585166 21 LPRPLAEKCPSIIKKFISAydAKPDFVARSPGRVNLIGEHIDYCDFSVLPLAIDFDMLCAVKVLNEKNpsITLINADPKF 100 baker's yeast 12643843 6 ENSTVLSALTEKFAEVFGD--TKEVEYFFSPGRINLIGEHTDYNGGYVFPASITIGTTGLARLREDKK--VKLYSENFPK 81 Lactococcus lactis ... 6225404 1 -----------------------MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTG-----AITARSDR 52 Mycobacterium tuber... 6225404 1 -----------------------MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTG-----AITARSDR 52 Mycobacterium tuber... 18312461 1 ---------------------MEALVKASAPGRLDFLNTHQDYKGLPVVSVAVNMRTRVEMEASKVFE----IESLNTG- 54 Pyrobaculum aerophilum 11132107 1 ---------------------MIKVK---SPGRVNLIGEHTDYTYGYVMPMAINL--YTKIEAEKHGE--VILYSEHFGE 52 Pyrococcus horikoshii 15901681 2 AQHLTTEALRKDFLAVFG---QEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAARKRDDQV--LRFYSANFED 76 Streptococcus pneum... 21759136 15 NPKENKARYAKLLNSFEQKyhCKPDFFSRSPGRVNIIGEHIDYNYFSVLPMAIDVDVIVSVTTSDDAK--VELNNTNPEF 92 fission yeast 6831547 1 ----------------------MKVK---APGRINIIGEHTDYNDGYVLPFAVNR--YVFLSIEGSER--FIFHSENVNE 51 Thermotoga maritima 11132161 6 NTLAMMLRMQRVESCHTEEygDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQTLTLCVSRRKDST--FRLFSLTLGE 83 Treponema pallidum
585166 101 AQRKFDLPLDGSYVTIdpsvSDWSNYFKCglhvaHSFLKKLAPERFAsap--laGLQVFCEGDVPTGSGLSSSAAFICAV 178 baker's yeast 12643843 82 LGVIEFDLDEVEKKDG----ELWSNYVKG-----MIVMLKGAGYEIDk------GFELLIKGEIPTASGLSSSASLELLV 146 Lactococcus lactis ... 6225404 53 ADGSARIPLDTTPGQV----TGWAAYAAG-----AIWALRGAGHPVP-------GGAMSITSDVEIGSGLSSSAALIGAV 116 Mycobacterium tuber... 6225404 53 ADGSARIPLDTTPGQV----TGWAAYAAG-----AIWALRGAGHPVP-------GGAMSITSDVEIGSGLSSSAALIGAV 116 Mycobacterium tuber... 18312461 55 -EKCIFQDPQIAGR-------TFCDYVKA-----AVLALWKHGVYLR-------GFKSVVRSDIPIGAGMASSAALLVSL 114 Pyrobaculum aerophilum 11132107 53 ER--KFSLNDLRKE------NSWIDYVKG-----IFWVLKESDYEVG-------GIKGRVSGNLPLGAGLSSSASFEVGI 112 Pyrococcus horikoshii 15901681 77 KGIIEVPLADLKFEKE----HNWTNYPKG-----VLHFLQEAGHVIDk------GFDFYVYGNIPNGAGLSSSASLELLT 141 Streptococcus pneum... 21759136 93 KEEILELPSDGAVIEInkthHTWGNYFRCsmivaHKYILEKYPELVSggkkplkGLKLIFDGNVPTGGGLSSSAAFCVAS 172 fission yeast 6831547 52 T----VEMEKIEKL------NKWTDYISG-----VIASFEKRGYRVS-------PVKISVSSNLPIGAGLSSSAALEVAT 109 Thermotoga maritima 11132161 84 RRKISTANLRYRKE------DRWANSVKA-----VILSFMDGGYHLT-------GLNCTILSQIPPDAGLGTPNALKVAM 145 Treponema pallidum
