Conserved Protein Domain Family
pbuX

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TIGR03173: pbuX 
xanthine permease
All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.
Statistics
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PSSM-Id: 274468
Aligned: 40 rows
Threshold Bit Score: 345.662
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011706031  28 AVTHLLAIFVPMVTPALIVGGALGL-------STETTAYLVSMAMIASGIGTWLQVNR-YGPIGSGLLSIQSVNFSFVTV 99  Aeromonas hydro...
WP_011948105  27 GLQHIFAAFGGIIVVPIVISAALGF-------DAQTSTALISSAILAAGVATFIQSRG-IGPIGARVACIMGTDFTFVAP 98  Clostridium bot...
WP_011218942  26 ALQHMLASIGGIVAVPLIVGTSIGL-------PVDEVVTLINAALLASGIVTIAQCVG-IGPVGIRLPVVMGSSFAFLGV 97  Photobacterium ...
WP_014546334  23 GLQHVLAMFVSNITPIIILANVVGI-------EKGLTASLIQNCMIIASIGTLIQLYP-VWKIGSRLPIVMGISFTFLSV 94  Fibrobacter suc...
WP_007052123  31 GLQHVMAMFVANLAPIFIVASAAKM-------TPAQSATIIQSGLLVAGLGTCLQLYG-AWLIGSRLPMVTGISFTYVAA 102 Bifidobacterium
WP_016614354  25 GLQHVVAAVVGIVTPGIMIAKVCQL-------SPSDTTILIQTSLIFSAVATLIQLFPiFGKVGSRLPVMMGASFAYVPI 97  Enterococcus fa...
WP_011046623  28 GIQHVLAMFVSNVTPAIIVAGAAGFgfgsnspDFPELLYLIQMSMLFAGVATLLQTVT-LGPVGAGLPIVQGTSFAFLPI 106 Ruegeria pomeroyi
KEY22966      15 GFQHVLV--SNVWLDPVFVAGAIGL-------PIALSSNMINAIFIVSGLVTLVQATR-LV----RLPVVQGPSAAFDAL 80  Bifidobacterium...
WP_002380593  28 GIQHVLAM--DVYVVPVIIASIIGI-------STAQTSSLIQATFIAAGLATIIQS-----HFCMRLPVAQGPSFIPIGA 93  Enterococcus fa...
WP_011366785  26 GLQHVLAM--DVYIAPFVMAGLLSL-------SVPETATFIQMTFVAAGLATLIQA-----GFGIRLPVMQGPSYVPIGA 91  Desulfovibrio a...
WP_011706031 100 MIALGSam-kKDG---LheelivSTLLGVSFVGAFLVMG--SS---FVLPYLK-RVI-TPTVSGVVVLMIGLSLIKVGI- 167 Aeromonas hydro...
WP_011948105  99 AIAVGG----KFG---L------SGIFGATILGAGIVII--LS---FFVKPLM-KLF-PPIVTGTVVSLIGLTLLPVSI- 157 Clostridium bot...
WP_011218942  98 AISIGK----EGG---V------SSIMGASLVGSFVVIL--AS---FYMDKIR-KLF-PTVVSGVVVTLIGLTILPVAM- 156 Photobacterium ...
WP_014546334  95 SISIGV----SQG---M------GTLMGAVIVGGIVEGL--LG---LCAKYWL-KLI-PHIVAATVVTSIGFSLLPIGA- 153 Fibrobacter suc...
WP_007052123 103 AVAICA----DKG---Y------GAVVGAVMVGGLLELV--LG---LTAKYWR-RFV-PPIVSAIVVTSIGFSLLNVGA- 161 Bifidobacterium
WP_016614354  98 LMAIGA----DFG---I------AAIFGSQLVGSILVII--VG---LFIKKIR-VLF-PPLVTGTVILSIGLSLFPVAI- 156 Enterococcus fa...
WP_011046623 107 MIPLVA----GKGvdaL------AALFGGAILGGLFHFC--LG---FFIGRIR-FAL-PPLVTGLVVTMIGLALVKVGI- 168 Ruegeria pomeroyi
KEY22966      81 MIAAGTagmlGAA---S------SSI---LIASLVFLLLc-LT---GVIERMR-FLF-SPMISGVVIFMVGVSLSGFTL- 141 Bifidobacterium...
WP_002380593  94 IAGIYFan-nQQGn-gW------GAVLGASLVGAIVVIIlgFT---GIFNRLItKFV-PPIVGGTIIFVVGLSLMPVALs 161 Enterococcus fa...
