Conserved Protein Domain Family
PRK06599

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PRK06599: PRK06599 
DNA topoisomerase I; Validated
Statistics
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PSSM-Id: 235840
Aligned: 111 rows
Threshold Bit Score: 913.859
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
19704404   11 NKLVIVESPAKAKTIEKILGSSYKVISSYGHIIDLPKTKIGVDVNNDFKPSYNTIKGKGEVIKQLKEASKKADKIYLASD 90 
21672896   13 RTLIVVESPSKAKTINKYLGDDYTVYASVGHIKDLPKKEIGIDFDNHYEPRYEVIAGKEKVVRQLKKLAGEADKVLIATD 92 
78187915   13 RTLIVVESPSKAKTINKYLGDGYTVFASVGHIKDLPKKEIGLDFDNHYEPRYEIIPGKEKVVRQLKKLASEADGVLIATD 92 
145220517  13 RTLIVVESPSKAKTINKYLGDGYAVFASVGHIKDLPKKEIGLDFDNHYEPSYEVIAGKDKVVRQLKKLSAEASAVMIATD 92 
189347904  13 RTLIVVESPSKAKTINKYLGDRYTVFASVGHIKDLPKREIGLDFDHNYEPRYEVIAGKEKVVRQLKKLAGEADSVLIATD 92 
189501368  13 KTLIVVESPSKAKTINKYLGSDYLVFASVGHIKDLPKKEIGLDFDNNYEPRYEVISGKEKVVRQLKKLAGQANDILIATD 92 
193213653  13 RTLIVVESPSKARTINKYLGDNYTVYASVGHIKDLPKKEIGIDFDNHYEPRYEVIAGKEKVVRQLKKLAGEANEVLIATD 92 
194335001  13 KTLIVVESPSKAKTINKYLGTGYKVFASVGHIKDLPKKEIGLDFDNNYEPRYEVIAGKEKVVRQLRKLAGEANDIMIATD 92 
194337811  13 RTLIVVESPSKAKTINKYLGDKYTVFASVGHIKDLPKKEIGLDFDHHYEPRYEIIPGKEKVVHQLKKLAAEADSILIATD 92 
78188059   13 KTLIVVESPSKAKTINKYLGSNYTVFASVGHIKDLPKKEIGLDFEHNYSPRYEIIPGKEKVVKQLKKLATEASNILIATD 92 
19704404   91 PDREGESIAWHIANTLKLDHNEKNRIEFHEITEKAIKDAVKNPRKINIARVNSQQARRILDRLVGYEISPFLWKLISPNT 170
21672896   93 PDREGEAIAWHISNEIDFAKKPVFRVLFNEITRNAIIEAIGHPQQIDYRLVRSQQTRQALDKIVGYKISPFLWNVVYRGL 172
78187915   93 PDREGEAIAWHIANEIGSTPKPVFRVMFNEITKSAILAAIDEPRQIDYRLVRSQQTRQGLDKIVGYRVSPFLWNVVMRGL 172
145220517  93 PDREGEAIAWHIANEIGKTSKPVTRVMFNEITKSAILEAIADPRQIDYKLVRSQQTRQGLDKIVGYRISPFLWNVVMRGL 172
189347904  93 PDREGEAIAWHISNEIEAARKPVFRVLFNEITKNAILAAISEPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGL 172
189501368  93 PDREGEAIAWHIANEVDAAQKPVHRVLFNEITKKAILEAINDPLQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVMRGL 172
193213653  93 PDREGEAIAWHISNEIEFAKKPVYRVLFNEITKNAIIESVNNPKQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVYRGL 172
194335001  93 PDREGEAIAWHIANEVEGARKPVQRVLFNEITKNAIIDAISHPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVFRGL 172
194337811  93 PDREGEAIAWHISKEIGVTSKPVSRVLFNEITKTAIIAAIQAPRQIDDRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGL 172
78188059   93 PDREGEAIAWHIANEIEHAKAPVARVLFNEVTKKAILEAIEKPRHIDLRLVHSQQTRQGLDKIVGYKISPFLWKVVLRGL 172
19704404  171 SAGRVQSVALKIICELEDKIKAFVPEKYWDVKGIF----DTKYSLNLYKIDNKKIDkLKDEKLLDRVKKDLKKK-YEVIS 245
21672896  173 SAGRVQSVVLRLICERETEIEAFTPQEYWTIYADFttenGETFRTKLVKVNGEKPD-ITSGEQAEAIASAIQGRlFAISE 251