585166 179 ALAVVKANmgpGYHMSKQNLMRITVVAE-HYVGVNNGGMDQAASVCGEEDHALYVEFKpQLKATPFKFPQLKnheISFVI 257 baker's yeast 12643843 147 GVVLDDLF---NLNVPRLELVQLGQKTEnDYIGVNSGILDQFAIGFGEVKKAILLDCN-TLKYEMVPVELRD---YDIVI 219 Lactococcus lactis ... 6225404 117 LGAVGAAT---GTRIDRLERARLAQRAEnDYVGAPTGLLDHLAALFGAPKTALLIDFR-DITVRPVAFDPDAc-dVVLLL 191 Mycobacterium tuber... 6225404 117 LGAVGAAT---GTRIDRLERARLAQRAEnDYVGAPTGLLDHLAALFGAPKTALLIDFR-DITVRPVAFDPDAc-dVVLLL 191 Mycobacterium tuber... 18312461 115 IAAALRLA---NREADRATVAELAYVAErEILGVPCGRLDQYGSAFG---KVAVIHPKpPVRVEALEMPGG-----VFVV 183 Pyrobaculum aerophilum 11132107 113 LETLDKLY---NLKLDSLSKVLLAKKAEnEFVGVPCGILDQFAVVFGREGNVIFLDTH-TLDYEYIPFPKD----VSILV 184 Pyrococcus horikoshii 15901681 142 GVVAEHLF---DLKLERLDLVKIGKQTEnNFIGVNSGIMDQFAIGMGADQRAIYLDTN-TLEYDLVPLDLKD---NVVVI 214 Streptococcus pneum... 21759136 173 ILAILKANg-iN-TITKEDLVKISVVSE-HYVGVNTGGMDQCASIYGEQNKALLVQFKpKLMATPFKMPVLKphdMVFLI 249 fission yeast 6831547 110 AYAISEYF---GFNVPKLELVKIAREAEvEFVGVRCGIMDQFTAVFGKKDHAIFLDTM-TLEYEYVPLKLEG---YEINL 182 Thermotoga maritima 11132161 146 ALVLGRLF---AATLPKESVVSIVEHANeRYLKTHAHRADILCVLFAKQGSCVRTDHR-KKQAELCQFPSEG---KRIVL 218 Treponema pallidum
585166 258 ANTLVvsnKFETAPTNYNLRVVEVTTAANVLAAtYgvvllsgkegsstnKGNLRDFMNVYYARYHNISTPwNGdiesgie 337 baker's yeast 12643843 220 MNTNK---PRALTESKYNERFAETREALKRMQT-Rl------------dIQSLGELSNEEFDANTDLIGD--E------- 274 Lactococcus lactis ... 6225404 192 MDSRA---RHCHAGGEYALRRASCERAAADLGV-----------------SSLRAVQDRGLAALGAIA---DP------- 241 Mycobacterium tuber... 6225404 192 MDSRA---RHCHAGGEYALRRASCERAAADLGV-----------------SSLRAVQDRGLAALGAIA---DP------- 241 Mycobacterium tuber... 18312461 184 LDSGV----RHSTAEVHSKRQAELQQAVEMLKAeLgi-----------ySEGYWDFPWGVLYDKPNAVEK-LP------- 240 Pyrobaculum aerophilum 11132107 185 FYTGV---RRELASSEYAERKHIAEESLKILGK-----------------GSSKEVREGELSKLPPLHR----------- 233 Pyrococcus horikoshii 15901681 215 MNTNK---RRELADSKYNERRAECEKAVEELQV-Sl------------dIQTLGELDEWAVDQYSYLIKD--E------- 269 Streptococcus pneum... 21759136 250 SNTLVeanKQETALTNYNLRVVEMAVASEFLAKkFnlelpk---esnlhTGTLRGFMDEYYEKHLKQPHw-DGsdidmgv 325 fission yeast 6831547 183 VDSNV---KHELSSSEYNRRRQECEEVLKTLEK-----------------KSFREVTKEDLERLSGTLR----------- 231 Thermotoga maritima 11132161 219 TDSRV---PRFIAREEFTARLKRCVDAYELVKR----------------NPDMPRAMSKLMAAALEEIDVpEG------- 272 Treponema pallidum
585166 338 rltkmlvlveeslankkqgfsv--ddvaqslncsreeftrdylttspvrfqvlKLYQRAKHVYSESLRVLKAVKLMttas 415 baker's yeast 12643843 275 -----------------------------------------------------TLIKRARHAVYENNRTKIAQKAF---- 297 Lactococcus lactis ... 6225404 242 -----------------------------------------------------IDARRARHVLTENQRVLDFAAAL---- 264 Mycobacterium tuber... 6225404 242 -----------------------------------------------------IDARRARHVLTENQRVLDFAAAL---- 264 Mycobacterium tuber... 