3PQD,1A5Z


Conserved Protein Domain Family
Mdh

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COG0039: Mdh 
Malate/lactate dehydrogenase [Energy production and conversion]
Malate/lactate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Statistics
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PSSM-Id: 439809
Aligned: 806 rows
Threshold Bit Score: 164.42
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PQD_A         6 NKVALI-GA-GFVGSSYAFALINQG---ITDELVVIDV--NKE--KAMGDVMDLNHGKAFAP-------------QPVKT 63 
WP_012537534   1 MDVSII-GAnGSTGKHIASRILLERlllPTDRLQLVGRrdGSSgnALYGFRQDLKDAFAEHC-------------PIIDI 66 
WP_013581449   3 LSIAIV-GAgGAVGSALLMHLLKSStlqAGDEVVLLGRgtPESsgRLFAIRMDLLDAFDESA-------------IRISV 68 
WP_008415577   1 MDVVVIgGG-GTVGSTVAYTLSVQI---PATNVTLVDT--DID--AAEGHAIDIRHSMCHATyglgrpdfaseplGSVHV 72 
WP_049954884   1 mHTVIIgGA-STIGVTIAYTLATVE---PTMDLTLLDK--DRK--SAWAHGLDIAHSTFHSTqspvdq-etadsfGAIQA 71 
WP_049954977   1 mHVAIIgGA-STIGSTVAYTLATKD---PTMDISLVDK--APE--PAWAHAMDITHSKYHGTdapvde-rtaasyGTVTG 71 
WP_070078047   1 MNIAVI-GAtGLTGHQVVVQLILKGlvgPMDRVQLVGRppAEA--RLRGMVADIRDAFFEAA-------------PELDI 64 
WP_088428994   1 MDVSVI-GAsGDCGREIVSQLVALGalaPTERLQLVGRpqGRSarVLYGLCSDLNDAYAEMA-------------PMLDV 66 
WP_110136169   1 MDIAII-GAnGSIGRQIAVRIIMERllgPTDRLQFVGRsdGRSavALYGFRQDLKDAFSENC-------------PLLDV 66 
WP_087470485   1 MDVAVV-GAtGDVGRQVCTQIVERRvlpPTARLQLVGRagGASgrAVHGLRADLVDAYDEHA-------------PLLDV 66 
3PQD_A        64 S-YgtyEDCKDADIVCICAGANQ-KP-G-------E----TRLELVEKNLKIFKGIVSEVMASGF-DGIFLVATNPVDIL 128
WP_012537534  67 AlQ---PEEVVADIIVMAAGKTI-QA-HsdpgkapP----SRDELAIYNQQIAIPYADALVQYGHgHEVVIVVTNPVELI 137
WP_013581449  69 CeS---IGDLKADVVIIAAGYTI-SP-Sr------R----TRRDLAASNQPLFQSLAAKLSR-TVpNALFLIVSNPVELA 132
WP_008415577  73 A-EpspSVVSESDCLVVTASAPRpKD-Gda--------rgGRLTFLERNLEIVDNIAAWLNEADP--TPVIVVSNPVDRI 140
WP_049954884  72 V-GsdgLDDLDPDLIVFTAAAPQ--PaD-------AtsadARDAELEANRSIVDSVAPALRSNRP--VPVLVLSNPIDRI 139
WP_049954977  72 V-GtdeMSSIDPDLVVLTAAAPR--PdD-------AadrgVRKAELEANRAIADDVATQLQSIDP--VPVVVLTNPIDRI 139
WP_070078047  65 TlS---PEEIAAEVIVFAAGVTL-PT-Dsr---tpM----TRDALAIANRTLFETYAQAIARHGHgHELVIVVSNPVELG 132
WP_088428994  67 AlA---PEAIVADVIVMAAGATV-AG-Ei------T----SRADLAAVNLPLFETYAQAIARYGGgHEIVIIVTNPVELA 131
WP_110136169  67 AlE---PEDVVADIVIMAAGETI-HS-DqdrtaamP----SRDDLAIANRALAIRYADALCRYGHgHEIVVVVTNPVELL 137
WP_087470485  67 AhS---PDDVTADVIVVAAGLTP-PA-Rtg---adP----DRRALAATNGAVLAEYADAIARHGSgHEVVIVVTNPVELG 134
3PQD_A       129 TYATWKfsGLPKERVIGSGTTLDSARFRFMLSEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEknd---- 204
WP_012537534 138 VEIFSQ--RYDRHRIVGMGAYQDSLRFRREVARSINVSREAVRAMVLGEHGDGIVPLWSSVTIQGFSDNETARaisnvrs 215
WP_013581449 133 VGIFAA--HMEPQRVIGIGAQQDSLRFARAIASQIGVHRSKVRASVLGEHGQAMVPLWSSVHLT-LDEPETASrlaalie 209
