVSDQAS 1139
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