18312461 241 -----------------------------------------------------SPLRERVLFTLEMQRSTERALAYlk-r 266 Pyrobaculum aerophilum 11132107 234 --------------------------------------------------------KFFGYIVRENARVLEVRDAL---- 253 Pyrococcus horikoshii 15901681 270 -----------------------------------------------------NRLKRARHAVLENQRTLKAQVAL---- 292 Streptococcus pneum... 21759136 326 qrmqemlrlteimfseeqkvgfkteelakelglsveeftkvfltkipvkyermKIYQRTVHVYSDAMRVLQVLKLFhqhk 405 fission yeast 6831547 232 --------------------------------------------------------KRAQHVLEENERVLKSVQAL---- 251 Thermotoga maritima 11132161 273 ------------------------------------------------------IRRRVISLVRESLGVDEAIEAL---- 294 Treponema pallidum
585166 416 FTADed-fFKQFGALMNESQASCDKLYECSCPEIDKICSIALSNGS------YGSRLTGAGWGGCTVHLVpggPNGNIEK 488 baker's yeast 12643843 298 VAGN----LTKFGELLNASHASLKDDYEVTGLELDTLAETAQKQAGv-----LGARMTGAGFGGCAIALV---AHDNVSA 365 Lactococcus lactis ... 6225404 265 ADSD----FTAAGQLLTASHESMREDFAITTERIDLIAESA-VRAGa-----LGARMTGGGFGGAVIALV---PADRARD 331 Mycobacterium tuber... 6225404 265 ADSD----FTAAGQLLTASHESMREDFAITTERIDLIAESA-VRAGa-----LGARMTGGGFGGAVIALV---PADRARD 331 Mycobacterium tuber... 18312461 267 RDLPteeiLRKVGAEMLLQHRLLSELYDVSLPELDRLVEEAVNAGA------YGAKLSGAGLGGVVIALA---PNR---E 334 Pyrobaculum aerophilum 11132107 254 KEGN----VEEVGKILTTAHWDLAKNYEVSCKELDFFVERAL-KLGa-----YGARLTGAGFGGSAIALV---DKEDAET 320 Pyrococcus horikoshii 15901681 293 QAGD----LETFGRLMNASHVSLEHDYEVTGLELDTLVHTAWAQEGv-----LGARMTGAGFGGCAIALV---QKDTVEA 360 Streptococcus pneum... 21759136 406 DSDDpqkfMLAFGRLLNDSQRSEDIYNNSSSPELREVCKISLANGG------YGARTTGAGWGGSAVHLT---THDKLAK 476 fission yeast 6831547 252 KEGD----FETLGKLLFSSHESLRDLYEVSCEETDFIVDYLRGKEGi-----LGARMVGGGFGGGVIVLS---KKGAFGK 319 Thermotoga maritima 11132161 295 RKRD----FAAFSRVVNRSHERLRDRFEISCPELDWLVKRALEFVDpdapdvVCSRLTGRGFGGCTYAIL---RDQDFEP 367 Treponema pallidum
585166 489 VKEALANEFYKVKYpkitdaeLENAIIVSKPALGSCLYE 527 baker's yeast 12643843 366 FEKAVGQVYEEVVG-------YPASFYVAQIGSGSTKLD 397 Lactococcus lactis subsp. lactis 6225404 332 VADTVR-RAAVTAGy------DEPAVSRTYAAPGAAECR 363 Mycobacterium tuberculosis 6225404 332 VADTVR-RAAVTAGy------DEPAVSRTYAAPGAAECR 363 Mycobacterium tuberculosis 18312461 335 TAEKIGRRSSAVKW------------WAVEVDEGLKYGD 361 Pyrobaculum aerophilum 11132107 321 IGEEILREYLKRFP-------WKARHFIVEPSDGVG-I- 350 Pyrococcus horikoshii 15901681 361 FKEAVGKHYEEVVG-------YAPSFYIAEVAGGTRVLD 392 Streptococcus pneumoniae TIGR4 21759136 477 LVEALTEQYYKKQFpkitqseLNAAVVVSKPAAGSCIVQ 515 fission yeast 6831547 320 IKEELVESYRKRFG-------IDLIFHEIESSDGVQKI- 350 Thermotoga maritima 11132161 368 YLERLD-EYERIFG-------FKAAAYEVQCSEGARVL- 397 Treponema pallidum
Jiyao W et al.(2023). "The conserved domain database in 2023.",