WP_011366785  92 LAAIGN----SLG---L------GAMFGSLLPGALVMTL--LGkplRVFSRIV-RFFiPPLVGGTVIVIVGIALMPVAL- 154 Desulfovibrio a...
WP_011706031 168 IDFGGG-F-SAmssGTFGKY-ENIGLGLL---VLCVIVAF-NCS-------KSPLLRMSG-IAIGLLVGYAVALMLGMVD 232 Aeromonas hydro...
WP_011948105 158 DWAAGG-A-GS---ANYGSL-KNISIALF---IMIVTLLL-NHY-------GKGLVSSAS-ILIGMIVGYIICIPLEMVD 219 Clostridium bot...
WP_011218942 157 NWVGDApA-VS---EEFATL-PKLFLAMI---SLAIVIAV-SVY-------CKGAIAASA-IVIGLAGGYIVALSMGMVN 219 Photobacterium ...
WP_014546334 154 NSFAGG-Q-GA---ADFGSA-QNWIVGSV---TLLTCLLT-QVF-------AKGFLRSLS-VLVGLIVGYILALCMGMVD 215 Fibrobacter suc...
WP_007052123 162 TSFGGG-S-GA---KDFGSW-QNLTLGLI---SLVACLAF-QLL-------MKGTAKQLS-VLFGLVVGYVAAICMGKVD 223 Bifidobacterium
WP_016614354 157 KYMAGG-A-GS---ADFGSA-RNWLVALL---TFAIVFYF-NYF-------AKGFLKLSA-ILNGMVIGYLISLALGMVS 218 Enterococcus fa...
WP_011046623 169 QYAAGG-V-PAigtPEYGSA-LNWSAALV---VILVTLGL-KFF-------ARGMLSVSA-VLLGLIVGYVYALMVGMVT 233 Ruegeria pomeroyi
KEY22966     142 SEFLGG-ApGD---KTFADP-HILTVSIL---TTAIVLVL-SLL-------GKGLLKSFS-FLIALVVGTVVAAAFGMVD 204 Bifidobacterium...
WP_002380593 162 DNIYH----------AKGELgQNILLAFIaagTLIFFALLgSAL-------KKGRIFRVSsVILALLFGSIAAQLLGVLD 224 Enterococcus fa...
WP_011366785 155 KGCYG----------YFGDP-AHNAVVAL---VSAAVLVV-LTVagsrpgrFNQVVRMGS-VVFSMAAGTLTAAAFGMVN 218 Desulfovibrio a...
WP_011706031 233 FSAL----ENLPLITVPVP--FKYGF-SFDLHAFVLAGTIYLLSVLEAVGDITAT-A-MV-S----HRQIQgpefQKRLS 298 Aeromonas hydro...
WP_011948105 220 FSSV----SQASWVSLPKI--FGYGI-TFNLQVLLPFIPAYFVTIIGTVGCLKAI-T-EV-S----GIKAD----EKPIT 281 Clostridium bot...
WP_011218942 220 LEQV----ASAEWISGPEP--FKYGF-TFSFGAIISMSLVYIVVIAEATGDFMAL-G-SN-C----HAKVT----GRDLK 281 Photobacterium ...
WP_014546334 216 FSGI----TNNGFFALPKF--LPF-TpEFNLGAILSVIAIYLVSATETVGDSSALcS-GA-L----KRQIH----KVEMG 278 Fibrobacter suc...
WP_007052123 224 FSGF----QNLAIVSVPQF--MPF-KpEFDWGSIISIGLLYVVSSVEVLGDTAAL-T-KVgL----NRTPT----ERETA 286 Bifidobacterium
WP_016614354 219 FEPV----QNAKIVQVITP--FHFGL-DFQLVPIFTLVVMFIVDAVQAIGQFTAT-TvGA-M----DRDAT----DEELS 281 Enterococcus fa...
WP_011046623 234 FEAIgtswSRAAGFALPVP--FKYGF-EFSLAAVIGFAMMAVVSAIETVGD---V-S-GI-TkggaGREAS----DNEIA 300 Ruegeria pomeroyi
KEY22966     205 FSPV----ASKGWLGLPTF--LPYGPfTFDWKIFIPFFIAYMVAVMEALGVYQAA-S-EI-Q----GTSLE----RKQVR 267 Bifidobacterium...
WP_002380593 225 LSAV----SKAAWFSLPQLplVNFSF-QFDWSAIATMLVIYLVLMAETTGTWFAV-S-HV-V----AEPLT----EEKIN 288 Enterococcus fa...
WP_011366785 219 FDSV----AAAPWLALPVI--FPYGTpHIDVSAALTLVFIYLVVLVETTGTWFAV-E-AV-T----GSRLD----DERIN 281 Desulfovibrio a...