78187915  173 SAGRVQSVALRLICEREVEINNFEVQEYWTIAADFitegKETFRARLVKLEGKKPE-LSNQAEAEAAADLVQKGsYTLLD 251
145220517 173 SAGRVQSVALRLICEREMEINRFEIQEYWTIAADFitseKESFKARLISINGEKPD-LKNQASAEAAAALVSKGnYRLKA 251
189347904 173 SAGRVQSVALRLICEREEEINRFEIQEYWTVSADFatakGEIFKAKLVKVDGGKPE-LSSQEQAEAAASLVRNRlYAVGD 251
189501368 173 SAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFttgsGETFSTKLVRIDSNKAE-ITNQSDAEKTASDILSRiYGVAE 251
193213653 173 SAGRVQSVALRLICERENEIEAFEPQEYWTIYADFttesGETFRTKLVKVKGKKPE-IGSGEQAEAIVSAIRDRlFAVSE 251
194335001 173 SAGRVQSVALRLICEREDEIGKFETREYWTLFADFttvsGETFSAKLVKINGKDVD-ITNENDATAVADTILSRiYGVTD 251
194337811 173 SAGRVQSVALRLICEREAEISRFQIQEYWSIAAEFvtagKESFKARLIRFEGDKPE-IANQKQAEALAALIRKGnFAVRE 251
78188059  173 SAGRVQSVALRLICEREEEIERFVIQEYWTIAADFltanKESFRARLVRLDGDKPE-ITNVEQAEAIAAIAKKGnYSVRE 251
19704404  246 SKVSKKTKNPPLPLKTSTLQQLASSYLGFSASKTMMVAQKLYEGISIk-GEHKGLITYMRTDSTRISEEAKEMARNYITK 324
21672896  252 IVPKVIQRKQPLPFTTSLLQQAASNQLGFGSQKTMRTAQQLYEGIDLgsEGATGLITYMRTDSTRISGEAVAQAHDYISQ 331
78187915  252 IAPRTQQRKPPLPFTTSLLQQAASNQLGFGSKKTMRLAQQLYEGIDLgeEGATGLITYMRTDSIRIGNEAAGQARSFIEH 331
145220517 252 IAPRTQQRRAPLPFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIDLgsEGATGLITYMRTDSIRIGDEAKGQARHFIEN 331
189347904 252 ITAKAQQRKAPLPFTTSLLQQAASNQLGFGSQKTMRIAQQLYEGIDLgsEGATGLITYMRTDSTRIGSEAVAEAHKYIRA 331
189501368 252 ITPRVQQRKPPFPFTTSLLQQAASNQLGFGSKKTMRVAQQLYEGIDLgpEGATGLITYMRTDSTRVSGEAVEQAERFITQ 331
193213653 252 IVPKVLQRKQPLPFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIDLgsEGATGLITYMRTDSTRVSGEAIAQAHDYISQ 331
194335001 252 ISSRIQQRKPPVAFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIELgpEGATGLITYMRTDSTRVSAEAVGQAQSYIEQ 331
194337811 252 IAPRVQQRKQPLPFTTSLLQQAASNQLGFGSKKTMGVAQQLYEGIDLgkEGTTGLITYMRTDSTRIGEEAIAEARSYINQ 331
78188059  252 ITPRIQQRKQPLPFTTSLLQQAASNQLGFGAQRTMRTAQQLYEGIELgaEGAMGLITYMRTDSTRISPEAVGEARNYIER 331
19704404  325 NFGKEYLGS--ATPKAKKESKNVQDAHEGIRPTDINYTPENIMEFLDKDQFKLYNLIWQRFLISQLAAMKYEQFEYILEK 402
21672896  332 QFGPEYKGF----GGQGKAGKNAQDAHEAIRPTSVTRTPESLRRHLTPDQFRLYELIWKRFVASMMAPAKIEQTRVDVDD 407
78187915  332 AFGKEYI----GWGGAAKSSKNAQDAHEAVRPTAVGRRPEQLKSYLSADQFKLYDLIWKRFVAAMMAPAKIEQTRVDVGD 407
145220517 332 TFGKEYIG---FGGAAAKSSKNAQDAHEAIRPTSVNRRPEDLKPYLSTDQYRLYDLIWKRFVAAMMAPAKIEQTRVDIAD 408
189347904 332 VFGSEYTGY----GSSAKSPKNAQDAHEAIRPTSIERKPEAMKPYLSADQYRLYELIWKRFLAAMMAPAKIEQTKVDVED 407
189501368 332 HFGPEFTGGgqAA----KKGKKTQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELIWKRFLASRMAPAKIEQTRVDVAD 407
193213653 332 QFGEEYKGF--GGQG--KAGKNAQDAHEAIRPTSVYRTPESLRKHLSADQFKLYELIWKRFVASMMAPAKIEQTRVDVED 407