WP_008415577 141 THRLWRqtGWPRQRFLGYS-LSETARIADEIARQTDASPREVYCPILGEHGEHIVPIFSRATVSGEPVNf---------- 209
WP_049954884 140 TYRLWKqvGWSRKYFLGYS-VSETARVAHRISEIQDVHPGTVYCPVMGEHGSEIVPIFSRLRIDGVATTl---------- 208
WP_049954977 140 TYRLWTqlGWPREKFIGYS-LSETARTAHAIADLQGVHPSRVSCPVMGEHGEGIVPIFSRARVGEASVSl---------- 208
WP_070078047 133 VSIFAH--HLGRRRVFGMGAYQDTLRFRREIAGELGLARQRVEAYMLGEHGSGLVPTWSSLRLHGFDPEETDQlrrrlrr 210
WP_088428994 132 VEVFSR--QLGRHRVIGVGAYSDSLRFRREIAADLGVRRQLVQGFIVGEHGEGMVPLWSSVQVHGMTLEEVRDarrrlqr 209
WP_110136169 138 VDIFSA--RYDRKRVIGIGAYQDSLRFRREVARSINVSRQAVRAMAIGEHGDGLVPLWSSVIVQGFSDSETRRaihavrg 215
WP_087470485 135 VAVMAE--RLGRHRVLGMGAWLDTLRFRRELAVELGVRRHRVGGFVGGQHGEDAVPLWSTVRVSGLDADERARavaalrr 212
3PQD_A       205 -----ayKQE-E--LDQIVDDVKN----AAYHIIE-----------------KK-GATYYGVAMSLARITKAILHNE-NS 253
WP_012537534 216 stssrefPGTlIrmRNEIIKIAQRgdiaEAFRRFDtlppdvrimvgpfltlfAG-AKTDIATANATVDLFKCMLSGK-DT 293
WP_013581449 210 rfensdtRSEvNrtRDTLESLLADhqlaAAYEVMEhvspstrimlepfithsQI-HSTPNATANATLEILGAALMAD-GR 287
WP_008415577 210 -------SES-E--RDDIVEYVRD----VPYDVLKl---------------rGAqDSSRWVTARGVASVVQRLDDDCaDA 260
WP_049954884 209 -------TDE-Q--RSDVRRYARE----IPFEIAKe---------------rGVsETSRWVTSAGVVRIIRKMMAND-PS 258
WP_049954977 209 -------TPE-Q--ESEVLEYVRD----VPFEIASk---------------rGAgETSRWVTSAGVAKVVRSMLSGEtTS 259
WP_070078047 211 gltsagyPDTlAneTKGIRALIEAgdlgEAFRHIGtlpadlrvglgpfathySG-AKTAVATANATVDMLRVVLSGH-QT 288
WP_088428994 210 drivsdfPKEvSqeKQAVLAYLKAgdipQAYRYVDslppdlrvvvkpfvthiSG-AKTITATANVTVDLVQNLLQGR-EI 287
WP_110136169 216 grvstdyPDSvDaaRTQIIQIAREgrirEAFALFDtlapdvrvvigpfltlfSG-AKTDVATANATVDLVCTIVGGR-DS 293
WP_087470485 213 grtldalPAEiAaaKTELARVAAEdm-gAAFDLIDawpadlrlvarpwmthqSG-AKTPAGTASATVDLLEVILDGR-EI 289
3PQD_A       254 ILTVSTYLDGQY-GA-D-----------DVYIGVPAVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILK 311
WP_012537534 294 VIAAQVSLVNEFlQV-------------RGPIGAPVVISPKGWDAVYPMTLSDGEQQLFLQSAQSIQEKVN 351
WP_013581449 288 RVHGQVQLHGQFqGI-------------KGVCGVPLEVRLTGWQVSSQLRLTASEIADLHAAAEAIEVAIQ 345
WP_008415577 261 LVCLSTPLEGEY-GF-K-----------DVSLSVPVRLDKDGVANIVEWSLVEEERTALEDAYRVVRTST- 317
WP_049954884 259 PTCLSTPLAGEY-GF-S-----------DGCLSVPVVLTLDGVTDIIEWDLSADEKQRLKSAHETICTDIE 316
WP_049954977 260 PGCLSTPLSGEY-GF-D-----------DGCLSVPVSVDSTGVTAIHEWELADTEYERLVDAFESVRTDLE 317
WP_070078047 289 VMAAQVALKGEWlGL-------------DTVIGVPVLVGHQGWVTVNPLPLDDDEHAQLCAVGRGVTDKLR 346
WP_088428994 288 VVSGQVQLDGEFyGV-------------RTPFGVPIVVTPFGWTQVVPLELWAEEADLLHRMANQLSHRLQ 345
WP_110136169 294 VVAAQVQLRGEFeGV-------------HTSIGVPIIVNTKGWESAYPLAMTDGERQLFLSAAARVQEKIK 351
WP_087470485 290 VVAGQVALDGELdGRlDgmpsgpdgspyRGVLGVPVVLGPGGWTRVLLDELPDDEARRLAHAADGVGRMVA 360
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