WP_011706031 299 GGVLADGLVSVIASALGSLPLTTFAQNNGVIQMTG---VASRHVGKFIAVILVLLGLFPVVGRFFTTIPSPVMGGAMVIM 375 Aeromonas hydro...
WP_011948105 282 AGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTK---VASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVM 358 Clostridium bot...
WP_011218942 282 RGLLGDGLGSTLSAILTAMPLASFSQNVGIVGITG---VASRYVVAGTGGLLILGGLFPKLAALAVTIPKPVLGGVGFVM 358 Photobacterium ...
WP_014546334 279 GAISCDGFVSSISGLFGCTPITSFSQNVGLASLSG---VVNRFAIATSAGIMLLGGLFPPVGTLLTTIPQAVLGGCTIMM 355 Fibrobacter suc...
WP_007052123 287 GAIAGDGLISTVSGLFGCLPLTSFAQNIGLVAMTK---VVNRKVILSGGLILVLASFVPAIAEVFNSLPQAVLGGCTIMM 363 Bifidobacterium
WP_016614354 282 GGIMGSGFTNFIGSLFGSIPVATFGQNVGLVTVTK---VINKYVLVFASVILLIAGFVPKVAALLTTIPYAVIGGATISV 358 Enterococcus fa...
WP_011046623 301 GATYADGLGTAVAGLFGGFPNTSFSQNVGLIAMTG---VMSRHVVTIGALFLILCGLVPKVGAIIRTVPIEVLGGGVIVM 377 Ruegeria pomeroyi
KEY22966     268 YGLAGEAAGSAISSLIGGFTTTAYPQNVGLLNLTGedkLRTRTPVIIAAVLLLILGFVPKAGALLSVIPSAVVGGIFLPA 347 Bifidobacterium...
WP_002380593 289 RGVIGEGLGCLVSSFIGGTPVTSYSTNAGIISITG---VASRKVFVAAGAWFVLFGLSGKLSTLISAIPAPVIGGVFVVV 365 Enterococcus fa...
WP_011366785 282 GGTFGEGVGCFLGAMLGGTPVTGYSTNAGIIAITG---VASRWAIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAVI 358 Desulfovibrio a...
WP_011706031 376 FSMIAIAGGRIIISHGFDRR-ETLIVATSLGLGLGVSYDP-NVFKVLPAGIYMLV-ENP-ICAGGITAIIMNLVLP 447 Aeromonas hydrophila
WP_011948105 359 FGTVAAAGIQTLSSVKLNNR-NMLIIATSIGLGLGVTFRP-EFIAQLPESLKMIF-SSG-ISTGTIVALLLNVILK 430 Clostridium botulinum
WP_011218942 359 FGMIAYAGIRMLIKAADTKR-NALVICVGLASGLAVTFEP-RLIQHLPHDIANFF-HSG-ITTGTIITVLLHQILP 430 Photobacterium prof...
WP_014546334 356 FGSILFAGFGMIAKSGFS-QrNMIIVSLSLSTGLGFTSAS-QMFKIFPQIIQTIFaENC-VAVVFILAVVLNLVLP 428 Fibrobacter succino...
WP_007052123 364 FGNIILSGFQMIAEAGFT-QrNITIAALSLTIGIGFTQVS-DIFTQFPALFQQIFaSNC-IAVAFVVAVILNTVLP 436 Bifidobacterium
WP_016614354 359 FASISMTGIRMIASQEMTPR-NTGVVGTALAFGIGVTLST-GSLAGFPTWVTTIF-GNSeVILTTLVAVLLNVILK 431 Enterococcus faecalis
WP_011046623 378 FGMVVAAGVSMLSDVHWNRR-NMVIFAIALSVGLGLQLEP-GAVQHLPDTARILM-TSG-LLPAAVIAIVLNLILP 449 Ruegeria pomeroyi
KEY22966     348 AASLIVTGLRALRKVADDER-RQTVIGMSLLLGI---ALP-KALSGLTGGASVFF-GNN-IMVGVFSAIILNALFV 416 Bifidobacterium lon...
WP_002380593 366 CGIISVSGMKVMSDVTIHEK-EMYVIAVPIIMTLALTLLPkEFLETLPQFLQYLF-SSP-VATASIVAILLQAILP 438 Enterococcus faecalis
WP_011366785 359 CVVIAMNGFRVVRTVTLSER-NMLVMGLPILLTLAAVFMPaELRDRLPALVRYLV-ESG-IAVGAVSAVVLNLILP 431 Desulfovibrio alask...
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