194335001 332 QFGPQYAGQ----GRAGKNDKKTQDAHEAIRPTSIFRTPAAMKPFLTADQFKLYELIWKRFLASRMAPAKIELTKVEVSD 407
194337811 332 QFGKEYIGFggAA----KPGKNAQDAHEAIRPTSIFNKPDQVKPYLSADQFKLYELIWKRFLASMMSAAKIEQTRVDVED 407
78188059  332 NFGKDYVGAgsSG----KPGKNAQDAHEAIRPTSLLKTPEQVKPYLSADQFKLYELIWKRFLAAMMAPAKIEQTKVDVEE 407
19704404  403 --DK--IEYRGTINKIIFDGYYKVFKEDEDLp----------------IGDFPEIKEGDKFTLDKLDIKEDYTKPPARLT 462
21672896  408 qkKE--FVFRATGNKVLFPGFFRVYDDQQELdyeaqkstreelekeqiVKLPERLSVDEQLKLAELDRRQSFTRPPARYT 485
78187915  408 paRD--IMFRASGSRVLFPGFMRVFNDQEELeyearkstkdegekeqeVRLPKQLEKDGLLGLGEIDNRQSFTRPPARFS 485
145220517 409 peAR--ISFRANGSRVLFPGFMKVFNDQEELayeerkstkdegekeqtVRLPKVLRENDPLNLGPIDSRQSFTRPPARFS 486
189347904 408 --HErrIVFRANGSRVLFPGFMRVYDDQQELeyeartstkedvekeqtVKLPDTLAARDSLNLDEIEQKQSFTRPPARYS 485
189501368 408 heKQ--FIFRASGSNVLFPGFLKVYNEQKELdyearkstredeekeqiVKLPRNLTVNEKLTLDTLDKKQSFTRPPARFT 485
193213653 408 hqKE--FVFRATGNKVLFPGFFKVYNDQQELeyeaqkstrdevekeqmVKLPEKLSVEEQLRMSELDRKQSFTRPPARFT 485
194335001 408 heGE--FLFRANGSKVLFPGFLQVYSDQKELdyeaktstkddeekeqtVQLPKKLDLNEKLDLQTLDKKQSFTRPPARYT 485
194337811 408 saSK--FLFRATGSRVLFPGFMRVYDDQKELdyeaqtstkeevekeltVKLPERLAVNEPLALDDLDQKQSFTRPPARYS 485
78188059  408 qsGK--FLFRANGSRVLFPGFMRVYDDQQELayeaqtstkeevenemvVKLPEKLAVNDPLGLGALEQKQSFTRPPARYS 485
19704404  463 ESSLVKTLEAEGIGRPSTYASIIDTLKKREYVELQNKSFVPTEIGYEVKTQLDKFFPNIMNIKFTAKLEDELDEVDSGDK 542
21672896  486 EASLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGRDVSAILVANFPDLFNVRFTAEMEDELDKVASGDD 565
78187915  486 EATLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTMLGMDVSQILVANFPDLFNVDFTAEMEGELDKVAAGED 565
145220517 487 EATLVKDLDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTVLGMDVSEILVSNFPELFNVDFTAGMENELDKVAVGED 566
189347904 486 EATLVKDLDNYGIGRPSTYASIFSTLQDRRYVVLQKKKIAPTDLGKDVSQILVANFPDIFNIRFTAFMEDELDKVAAGDD 565
189501368 486 EASLVKELDNYGIGRPSTYAGIFSTLQDRRYVELEKKKIIPTELGKDVSMILVANFPDLFNVTFTAHMENELDKIAAGDD 565
193213653 486 EASLVKELDNYGIGRPSTYAAIFSTLQERRYVELQKKKIVPTELGRDVSTILVANFPDLFNVKFTAEMEDELDKVASGDD 565
194335001 486 EASLVKELDNHGIGRPSTYAAIFSTLQDRRYVELLKRKIIPTELGRDVSLILVANFPDLFNVTFTAQMEDELDKVAAGQD 565
194337811 486 EATLVKDLDHFGIGRPSTYASIFSTLQDRRYVELEKKKIVPTELGKDVSLILVANFPDLFNVDFTAFMENELDKVASGED 565
78188059  486 EASLVKDLDHFGIGRPSTYASIFSTLQDRRYVALEKRKIMPTDLGRDVAKILVANFPELFNVGFTAFMEDELDKVASGDD 565
19704404  543 NWIDLLKVFYTELQKYEEKCKVVVEEeleKLVESDVIAKNGkpmimkigrfgrylasqdteskenislkgidisledikk 622
21672896  566 EYEKVLDRFYRPLESVLSHRKSDPLI---PQNRDAVLCEKC--------------------------------------- 603
78187915  566 EYEKVLDSFYRPLETALSVRKEDPLI---PQNRDAALCEKC--------------------------------------- 603
145220517 567 DYESVLDRFYKPLEATLSARKEDPVI---PQNRDAAPCEKC--------------------------------------- 604
189347904 566 EYEKVLDSFYRPLETALSLRKNDPLI---PQNMNAETCDKC--------------------------------------- 603
189501368 566 EYEQVLDSFYKPLESALSVRKNDPLL---PQNTDAETCDKC--------------------------------------- 603
193213653 566 EYEKVLDSFYRPLETVLSHRKSDPLI---PQNREAERCDKC--------------------------------------- 603
194335001 566 DYEKVLDSFYKPLEASLSDRKKDPVL---PQNDKAERCDKC--------------------------------------- 603
194337811 566 EYEKVLDSFYKPLEAVLHLRKSNPIV---PQNSEPVTCEKC--------------------------------------- 603
78188059  566 AYEKVLDSFYKPLTSALALRSATPLI---PQNNEAETCDKC--------------------------------------- 603
19704404  623 gkifvkkqieelgkkkegqktdiildNGSRLLLKYGRFGAYLESENYKEDNIRKTIPKEIKTKIEKNTikkendilylkd 702
21672896  604 --------------------------GKGHMIVKWTTSGKFLGCSNYPKCKNIKAITTNKAKPKETGV------------ 645
78187915  604 --------------------------GEGHMIVKWTQSGKFLGCSRYPKCRNIKPISTNREKPKDTGI------------ 645
145220517 605 --------------------------GEGRMIVKWTQSGKFLGCSRYPKCRNNIPIATNKEKPKDTGI------------ 646
189347904 604 --------------------------GEGRMIIKWTASGKFLGCSRYPACKNIKPISSTKAKPket-------------- 643
189501368 604 --------------------------GKGKMIIKWTASGKFLGCSSYPACKNIKPLASSRVRPKETGI------------ 645
193213653 604 --------------------------GEGHMIVKWTSSGKFLGCSNYPKCKNIKALATNKAKPKETGV------------ 645
194335001 604 --------------------------GTGKMVVKWTSSGKFLGCSEYPKCKNIKPLSNSKPKPKGTGI------------ 645
194337811 604 --------------------------GEGLMVVKWTANGKFFGCSCYPKCKNIKAISNNKAKPVDSAI------------ 645
78188059  604 --------------------------GTGKMILKWTASGKFLGCSNYPKCKNIRTISSNREKPASTGV------------ 645
19704404  703 ifdkiekeeaeilkkagKCEKCGRP-FKISNGRWGKFLACTGYPECKN---------IKKIEKK 756
21672896  646 -----------------RCPVCGEGhMLLRNGRLGPFLACSNYPKCNTllnlskqrhIEPIKTP 692
78187915  646 -----------------LCPSCGEGhMLLRNGRLGPFLACSSYPKCNTllnlskqrhVEPMKIP 692
145220517 647 -----------------LCPSCNEGhMLLRNGRHGAFLACSSYPKCKGllnlgkqrqIEPMKLP 693
189347904 644 ---------------giKCPSCSDGqMLLRDGRLGPFLACSGYPKCNTllnlskqrhIEPLKTP 692
189501368 646 -----------------KCHGCENGrMVLRNGRFGPFLACTGYPDCNTllkldkqrkIEPPKTP 692
193213653 646 -----------------KCPVCGEGhMLLRNGRFGPFLACSNYPKCNTllnlskqrhIEPIKTP 692
194335001 646 -----------------ACPGCEDGhMVLRDGRFGPFLACSNYPKCNTllnldkqrrIQPPKTP 692
194337811 646 -----------------LCPSCKEGhMLLRSGRFGTFLACSGYPKCNTllnlnkqrhIEPMKTP 692
78188059  646 -----------------HCPSCEDGeMVLRKGRLGPFLACSNYPKCNTllnlnkqrhIEPPKTP 692
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